WormBase Tree Display for Gene: WBGene00000584

WBGene00000584 Evidence: Paper_evidence: WBPaper00005610
  SMap: S_parent: Sequence: R03C1
  Identity: Version: 1
    Name: CGC_name: cog-1 Person_evidence: WBPerson625
      Sequence_name: R03C1.3
      Molecular_name: R03C1.3a
        R03C1.3a.1
        CE25964
        R03C1.3b
        CE33290
        R03C1.3b.1
      Other_name: CELE_R03C1.3 Accession_evidence: NDB BX284602
      Public_name: cog-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cog
    Allele (136)
    Legacy_information: cog for Connection of Gonad defective, adults are Egl with abnormal vulval morphology and abnormal connection between uterus and vulva, males are sperm transfer defective with abnormal connection between the vas deferens and the proctodeum
    Strain (15)
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (41)
    Paralog: WBGene00000428 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000434 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000445 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000447 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000449 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000450 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: cog-1 encodes the C. elegans ortholog of the vertebrate Nkx6 homeodomain proteins; cog-1 activity is required for multiple aspects of reproductive system development, including connection of uterus to the vulva and vulval cell specification, as well as for specification of left/right asymmetry in the ASE taste receptor sensory neurons where cog-1 acts in ASER to suppress the ASEL cell fate; cog-1 expression in ASEL is negatively regulated by the lsy-6 miRNA; a cog-1::gfp reporter fusion is expressed in neurons and in the hermaphrodite vulva and uterus; in males, cog-1::gfp expression is seen in proctodeal cells and occasionally in the rectal Rep cells and P11.pp progeny. Paper_evidence: WBPaper00005610
            WBPaper00006052
            WBPaper00006260
            WBPaper00031556
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Feb 2009 00:00:00
      Automated_description: Enables DNA-binding transcription factor binding activity. Involved in several processes, including determination of left/right symmetry; neuron development involved in amphid sensory organ development; and regulation of gene expression. Predicted to be located in nucleus. Expressed in several structures, including body ganglion; egg-laying apparatus; head neurons; male-specific anatomical entity; and tail ganglion. Human ortholog(s) of this gene implicated in spastic ataxia 8. Is an ortholog of human NKX6-1 (NK6 homeobox 1) and NKX6-2 (NK6 homeobox 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080252 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19321)
  Molecular_info: Corresponding_CDS: R03C1.3a
      R03C1.3b
    Corresponding_transcript: R03C1.3a.1
      R03C1.3b.1
    Other_sequence (13)
    Associated_feature (16)
    Transcription_factor: WBTranscriptionFactor000687
  Experimental_info: RNAi_result: WBRNAi00107689 Inferred_automatically: RNAi_primary
      WBRNAi00001218 Inferred_automatically: RNAi_primary
      WBRNAi00051169 Inferred_automatically: RNAi_primary
      WBRNAi00017345 Inferred_automatically: RNAi_primary
      WBRNAi00062927 Inferred_automatically: RNAi_primary
      WBRNAi00034550 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00004665
      WBCnstr00004666
      WBCnstr00004672
      WBCnstr00006876
      WBCnstr00006877
      WBCnstr00014600
      WBCnstr00017428
      WBCnstr00023015
      WBCnstr00037445
      WBCnstr00042865
    Construct_product: WBCnstr00006104
      WBCnstr00006105
      WBCnstr00007700
      WBCnstr00016151
      WBCnstr00017428
      WBCnstr00021774
      WBCnstr00037445
    Microarray_results (30)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00041071:spe-44_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00046121:mesoderm_unique
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:hermaphrodite-Z1-Z4_enriched
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055648:vulva-uterus_expressed
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADF
      WBPaper00061340:ALM_BDU
      WBPaper00061340:ALN
      WBPaper00061340:ASG
      WBPaper00061340:ASH
      WBPaper00061340:B
      WBPaper00061340:B_F_K_Kp_U_Y
      WBPaper00061340:F_U
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:K_Kprime
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:Neuroblast_ASH_RIB
      WBPaper00061340:Parents_of_U_F_B_DVA
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:PLM
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:Y
      WBPaper00061340:Z1_Z4
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:daf-1_17383-epc-1_15051
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061651:PDA_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00062103:neuron_enriched
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065841:11_0
      WBPaper00065841:11_2
      WBPaper00065841:29_0
      WBPaper00065841:68_1
      WBPaper00065841:102_0
      WBPaper00065841:104_0
      WBPaper00065841:111_0
      WBPaper00065841:130_0
      WBPaper00065841:134_0
      WBPaper00065841:136_0
      WBPaper00065841:146_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_8
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026952:class_E
      WBPaper00032062:age_regulated_genes
      WBPaper00042274:tbx-2(bx59)_downregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_C
    Interaction (143)
  Map_info: Map: II Position: 23.6958 Error: 0.059369
    Well_ordered
    Positive: Positive_clone: R03C1 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: R13D4
    Mapping_data: Multi_point: 3511
        3512
        4085
        4193
        5524
      Pos_neg_data: 9070
        9071
        9072
        9073
        9074
        9075
  Reference: WBPaper00003878
    WBPaper00005610
    WBPaper00005987
    WBPaper00006052
    WBPaper00006260
    WBPaper00006364
    WBPaper00006373
    WBPaper00006457
    WBPaper00016800
    WBPaper00017759
    WBPaper00019277
    WBPaper00022900
    WBPaper00023640
    WBPaper00024291
    WBPaper00024433
    WBPaper00024529
    WBPaper00025135
    WBPaper00025365
    WBPaper00025366
    WBPaper00025663
    WBPaper00025930
    WBPaper00026718
    WBPaper00026788
    WBPaper00027031
    WBPaper00027237
    WBPaper00027282
    WBPaper00027299
    WBPaper00027309
    WBPaper00027316
    WBPaper00027410
    WBPaper00027840
    WBPaper00028195
    WBPaper00028375
    WBPaper00028430
    WBPaper00029327
    WBPaper00029406
    WBPaper00030289
    WBPaper00030530
    WBPaper00030702
    WBPaper00030829
    WBPaper00030973
    WBPaper00031349
    WBPaper00031864
    WBPaper00032452
    WBPaper00032489
    WBPaper00032877
    WBPaper00032974
    WBPaper00034023
    WBPaper00034710
    WBPaper00035106
    WBPaper00035599
    WBPaper00036657
    WBPaper00038491
    WBPaper00038897
    WBPaper00039757
    WBPaper00040144
    WBPaper00042343
    WBPaper00043849
    WBPaper00043989
    WBPaper00044621
    WBPaper00045967
    WBPaper00047247
    WBPaper00048898
    WBPaper00055090
    WBPaper00060123
    WBPaper00061738
    WBPaper00064415
  Method: Gene