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WormBase Tree Display for Gene: WBGene00000182

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Name Class

WBGene00000182SMapS_parentSequenceB0336
IdentityVersion3
NameCGC_namearf-1
Sequence_nameB0336.2
Molecular_nameB0336.2
B0336.2.1
CE00696
B0336.2.2
Other_nameARF/1
arf-1.2
CELE_B0336.2Accession_evidenceNDBBX284603
Public_namearf-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
205 Nov 2004 15:32:14WBPerson2970Name_changeCGC_namearf-1.2
310 Sep 2020 13:24:17WBPerson1983Name_changeCGC_namearf-1
Other_namearf-1.2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classarf
Allele (33)
Legacy_information[C.elegansII] NMK. Encodes 181 aa predicted class I ARF. [CGC, MQ]
RNASeq_FPKM (74)
GO_annotation (22)
Contained_in_operonCEOP3332
Ortholog (45)
Paralog (14)
Structured_descriptionConcise_descriptionarf-1.2 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase.Paper_evidenceWBPaper00012958
WBPaper00013160
WBPaper00015195
Curator_confirmedWBPerson567
Date_last_updated16 Jul 2007 00:00:00
Automated_descriptionPredicted to enable GTP binding activity and GTPase activity. Involved in several processes, including oocyte development; regulation of apoptotic process involved in development; and regulation of receptor-mediated endocytosis. Located in endoplasmic reticulum. Expressed in pharyngeal muscle cell; uterus; ventral nerve cord; and vulval precursor cell. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARF1 (ADP ribosylation factor 1) and ARF3 (ADP ribosylation factor 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050454Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:652)
Molecular_infoCorresponding_CDSB0336.2
Corresponding_transcriptB0336.2.1
B0336.2.2
Other_sequence (178)
Associated_feature (13)
Experimental_infoRNAi_resultWBRNAi00079565Inferred_automaticallyRNAi_primary
WBRNAi00090606Inferred_automaticallyRNAi_primary
WBRNAi00080007Inferred_automaticallyRNAi_primary
WBRNAi00079703Inferred_automaticallyRNAi_primary
WBRNAi00109355Inferred_automaticallyRNAi_primary
WBRNAi00002442Inferred_automaticallyRNAi_primary
WBRNAi00079795Inferred_automaticallyRNAi_primary
WBRNAi00079657Inferred_automaticallyRNAi_primary
WBRNAi00098332Inferred_automaticallyRNAi_primary
WBRNAi00062565Inferred_automaticallyRNAi_primary
WBRNAi00079611Inferred_automaticallyRNAi_primary
WBRNAi00080008Inferred_automaticallyRNAi_primary
WBRNAi00109452Inferred_automaticallyRNAi_primary
WBRNAi00085364Inferred_automaticallyRNAi_primary
WBRNAi00062560Inferred_automaticallyRNAi_primary
WBRNAi00087059Inferred_automaticallyRNAi_primary
WBRNAi00098428Inferred_automaticallyRNAi_primary
WBRNAi00001184Inferred_automaticallyRNAi_primary
WBRNAi00109549Inferred_automaticallyRNAi_primary
WBRNAi00079978Inferred_automaticallyRNAi_primary
WBRNAi00087057Inferred_automaticallyRNAi_primary
WBRNAi00079749Inferred_automaticallyRNAi_primary
WBRNAi00028094Inferred_automaticallyRNAi_primary
WBRNAi00038944Inferred_automaticallyRNAi_primary
WBRNAi00002820Inferred_automaticallyRNAi_primary
WBRNAi00083356Inferred_automaticallyRNAi_primary
WBRNAi00080493Inferred_automaticallyRNAi_primary
WBRNAi00115381Inferred_automaticallyRNAi_primary
WBRNAi00008295Inferred_automaticallyRNAi_primary
WBRNAi00087061Inferred_automaticallyRNAi_primary
WBRNAi00109258Inferred_automaticallyRNAi_primary
WBRNAi00109160Inferred_automaticallyRNAi_primary
WBRNAi00079519Inferred_automaticallyRNAi_primary
WBRNAi00079473Inferred_automaticallyRNAi_primary
WBRNAi00087060Inferred_automaticallyRNAi_primary
WBRNAi00024381Inferred_automaticallyRNAi_primary
WBRNAi00087207Inferred_automaticallyRNAi_primary
WBRNAi00087058Inferred_automaticallyRNAi_primary
Expr_patternChronogram1686
Expr3149
Expr4834
Expr5055
Expr15679
Expr1028066
Expr1030106
Expr1143124
Expr2009391
Expr2027627
Drives_constructWBCnstr00002999
WBCnstr00011177
WBCnstr00012265
WBCnstr00019869
WBCnstr00037680
WBCnstr00042476
Construct_productWBCnstr00008785
WBCnstr00008786
WBCnstr00019869
WBCnstr00037680
WBCnstr00042476
Microarray_results (26)
Expression_clusterWBPaper00029359_1197
WBPaper00029359_1208
WBPaper00029359_1225
WBPaper00029359_1242
WBPaper00029359_1291
WBPaper00029359_1367
WBPaper00029359_1483
WBPaper00029359_1494
WBPaper00029359_1546
WBPaper00029359_1561
WBPaper00029359_1692
WBPaper00032528:L3_enriched
WBPaper00033070:Elbe_upregulated
WBPaper00037946:MAB-5_interacting
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038118:stress_upregulated_N2
WBPaper00038289:oocyte_protein
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00040221:DAF-12_target_ALF4
WBPaper00041072:UTX-1_interacting_protein
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050599:nicotine(0.01mM)_upregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053599:female_vs_male_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00055049:S.gordonii_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
WBPaper00059471:EGL-43_interacting
WBPaper00059605:MUT-16_interacting
WBPaper00059763:neuron_expressed
WBPaper00060084:cco-1(RNAi)_downregulated_N2
WBPaper00060661:sensory-neuron_enriched
WBPaper00061340:XXX
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:arf-1.2_3224-trap-2_2175
WBPaper00061527:tars-1-AFFX-r2-3026-5_at
WBPaper00061651:Spermatheca_enriched
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064130:Beta-Amyloid_upregulated_protein
WBPaper00064163:ZNFX-1_interacting_embryo
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_downregulated_WT
cgc4386_cluster_6_3
cgc4489_group_8
WBPaper00025032:cluster_22
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031832:slr-2_regulated
WBPaper00032165:A_to_C_transit_increased
WBPaper00032948:FedUp
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_G
WBPaper00036383:ash-2_Day8_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-exposed_24h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00048989:N2_allantoin_downregulated
WBPaper00048989:N2_rapamycin_upregulated
[cgc5767]:cluster_27
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
Interaction (182)
Map_infoMapIIIPosition-1.44726Error0.000356
PositivePositive_cloneB0336Inferred_automaticallyFrom sequence, transcript, pseudogene data
NM#G4
Mapping_dataMulti_point4788
5049
Pseudo_map_position
Reference (37)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
This gene was previously assigned the CGC name arf-1. It has been re-assigned to arf-1.2Curator_confirmedWBPerson2970
MethodGene