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WormBase Tree Display for Gene: WBGene00000218

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Name Class

WBGene00000218EvidenceCGC_data_submission
SMapS_parentSequenceF21F8
IdentityVersion1
Name (5)
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classasp
Allele (19)
StrainWBStrain00055495
RNASeq_FPKM (74)
GO_annotation00024940
00024941
00024942
00024943
00024944
00024945
00024946
00107044
00107045
Contained_in_operonCEOP5539
Ortholog (45)
Paralog (17)
Structured_descriptionAutomated_descriptionPredicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human REN (renin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (17)
Molecular_infoCorresponding_CDSF21F8.3
Corresponding_transcriptF21F8.3.1
Other_sequence (84)
Associated_featureWBsf646998
WBsf232089
Experimental_infoRNAi_resultWBRNAi00022726Inferred_automaticallyRNAi_primary
WBRNAi00022727Inferred_automaticallyRNAi_primary
WBRNAi00076324Inferred_automaticallyRNAi_primary
WBRNAi00115179Inferred_automaticallyRNAi_primary
WBRNAi00013692Inferred_automaticallyRNAi_primary
WBRNAi00022728Inferred_automaticallyRNAi_primary
WBRNAi00045228Inferred_automaticallyRNAi_primary
WBRNAi00078339Inferred_automaticallyRNAi_primary
WBRNAi00089049Inferred_automaticallyRNAi_primary
WBRNAi00045227Inferred_automaticallyRNAi_primary
Expr_patternChronogram794
Chronogram1262
Expr4352
Expr5817
Expr1017234
Expr1030135
Expr1149160
Expr2009469
Expr2027707
Drives_constructWBCnstr00003435
WBCnstr00037654
Construct_productWBCnstr00037654
Microarray_results (22)
Expression_clusterWBPaper00028802:intestine_unique
WBPaper00029359_1174
WBPaper00029359_1280
WBPaper00029359_1289
WBPaper00029359_1304
WBPaper00029359_1312
WBPaper00029359_1330
WBPaper00029359_1444
WBPaper00029359_1497
WBPaper00029359_1504
WBPaper00029359_1553
WBPaper00029359_1604
WBPaper00032528:L3_enriched
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_embryo_enriched
WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00042194:nhr-114(RNAi)_downregulated
WBPaper00044128:daf-2(e1370)_downregulated
WBPaper00044128:DietaryRestriction_downregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045217:prg-1_progressively_regulated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048644:germline_enriched
WBPaper00048785:heat-shock_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048952:glucose_repressed
WBPaper00048988:daf-2(e1370)_upregulated_neuron
WBPaper00048988:daf-16(mu86)_downregulated_neuron
WBPaper00048988:neuron_expressed
WBPaper00049177:rpn-10(ok1865)_downregulated
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049484:elt-2(RNAi)_downregulated_L1
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050121:mir-60(n4947)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:ash-2(RNAi)_regulated_intestine
WBPaper00051039:intestine_enriched
WBPaper00051305:vit-2(ac3)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053254:hsp-90(RNAi)_downregulated_protein
WBPaper00053302:stavudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053599:female_vs_male_downregulated
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:OP50_vs_PY79_downregulated_PY79
WBPaper00054758:alg-1(gk204)_downregulated
WBPaper00054872:egl-9(sa307)_upregulated
WBPaper00054996:activated_sperm_CE
WBPaper00055049:S.gordonii_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055969:electromagnetic-field_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056139:gut-microbiota_upregulated
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
WBPaper00056826:hmc_biased
WBPaper00056900:PID-3_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057265:metaformin_upregulated_OP50
WBPaper00057288:iff-1(RNAi)_upregulated_protein
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058665:graphene-oxide_upregulated_mRNA
WBPaper00058948:PA14_downregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
WBPaper00059421:daf-1(m40)_upregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_downregulated
WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060683:hlh-11(overexpression)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-infection_24h_regulated
WBPaper00060908:TEBP-1_interacting
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:F54D5.3_7003-F54D5.3_7004
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062590:Aging_upregulated_neuron
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064005:starvation_upregulated_N2_protein
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064403:Heat-killed-E.Coli_upregulated
WBPaper00064473:ets-4(rrr16)_downregulated
WBPaper00064602:egl-9(sa307)_upregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:AFD_depleted
WBPaper00065258:anchor-cell_depleted
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065392:Lb.rhamnosus_upregulated
WBPaper00065581:hpk-1(pk1393)_downregulated
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_0
WBPaper00065841:3_1
WBPaper00065841:3_2
WBPaper00065841:3_4
WBPaper00065841:3_5
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066085:hda-3(ok1991)_upregulated
WBPaper00066085:sin-3(tm1276)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_1_3
cgc4489_group_25
WBPaper00005124:progesterone_10-7M_regulated
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030985:Enterococcus_faecalis_upregulated
WBPaper00030985:Erwinia_carotovora_upregulated
WBPaper00030985:Photorhabdus_luminescens_upregulated
WBPaper00031003:hlh_1_enriched
WBPaper00032062:age_regulated_genes
WBPaper00032165:differentially_expressed_with_age_medoid_4
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-10_regulated
WBPaper00035892:Y.pestis_regulated
WBPaper00036286:Pattern_I
WBPaper00036383:ash-2_Day8_regulated
WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
WBPaper00037113:Diazinon_16C_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_24h
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00048989:N2_allantoin_downregulated
Interaction (91)
Map_infoMapVPosition1.26261Error0.001344
PositivePositive_cloneF21F8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (11)
RemarkSequence connection from [Freedman J]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene