WormBase Tree Display for Gene: WBGene00004374

WBGene00004374 SMap: S_parent: Sequence: T11F8
  Identity: Version: 1
    Name: CGC_name: rme-2 Person_evidence: WBPerson259
      Sequence_name: T11F8.3
      Molecular_name: T11F8.3a
        T11F8.3a.1
        CE22368
        T11F8.3b
        CE49356
        T11F8.3b.1
      Other_name: CELE_T11F8.3 Accession_evidence: NDB BX284604
      Public_name: rme-2
    DB_info: Database: AceView gene 4G237
        WormQTL gene WBGene00004374
        WormFlux gene WBGene00004374
        NDB locus_tag CELE_T11F8.3
        Panther gene CAEEL|WormBase=WBGene00004374|UniProtKB=O44191
          family PTHR46513
        NCBI gene 177329
        RefSeq protein NM_068414.7
            NM_001380231.1
        TrEMBL UniProtAcc V6CIR8
            O44191
        UniProt_GCRP UniProtAcc O44191
        OMIM gene 131530
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rme
    Allele (44)
    Legacy_information: [Grant BD] Brood size: 17. Endocytosis of YP170 GFP by oocytes absent. Abundant pseudocoelomic yolk.
    Strain: WBStrain00005828
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP4164
    Ortholog (48)
    Paralog: WBGene00008779 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003071 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003072 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003738 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008609 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015083 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019756 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019811 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020481 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: rme-2 encodes a member of the low-density lipoprotein (LDL) receptor superfamily; RME-2 functions as the C. elegans yolk receptor whose activity is required for yolk uptake during oogenesis; RME-2 is expressed in developing oocytes where it localizes at or near the cell surface. Paper_evidence: WBPaper00003831
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Jul 2007 00:00:00
      Automated_description: Enables low-density lipoprotein particle receptor activity. Involved in embryo development; oocyte development; and ovulation. Located in endosome membrane and plasma membrane. Expressed in germ cell; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; female reproductive organ cancer (multiple); hepatobiliary system cancer (multiple); and high grade glioma (multiple). Is an ortholog of human EGF (epidermal growth factor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (21)
  Modifies_disease: DOID:14175
  Modifies_disease_in_annotation: WBDOannot00000601
  Molecular_info: Corresponding_CDS: T11F8.3a
      T11F8.3b
    Corresponding_CDS_history: T11F8.3:wp86
    Corresponding_transcript: T11F8.3a.1
      T11F8.3b.1
    Other_sequence (30)
    Associated_feature (12)
  Experimental_info (9)
  Map_info: Map: IV Position: 1.68692 Error: 0.007682
    Well_ordered
    Positive: Inside_rearr: mDf4
        nDf41
      Positive_clone: T11F8 Author_evidence: sequence alterations,
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3827
        3828
        3829
        4614
      Pos_neg_data: 10282
        10284
  Reference (82)
  Method: Gene