WormBase Tree Display for Gene: WBGene00000794

WBGene00000794 Evidence: Paper_evidence: WBPaper00005857
  SMap: S_parent: Sequence: Y47G6A
  Identity: Version: 1
    Name: CGC_name: crn-1 Person_evidence: WBPerson1606
      Sequence_name: Y47G6A.8
      Molecular_name: Y47G6A.8
        Y47G6A.8.1
        CE22109
      Other_name: fen-1 Paper_evidence: WBPaper00036708
        CELE_Y47G6A.8 Accession_evidence: NDB BX284601
      Public_name: crn-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: crn
    Allele (53)
    RNASeq_FPKM (74)
    GO_annotation (37)
    Ortholog (40)
    Paralog: WBGene00009731 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020442 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019004 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: crn-1 encodes a cell death-related nuclease and is a 5'-3' exonuclease, a protein homologous to mammalian flap endonuclease 1 (FEN1); crn-1 also has endonuclease activity; crn-1 is essential for embryonic development and promotes cell death; CRN-1 binds the endonuclease CPS-6 in interaction experiments and each of these proteins can enhance the others's endonuclease activity; crn-1 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-5, crn-4, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-1 is ubiquitously expressed and localizes to the nucleus. Paper_evidence: WBPaper00005857
            WBPaper00005978
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Oct 2010 00:00:00
      Automated_description: Enables flap endonuclease activity. Involved in apoptotic DNA fragmentation. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human FEN1 (flap structure-specific endonuclease 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3650)
  Molecular_info: Corresponding_CDS: Y47G6A.8
    Corresponding_transcript: Y47G6A.8.1
    Other_sequence (45)
    Associated_feature: WBsf656120
      WBsf217401
      WBsf217402
  Experimental_info: RNAi_result (51)
    Expr_pattern: Expr2585
      Expr11817
      Expr1025800
      Expr1030493
      Expr1160283
      Expr2010536
      Expr2028776
    Drives_construct: WBCnstr00010862
      WBCnstr00019439
      WBCnstr00037272
    Construct_product: WBCnstr00010862
      WBCnstr00019439
      WBCnstr00037272
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049290:rsks-1(sv31)_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:ADA_ADE_grandparent
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064789:Day9_vs_Day1_downregulated_neuron
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_2
      cgc4489_group_1
      WBPaper00025032:cluster_58
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction: WBInteraction000002161
      WBInteraction000002163
      WBInteraction000002952
      WBInteraction000009720
      WBInteraction000028698
      WBInteraction000028935
      WBInteraction000030058
      WBInteraction000030069
      WBInteraction000030187
      WBInteraction000033184
      WBInteraction000034456
      WBInteraction000034475
      WBInteraction000035048
      WBInteraction000035049
      WBInteraction000035050
      WBInteraction000035951
      WBInteraction000039595
      WBInteraction000039756
      WBInteraction000040014
      WBInteraction000040015
      WBInteraction000040337
      WBInteraction000040338
      WBInteraction000040339
      WBInteraction000041426
      WBInteraction000041849
      WBInteraction000042139
      WBInteraction000043412
      WBInteraction000043478
      WBInteraction000044442
      WBInteraction000044443
      WBInteraction000046182
      WBInteraction000046769
      WBInteraction000046909
      WBInteraction000047958
      WBInteraction000049445
      WBInteraction000049496
      WBInteraction000049497
      WBInteraction000049769
      WBInteraction000049930
      WBInteraction000050037
      WBInteraction000102970
      WBInteraction000106236
      WBInteraction000107014
      WBInteraction000107101
      WBInteraction000108923
      WBInteraction000113238
      WBInteraction000116081
      WBInteraction000120628
      WBInteraction000120763
      WBInteraction000133736
      WBInteraction000133737
      WBInteraction000136476
      WBInteraction000136810
      WBInteraction000142094
      WBInteraction000143647
      WBInteraction000148408
      WBInteraction000150039
      WBInteraction000150661
      WBInteraction000156324
      WBInteraction000156355
      WBInteraction000157344
      WBInteraction000160044
      WBInteraction000161934
      WBInteraction000162585
      WBInteraction000165514
      WBInteraction000165524
      WBInteraction000165534
      WBInteraction000167020
      WBInteraction000168414
      WBInteraction000169395
      WBInteraction000169416
      WBInteraction000172930
      WBInteraction000175688
      WBInteraction000176628
      WBInteraction000179769
      WBInteraction000183811
      WBInteraction000184174
      WBInteraction000190488
      WBInteraction000190723
      WBInteraction000192064
      WBInteraction000193370
      WBInteraction000199233
      WBInteraction000200620
      WBInteraction000202140
      WBInteraction000204891
      WBInteraction000215875
      WBInteraction000218201
      WBInteraction000219259
      WBInteraction000222991
      WBInteraction000230150
      WBInteraction000230187
      WBInteraction000232425
      WBInteraction000240213
      WBInteraction000252307
      WBInteraction000264867
      WBInteraction000270093
      WBInteraction000271468
      WBInteraction000281632
      WBInteraction000288357
      WBInteraction000310067
      WBInteraction000316144
      WBInteraction000319394
      WBInteraction000337458
      WBInteraction000341003
      WBInteraction000344565
      WBInteraction000344566
      WBInteraction000350750
      WBInteraction000359401
      WBInteraction000363678
      WBInteraction000373226
      WBInteraction000377373
      WBInteraction000394008
      WBInteraction000394609
      WBInteraction000402495
      WBInteraction000403546
      WBInteraction000422255
      WBInteraction000447453
      WBInteraction000452390
      WBInteraction000452391
      WBInteraction000458191
      WBInteraction000462430
      WBInteraction000463245
      WBInteraction000464478
      WBInteraction000464479
      WBInteraction000464480
      WBInteraction000464481
      WBInteraction000464482
      WBInteraction000464483
      WBInteraction000464484
      WBInteraction000464485
      WBInteraction000464486
      WBInteraction000464513
      WBInteraction000464573
      WBInteraction000465058
      WBInteraction000465339
      WBInteraction000465467
      WBInteraction000465527
      WBInteraction000466554
      WBInteraction000468367
      WBInteraction000468576
      WBInteraction000468577
      WBInteraction000469003
      WBInteraction000469694
      WBInteraction000470609
      WBInteraction000470610
      WBInteraction000470720
      WBInteraction000471915
      WBInteraction000472064
      WBInteraction000472473
      WBInteraction000472490
      WBInteraction000472593
      WBInteraction000472674
      WBInteraction000473114
      WBInteraction000473838
      WBInteraction000474178
      WBInteraction000474792
      WBInteraction000474991
      WBInteraction000474992
      WBInteraction000475074
      WBInteraction000475345
      WBInteraction000504471
      WBInteraction000518091
      WBInteraction000518135
      WBInteraction000518174
      WBInteraction000518213
      WBInteraction000518262
      WBInteraction000518299
      WBInteraction000521775
      WBInteraction000521776
      WBInteraction000521777
      WBInteraction000521778
      WBInteraction000521779
      WBInteraction000521780
      WBInteraction000538949
      WBInteraction000541038
      WBInteraction000541428
      WBInteraction000541433
      WBInteraction000541437
      WBInteraction000541438
      WBInteraction000541439
      WBInteraction000541440
      WBInteraction000541441
      WBInteraction000541442
      WBInteraction000541445
      WBInteraction000541451
      WBInteraction000541456
      WBInteraction000541459
      WBInteraction000559614
      WBInteraction000564996
      WBInteraction000575064
    WBProcess: WBbiopr:00000014
      WBbiopr:00000103
  Map_info: Map: I Position: -3.20961 Error: 0.004142
    Positive: Positive_clone: Y47G6A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene