WormBase Tree Display for Gene: WBGene00019105

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WBGene00019105	SMap	S_parent	Sequence	F59D6
	Identity	Version	2
		Name	CGC_name	asp-8	Person_evidence	WBPerson261
			Sequence_name	F59D6.3
			Molecular_name	F59D6.3
				F59D6.3.1
				CE51092
			Other_name	CELE_F59D6.3	Accession_evidence	NDB	BX284605
			Public_name	asp-8
		DB_info	Database	AceView	gene	5D505
				WormQTL	gene	WBGene00019105
				WormFlux	gene	WBGene00019105
				NDB	locus_tag	CELE_F59D6.3
				Panther	gene	CAEEL\|WormBase=WBGene00019105\|UniProtKB=O16338
					family	PTHR13683
				NCBI	gene	178750
				RefSeq	protein	NM_071424.7
				TREEFAM	TREEFAM_ID	TF315800
				TrEMBL	UniProtAcc	O16338
				UniProt_GCRP	UniProtAcc	O16338
		Species	Caenorhabditis elegans
		History	Version_change	1	28 May 2004 13:31:01	WBPerson1971	Event	Imported	Initial conversion from CDS class of stlace from WS125
				2	23 Nov 2012 14:10:21	WBPerson2970	Name_change	CGC_name	asp-8
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	asp
		Allele (131)
		RNASeq_FPKM (74)
		GO_annotation	00027884
			00027885
			00027886
			00124038
			00124039
		Ortholog (58)
		Paralog (17)
		Structured_description	Automated_description	Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in lysosome. Is an ortholog of human PGC (progastricsin).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	F59D6.3
		Corresponding_CDS_history	F59D6.3:wp250
		Corresponding_transcript	F59D6.3.1
		Other_sequence	CBC01221_1
		Associated_feature	WBsf231543
	Experimental_info	RNAi_result	WBRNAi00049176	Inferred_automatically	RNAi_primary
			WBRNAi00002198	Inferred_automatically	RNAi_primary
			WBRNAi00076507	Inferred_automatically	RNAi_primary
			WBRNAi00089097	Inferred_automatically	RNAi_primary
			WBRNAi00016096	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1152922
			Expr2009472
		Drives_construct	WBCnstr00026061
		Construct_product	WBCnstr00026061
		Microarray_results	SMD_F59D6.3
			189660_at
			A_12_P106590
			Aff_F59D6.3
			GPL13394_WBGene00019105
			GPL13914_F59D6.3
			GPL19516_CGZ0025587
			GPL21109_F59D6.3
			GPL3518_CE11480
			GPL8304_CE_WBGene00019105_A
			GPL8673_F59D6_3P00551
			GPL8673_F59D6_3P00945
			GPL8673_F59D6_3P01287
			GPL9450_F59D6.3
			cea2.p.119644
		Expression_cluster	WBPaper00029047:atx-3_upregulated
			WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00032425:up_in_alg-1
			WBPaper00032528:L3_enriched
			WBPaper00033065:cyc-1(RNAi)_upregulated
			WBPaper00033065:isp-1-1(qm150)_upregulated
			WBPaper00035269:cde-1_regulated
			WBPaper00036738:4uM_Heme_upregulated
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:all-neurons_L1-larva_expressed
			WBPaper00037950:AVA-neuron_L1-larva_expressed
			WBPaper00037950:AVE-neuron_L1-larva_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:coelomocytes_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:intestine_larva_enriched
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00038168:lin-15B(n744)_downregulated
			WBPaper00038237:age-1_upregulated_intestine_rescue
			WBPaper00038237:age-1_upregulated_neuron_rescue
			WBPaper00038237:age-1_upregulated_nontransgenic
			WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
			WBPaper00040285:H2S_24hr_downregulated
			WBPaper00040560:hpl-2_L3_downregulated
			WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated
			WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
			WBPaper00041954:ethanol_upregulated
			WBPaper00042215:wdr-23(tm1817)_upregulated
			WBPaper00042561:smgl-2(RNAi)_upregulated
			WBPaper00044246:pgrn-1_ced-3_ced-1_downregulated
			WBPaper00044316:CH3HgCl_7.5uM_downregulated
			WBPaper00044426:rotenone_24h_upregulated
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044578:reduced-humidity_downregulated_microarray
			WBPaper00044656:tatn-1(qd182)_upregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044857:BAR-1_upregulated
			WBPaper00045390:ubc-9(RNAi)_upregulated
			WBPaper00045401:N.parisii_64h_downregulated
			WBPaper00045420:fertilization_downregulated_transcript
			WBPaper00045774:clk-1_upregulated
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
			WBPaper00047131:daf-2(e1370)_upregulated_N2-background
			WBPaper00047132:glp-1(ts)-25C_upregulated
			WBPaper00048923:Aging_regulated
			WBPaper00048952:glucose_repressed
			WBPaper00048971:daf-16(mgDf50)_upregulated_L1
			WBPaper00049018:swsn-2.2(RNAi)_upregulated
			WBPaper00049098:heat-repressed_hrde-1(tm1200)
			WBPaper00049098:heat-repressed_N2
			WBPaper00049217:DAF-16_upregulated
			WBPaper00049495:starvation-refeeding_regulated
			WBPaper00049498:npr-1(ur89)_regulated_7
			WBPaper00049545:cco-1(RNAi)_upregulated
			WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
			WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
			WBPaper00049905:Age_variant_expression
			WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
			WBPaper00049920:Glucose-Diet_upregulated_N2
			WBPaper00049920:hyl-2(tm2031)_upregulated
			WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
			WBPaper00049942:hsf-1(RNAi)_downregulated
			WBPaper00050080:rbr-2(tm3141)_upregulated
			WBPaper00050121:mir-60(n4947)_upregulated
			WBPaper00050193:cec-4(ok3124)_downregulated_L1
			WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
			WBPaper00050370:dpy-21(e428)_L3_downregulated
			WBPaper00050370:mys-1(RNAi)_L3_upregulated
			WBPaper00050412:cco-1(RNAi)_upregulated_lin-65(n3441)
			WBPaper00050412:cco-1(RNAi)_upregulated_met-2(ok2307)
			WBPaper00050412:cco-1(RNAi)_upregulated_N2
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050726:OsmoticStress_regulated_NoFood
			WBPaper00050743:elli-1(sam-3)_downregulated
			WBPaper00050801:DAF-12_dauer_regulome
			WBPaper00050801:DAF-16_dauer_regulome
			WBPaper00050801:DPY-21_dauer_regulome
			WBPaper00050801:SET-4_dauer_regulome
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00051069:isp-1(qm150)_upregulated
			WBPaper00051498:zinc-reduction_upregulated
			WBPaper00051558:aging_regulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053295:lin-22(icb38)_upregulated
			WBPaper00053295:lin-22(ot269)_upregulated
			WBPaper00053302:stavudine_72h_regulated
			WBPaper00053388:dauer_regulated_Cluster5
			WBPaper00053402:cco-1(RNAi)_upregulated
			WBPaper00053599:female_vs_male_downregulated
			WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
			WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
			WBPaper00053810:isp-1(qm150)_upregulated
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00053814:15C_downregulated_PY79
			WBPaper00053888:drh-3(rrr2)_downregulated
			WBPaper00054410:set-9(rw5)_downregulated
			WBPaper00054410:set-26(tm2467)_upregulated
			WBPaper00054872:egl-9(sa307)_downregulated
			WBPaper00055013:hmg-3(bar24)_upregulated
			WBPaper00055060:flr-1(RNAi)_upregulated
			WBPaper00055137:S.maltophilia_downregulated
			WBPaper00055226:ADR-2_target_adr-1(tm668)
			WBPaper00055226:ADR-2_target_N2
			WBPaper00055354:Psora-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Metformin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055386:eat-2(ad465)_upregulated
			WBPaper00055626:pry-1(mu38)_upregulated
			WBPaper00055862:antimycin_damt-1(gk961032)_regulated
			WBPaper00055941:atfs-1(et15)_upregulated
			WBPaper00055941:atfs-1(gk3094)_downregulated
			WBPaper00055941:nuo-6(qm200)_upregulated
			WBPaper00055944:C.butyricum_vs_OP50_upregulated
			WBPaper00055971:nhl-2(ok818)_20C_downregulated
			WBPaper00055971:nhl-2(ok818)_25C_downregulated
			WBPaper00056167:Cry5B_downregulated
			WBPaper00056167:ifo-1(kc2)_upregulated
			WBPaper00056290:hsp-6(mg585)_upregulated
			WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00056586:kri-1(ok1251)_downregulated
			WBPaper00056619:CEPsh_enriched
			WBPaper00056809:smn-1(ok355)_downregulated
			WBPaper00056826:hmc_biased
			WBPaper00057041:spc-1(cas971)_downregulated
			WBPaper00057041:unc-70(cas983)_downregulated
			WBPaper00057068:ints-4(RNAi)_downregulated
			WBPaper00057068:numr-1(RNAi)_downregulated
			WBPaper00057154:HeatShock_downregulated_mRNA
			WBPaper00057265:metaformin_downregulated_OP50-MR
			WBPaper00058711:paraquat_upregulated
			WBPaper00058948:PA14_downregulated
			WBPaper00059117:B.subtilis_upregulated
			WBPaper00059194:klf-1(RNAi)_regulated
			WBPaper00059224:tph-1(mg280)_downregulated
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059334:sacy-1(depletion)_regulated
			WBPaper00059421:daf-1(m40)_upregulated
			WBPaper00059421:daf-3(mgDf90)_downregulated
			WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
			WBPaper00059604:fluvastatin_downregulated_N2
			WBPaper00059728:5ug_cholesterol_upregulated
			WBPaper00059728:20ug_cholesterol_upregulated
			WBPaper00059735:glucose_downregulated_N2
			WBPaper00059739:hira-1(gk835598)_downregulated_adult
			WBPaper00059739:hira-1(gk835598)_downregulated_L4
			WBPaper00059824:rnp-6(dh1127)_regulated_OP50
			WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
			WBPaper00059895:wounding_downregulated
			WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
			WBPaper00060084:cco-1(RNAi)_upregulated_N2
			WBPaper00060224:atf-6(ok551)_downregulated
			WBPaper00060273:isp-1(qm150)_upregulated
			WBPaper00060278:atp-2(RNAi)_upregulated
			WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060399:CoCl2_6hr_upregulated_N2
			WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060703:nas-38(ok3407)_downregulated
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00060909:atfs-1(et18)_upregulated
			WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
			WBPaper00060911:prx-5(RNAi)_upregulated_protein
			WBPaper00060951:metr-1(os521)_upregulated
			WBPaper00061007:HB101_upregulated
			WBPaper00061007:S.aquatilis_upregulated
			WBPaper00061045:Y56A3A.22(cck200)_upregulated
			WBPaper00061341:28C_24h_downregulated
			WBPaper00061341:28C_48h_downregulated
			WBPaper00061390:N2_ascarosides_upregulated
			WBPaper00061405:S.aureus_downregulated_starvation
			WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
			WBPaper00061439:unc-30(ok613)_upregulated
			WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
			WBPaper00061466:nath-10(icb102)_downregulated
			WBPaper00061527:mup-2-unc-87_284
			WBPaper00061590:CGP37157_upregulated
			WBPaper00061651:Rectal_gland_enriched
			WBPaper00061692:acivicin_upregulated
			WBPaper00061753:csr-1(tor159)_upregulated_25C
			WBPaper00062056:lin-37(n758)_downregulated
			WBPaper00062078:NMR-HspB1_regulated
			WBPaper00062184:PA14_upregulated
			WBPaper00062193:skn-1(RNAi)_upregulated
			WBPaper00062237:dnj-21(RNAi)_upregulated_protein
			WBPaper00062293:clk-1(qm30)_upregulated
			WBPaper00062293:isp-1(qm150)_upregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062440:crh-1(syb385)_upregulated
			WBPaper00062446:nhr-8(hd117)_downregulated
			WBPaper00062446:nhr-8(ok186)_downregulated
			WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
			WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
			WBPaper00064005:starvation_downregulated_N2_mRNA
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
			WBPaper00064156:lipl-4(overexpress)_upregulated
			WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
			WBPaper00064505:tamoxifen_downregulated
			WBPaper00064532:pals-22(jy3)_downregulated
			WBPaper00064602:egl-9(sa307)_downregulated
			WBPaper00064637:cox-5B(RNAi)_upregulated
			WBPaper00064661:lpd-3(ok2138)_downregulated
			WBPaper00064716:paraquat_downregulated
			WBPaper00064999:miR-229-64-65-66_downregulated
			WBPaper00065029:cadmium_upregulated
			WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
			WBPaper00065074:glna(-)_upregulated
			WBPaper00065086:JU1400_N.ferruginous_regulated
			WBPaper00065096:25C_vs_20C_downregulated
			WBPaper00065096:Day10_vs_Day1_downregulated
			WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
			WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
			WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
			WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
			WBPaper00065272:dhgd-1(tm6671)_upregulated
			WBPaper00065392:Lb.delbrueckii_upregulated
			WBPaper00065392:Lb.plantarum_upregulated
			WBPaper00065392:Lb.reuteri_upregulated
			WBPaper00065392:Lb.rhamnosus_upregulated
			WBPaper00065392:P.pentosaceus_upregulated
			WBPaper00065734:unc-25(e156)_upregulated
			WBPaper00065749:endu-2(tm4977)_upregulated
			WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
			WBPaper00065841:3_4
			WBPaper00065841:3_5
			WBPaper00065841:30_0
			WBPaper00065841:30_3
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065984:pals-17(syb3980)_downregulated
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066093:E.coli-purE_upregulated
			WBPaper00066110:Cisplatin_upregulated_diploid
			WBPaper00066110:Doxorubicin_upregulated_diploid
			WBPaper00066110:tetraploid_vs_diploid_upregulated
			WBPaper00066163:crtc-1(wbm18)_downregulated_set-2(ok952)
			WBPaper00066163:set-2(ok952)_upregulated_N2
			cgc4489_group_2
			WBPaper00026629:L4_hermaphrodite_enriched
			WBPaper00030985:Enterococcus_faecalis_upregulated
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00031703:heme_responsive_2
			WBPaper00034757:up_by_oxidative_stress
			WBPaper00035479:daf-16(RNAi)_upregulated
			WBPaper00035588:alg-1(-)_upregulated
			WBPaper00036130:mir-243_down_regulated
			WBPaper00036286:Pattern_C
			WBPaper00036375:depleted_in_PVD_OLL
			WBPaper00038304:octr-1_regulated
			WBPaper00040184:hcf-1up_sir-2.1down_daf-2nc
			WBPaper00040858:eQTL_regulated_juvenile
			WBPaper00040998:nhr-66_regulated
			WBPaper00041002:HF_3d_0.2mM_Up
			WBPaper00041002:HF_3d_2.0mM_Up
			WBPaper00041002:HF_11d_0.2mM_Up
			WBPaper00041002:HF_11d_2.0mM_Up
			WBPaper00041211:RPW-24_Up
			WBPaper00041370:spg-7(RNAi)_upregulated
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00042258:DA1877_upregulated_GravidAdult
			WBPaper00044091:Bpseudomallei_repressed_12h
			WBPaper00044535:male_downregulated
			WBPaper00045015:nhr-25(RNAi)_downregulated
			WBPaper00045263:0.1mM-paraquat_downregulated
			WBPaper00045263:isp-1(qm150)_upregulated
			WBPaper00045263:nuo-6(qm200)_upregulated
			WBPaper00045673:colistin_upregulated
			WBPaper00046083:ogt-1(ok1474)_OP50_upregulated
			WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
			WBPaper00047070:xpa-1_UV_upregulated
			WBPaper00049311:AgNO3_regulated
			WBPaper00049311:sAg-MNP_regulated
			WBPaper00056330:mrps-5(RNAi)_upregulated
		Interaction (75)
	Map_info	Map	V	Position	-12.796
		Positive	Positive_clone	F59D6	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference	WBPaper00038491
		WBPaper00055090
		WBPaper00059755
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene