| WBGene00000798 | Evidence | Paper_evidence | WBPaper00005857 |
|---|
| SMap | S_parent | Sequence | C14A4 |
| Identity | Version | 2 |
| | Name | CGC_name | crn-5 | Person_evidence | WBPerson1606 |
| | | Sequence_name | C14A4.5 |
| | | Molecular_name | C14A4.5 |
| | | | C14A4.5.1 |
| | | | CE02146 |
| | | Other_name | exos-5 | Person_evidence | WBPerson699 |
| | | | | | WBPerson6229 |
| | | | CELE_C14A4.5 | Accession_evidence | NDB | BX284602 |
| | | Public_name | crn-5 |
| | DB_info | Database | AceView | gene | 2K883 |
| | | | WormQTL | gene | WBGene00000798 |
| | | | WormFlux | gene | WBGene00000798 |
| | | | NDB | locus_tag | CELE_C14A4.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000798|UniProtKB=G5EG59 |
| | | | | family | PTHR11953 |
| | | | NCBI | gene | 174634 |
| | | | RefSeq | protein | NM_063883.4 |
| | | | SwissProt | UniProtAcc | G5EG59 |
| | | | TREEFAM | TREEFAM_ID | TF315920 |
| | | | UniProt_GCRP | UniProtAcc | G5EG59 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 04 Jun 2007 15:54:19 | WBPerson2970 | Name_change | Other_name | exos-5 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | crn |
| | Allele (16) |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Contained_in_operon | CEOP2496 |
| | Ortholog (34) |
| | Paralog | WBGene00000202 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00007201 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | crn-5 encodes a cell death-related nuclease which is a homolog of Rrp46, an eukaryotic ribonulease component of the exosome, involved in RNA processing; crn-5 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-1, crn-4, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-5 has been shown to bind DNA without detectable DNase activity but enhances the DNase activity of CRN-4, a DEDD family apoptotic DNAase and RNase. | Paper_evidence | WBPaper00005857 |
| | | | | | WBPaper00036712 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 Oct 2010 00:00:00 |
| | | Automated_description | Enables double-stranded DNA binding activity and enzyme binding activity. Involved in RNA processing and apoptotic DNA fragmentation. Part of exosome (RNase complex). Is an ortholog of human EXOSC5 (exosome component 5). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C14A4.5 |
| | Corresponding_transcript | C14A4.5.1 |
| | Other_sequence | Hbac_isotig03698 |
| | | CJC05327_1 |
| | | CGC00890_1 |
| | | CBC01241_1 |
| | | EX010442.1 |
| | Associated_feature | WBsf989405 |
| | | WBsf222035 |
| Experimental_info | RNAi_result (9) |
| | Expr_pattern | Expr1018453 |
| | | Expr1030497 |
| | | Expr1144540 |
| | | Expr2010540 |
| | | Expr2028780 |
| | Drives_construct | WBCnstr00037268 |
| | Construct_product | WBCnstr00037268 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040560:hpl-2_embryo_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00053810:sod-2(ok1030)_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:C28H8.4-ZK418.5_10918 |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(186_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MDE |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_ME |
| | Interaction (40) |
| | WBProcess | WBbiopr:00000014 |
| | | WBbiopr:00000103 |
| Map_info | Map | II | Position | 3.12021 | Error | 0.000298 |
| | Positive | Positive_clone | C14A4 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00005857 |
| | WBPaper00006283 |
| | WBPaper00019408 |
| | WBPaper00027291 |
| | WBPaper00029254 |
| | WBPaper00029257 |
| | WBPaper00036712 |
| | WBPaper00038491 |
| | WBPaper00055090 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
