| WBGene00000776 | Evidence | Paper_evidence | WBPaper00004821 |
|---|
| SMap | S_parent | Sequence | T03E6 |
| Identity | Version | 1 |
| | Name | CGC_name | cpl-1 |
| | | Sequence_name | T03E6.7 |
| | | Molecular_name | T03E6.7a |
| | | | T03E6.7a.1 |
| | | | CE16333 |
| | | | T03E6.7b |
| | | | CE47424 |
| | | | T03E6.7b.1 |
| | | Other_name | CELE_T03E6.7 | Accession_evidence | NDB | BX284605 |
| | | Public_name | cpl-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cpl |
| | Allele (188) |
| | Strain | WBStrain00035678 |
| | RNASeq_FPKM (74) |
| | GO_annotation (34) |
| | Ortholog (69) |
| | Paralog (28) |
| | Structured_description | Concise_description | cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. | Paper_evidence | WBPaper00005099 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00011657 |
| | | | | | WBPaper00023209 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2537) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2537) |
| Molecular_info | Corresponding_CDS | T03E6.7a |
| | | T03E6.7b |
| | Corresponding_transcript | T03E6.7a.1 |
| | | T03E6.7b.1 |
| | Other_sequence (287) |
| | Associated_feature (13) |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern (17) |
| | Drives_construct | WBCnstr00002531 |
| | | WBCnstr00010433 |
| | | WBCnstr00010434 |
| | | WBCnstr00019401 |
| | | WBCnstr00037285 |
| | Construct_product | WBCnstr00010434 |
| | | WBCnstr00015512 |
| | | WBCnstr00016652 |
| | | WBCnstr00018463 |
| | | WBCnstr00018464 |
| | | WBCnstr00019401 |
| | | WBCnstr00037285 |
| | Regulate_expr_cluster | WBPaper00064728:cpl-1(W32AY35A)_upregulated |
| | Antibody | WBAntibody00000451 |
| | | WBAntibody00000800 |
| | | WBAntibody00000801 |
| | | WBAntibody00000802 |
| | | WBAntibody00000803 |
| | | WBAntibody00002885 |
| | | WBAntibody00002910 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00005700:secreted_protein |
| | | WBPaper00026640:Development_Group_II |
| | | WBPaper00026640:embryo-to-L1_downregulated |
| | | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1353 |
| | | WBPaper00029359_1419 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1548 |
| | | WBPaper00029359_1604 |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00031674:feh-1(gb561)(RNAi)_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033444:BacteriaDiet_regulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044128:daf-2(e1370)_downregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045861:ash-2(tm1095)_upregulated |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00046121:endoderm_unique |
| | | WBPaper00046446:rapid-synthesized_YoungAdult |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046795:starvation_downregulated |
| | | WBPaper00048644:germline_enriched |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:ham-3(RNAi)_downregulated |
| | | WBPaper00049018:swsn-2.2(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050053:muscle_enriched_Day12 |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050636:aging_regulated_insoluble_protein |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_downregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055013:HMG-3_interacting_protein |
| | | WBPaper00055013:HMG-4_interacting_protein |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055969:electromagnetic-field_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056290:mdt-15(mg584)_upregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056900:ERH-2_interacting |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00056997:NMAD-1_interacting |
| | | WBPaper00058711:wdr-5(ok1417)_downregulated |
| | | WBPaper00058942:henn-1(pk2295)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059254:CSR-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059440:GLP-1_activated |
| | | WBPaper00059440:LAG-1_activated_48hr-auxin |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060683:hlh-11(overexpression)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:Intestine |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:COX3-ND1 |
| | | WBPaper00061527:R10H10.3-T21H3.1 |
| | | WBPaper00061692:acivicin_downregulated |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064201:SNA-1_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-3(bn199)_downregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_upregulated_F2 |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065199:Transgeneration-starvation_regulated_fed |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:4_0 |
| | | WBPaper00065841:4_1 |
| | | WBPaper00065841:4_2 |
| | | WBPaper00065841:38_1 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4386_cluster_2_3 |
| | | cgc4489_group_25 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00025032:cluster_5 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027758:Group_II |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038172:crh-1null_down_regulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(83_min) |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:mixed_spermatogenesis-somatic |
| | Interaction | WBInteraction000028633 |
| | | WBInteraction000028996 |
| | | WBInteraction000030179 |
| | | WBInteraction000030180 |
| | | WBInteraction000040898 |
| | | WBInteraction000160924 |
| | | WBInteraction000162872 |
| | | WBInteraction000162873 |
| | | WBInteraction000162874 |
| | | WBInteraction000162875 |
| | | WBInteraction000162876 |
| | | WBInteraction000167065 |
| | | WBInteraction000169108 |
| | | WBInteraction000185647 |
| | | WBInteraction000186518 |
| | | WBInteraction000186724 |
| | | WBInteraction000187504 |
| | | WBInteraction000188993 |
| | | WBInteraction000190070 |
| | | WBInteraction000203585 |
| | | WBInteraction000218070 |
| | | WBInteraction000218114 |
| | | WBInteraction000219929 |
| | | WBInteraction000225317 |
| | | WBInteraction000226306 |
| | | WBInteraction000228925 |
| | | WBInteraction000232845 |
| | | WBInteraction000235662 |
| | | WBInteraction000236929 |
| | | WBInteraction000245472 |
| | | WBInteraction000255701 |
| | | WBInteraction000261097 |
| | | WBInteraction000271366 |
| | | WBInteraction000302205 |
| | | WBInteraction000314496 |
| | | WBInteraction000332981 |
| | | WBInteraction000360670 |
| | | WBInteraction000361715 |
| | | WBInteraction000365374 |
| | | WBInteraction000369426 |
| | | WBInteraction000376975 |
| | | WBInteraction000384096 |
| | | WBInteraction000398414 |
| | | WBInteraction000398592 |
| | | WBInteraction000406099 |
| | | WBInteraction000408603 |
| | | WBInteraction000421516 |
| | | WBInteraction000432881 |
| | | WBInteraction000442114 |
| | | WBInteraction000444165 |
| | | WBInteraction000446972 |
| | | WBInteraction000447240 |
| | | WBInteraction000461512 |
| | | WBInteraction000461844 |
| | | WBInteraction000500995 |
| | | WBInteraction000501003 |
| | | WBInteraction000501004 |
| | | WBInteraction000501005 |
| | | WBInteraction000501006 |
| | | WBInteraction000501562 |
| | | WBInteraction000501564 |
| | | WBInteraction000514898 |
| | | WBInteraction000514925 |
| | | WBInteraction000514931 |
| | | WBInteraction000523303 |
| | | WBInteraction000536473 |
| | | WBInteraction000536545 |
| | | WBInteraction000536755 |
| | | WBInteraction000536758 |
| | | WBInteraction000536760 |
| | | WBInteraction000536763 |
| | | WBInteraction000536765 |
| | | WBInteraction000538994 |
| | | WBInteraction000539819 |
| | | WBInteraction000543812 |
| | | WBInteraction000543840 |
| | | WBInteraction000544043 |
| | | WBInteraction000544352 |
| | | WBInteraction000550978 |
| | | WBInteraction000556618 |
| | | WBInteraction000558611 |
| | | WBInteraction000558781 |
| | | WBInteraction000560180 |
| | | WBInteraction000560509 |
| | | WBInteraction000560796 |
| | | WBInteraction000560892 |
| | | WBInteraction000562235 |
| | | WBInteraction000562425 |
| | | WBInteraction000562717 |
| | | WBInteraction000566016 |
| | | WBInteraction000566489 |
| | | WBInteraction000566768 |
| | | WBInteraction000569415 |
| | | WBInteraction000570142 |
| | | WBInteraction000570655 |
| | | WBInteraction000572394 |
| | | WBInteraction000572933 |
| | | WBInteraction000574026 |
| | | WBInteraction000574944 |
| | | WBInteraction000576114 |
| | | WBInteraction000577511 |
| | | WBInteraction000579920 |
| | | WBInteraction000581954 |
| | | WBInteraction000582501 |
| | | WBInteraction000582861 |
| | | WBInteraction000585294 |
| | | WBInteraction000586090 |
| Map_info | Map | V | Position | 10.72 |
| | Positive | Positive_clone | T03E6 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4236 |
| | Pseudo_map_position |
| Reference (37) |
| Remark | Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| | [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333) |
| Method | Gene |
