| WBGene00004856 | SMap | S_parent | Sequence | CHROMOSOME_III |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | sma-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK370.2 |
| | | Molecular_name | ZK370.2a |
| | | | ZK370.2a.1 |
| | | | CE33015 |
| | | | ZK370.2b |
| | | | CE53267 |
| | | | ZK370.2a.2 |
| | | | ZK370.2b.1 |
| | | Other_name | cem-1 |
| | | | CELE_ZK370.2 | Accession_evidence | NDB | BX284603 |
| | | Public_name | sma-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sma |
| | Reference_allele | WBVar00143257 |
| | Allele (121) |
| | Legacy_information | e502 : short somewhat dumpy; males have crumpled spicules; synthetic lethal with some morphological mutants. ES3 (adult) ME0. NA4 (e172 e297 etc.). |
| | | See also e297 |
| | | [C.elegansII] e502 : short, somewhat dumpy; males have crumpled spicules, abnormal rays; synthetic lethal with some morphological mutants; mosaic analysis indicates cell autonomous action. Similar to Sma-3, Sma-4, Daf-4. ES3 (adult) ME0. OA>5: e172, e297, e1491(weaker), s262 (induced on eT1) etc. Cloned: encodes DWARFIN [Baird et al. 1991; LT; PB] |
| | Strain (13) |
| | RNASeq_FPKM (74) |
| | GO_annotation (31) |
| | Ortholog (68) |
| | Paralog | WBGene00000899 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00000904 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000910 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004857 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004858 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006445 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | sma-2 encodes, along with sma-3 and sma-4, one of three C. elegans Smad proteins, with SMA-2 and SMA-3 most closely related to receptor-regulated Smads (R-Smads) and SMA-4 more closely related to co-mediator Smads (CoSmads); during development, SMA-2 functions in a TGF-beta signaling pathway to regulate body size and specification of sensory structures in the male tail; sma-2, through this pathway, also regulates reproductive aging; studies show that reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; a sma-2::gfp reporter is expressed in the pharynx, intestine, and hypodermis; SMA-2 protein interacts with DAF-16. | Paper_evidence | WBPaper00002374 |
| | | | | | WBPaper00026644 |
| | | | | | WBPaper00035556 |
| | | | | | WBPaper00037682 |
| | | | | | WBPaper00051279 |
| | | | | Person_evidence | WBPerson50 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 17 Jul 2017 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; positive regulation of cell growth; and regulation of anatomical structure morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 3; carcinoma (multiple); and reproductive organ cancer (multiple). Is an ortholog of human SMAD9 (SMAD family member 9). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (16) |
| Molecular_info | Corresponding_CDS | ZK370.2a |
| | | ZK370.2b |
| | Corresponding_CDS_history | ZK370.2:wp91 |
| | Corresponding_transcript | ZK370.2a.1 |
| | | ZK370.2a.2 |
| | | ZK370.2b.1 |
| | Other_sequence (74) |
| | Associated_feature (11) |
| | Transcription_factor | WBTranscriptionFactor001120 |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern | Chronogram1005 |
| | | Expr7207 |
| | | Expr1011006 |
| | | Expr1032408 |
| | | Expr1162804 |
| | | Expr2015892 |
| | | Expr2034125 |
| | Drives_construct | WBCnstr00001867 |
| | | WBCnstr00001868 |
| | | WBCnstr00001869 |
| | | WBCnstr00003254 |
| | | WBCnstr00035354 |
| | Construct_product | WBCnstr00001867 |
| | | WBCnstr00001868 |
| | | WBCnstr00001869 |
| | | WBCnstr00035354 |
| | | WBCnstr00038798 |
| | Regulate_expr_cluster | WBPaper00037682:sma-2_downregulated |
| | | WBPaper00037682:sma-2_sma-4_downregulated |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00029359_1166 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1311 |
| | | WBPaper00029359_1320 |
| | | WBPaper00029359_1326 |
| | | WBPaper00029359_1345 |
| | | WBPaper00029359_1357 |
| | | WBPaper00029359_1435 |
| | | WBPaper00029359_1439 |
| | | WBPaper00029359_1458 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00029359_1618 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037946:MAB-5_interacting |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AMso |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:nhr-18-C34D1.4_6256 |
| | | WBPaper00061527:T16H12.9-kin-9_20752 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:daf-16(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065841:78_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | cgc4489_group_5 |
| | | cgc4489_group_21 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:Q200_up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (247) |
| | WBProcess | WBbiopr:00000025 |
| | | WBbiopr:00000039 |
| Map_info | Map | III | Position | -0.072089 | Error | 0.00314 |
| | Well_ordered |
| | Positive | Positive_clone | PAR2 |
| | | | ZK370 | Author_evidence | Savage C |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | tnDf2 |
| | Mapping_data | 2_point (17) |
| | | Multi_point (43) |
| | | Pos_neg_data (10) |
| Reference (168) |
| Picture | WBPicture0000013077 |
| Remark | [Savage C] sma-2 cDNA spans ZK370 and pAR2, and includes most of the Genefinder predicted ORF ZK370.2 |
| | cem-1 appears to be the same gene as this. The two sequences PAR2.2 and ZK370.2 come from cem-1 and the positive clones. sdm 12/00 |
| | this gene crosses stl and cam boundary, hence predicted in 2 parts. sdm 01.01 |
| Method | Gene |
