WBGene00004271 | SMap | S_parent | Sequence | W03C9 |
| Identity | Version | 1 |
| | Name | CGC_name | rab-7 | Person_evidence | WBPerson451 |
| | | Sequence_name | W03C9.3 |
| | | Molecular_name | W03C9.3 |
| | | | W03C9.3.1 |
| | | | CE03777 |
| | | Other_name | CELE_W03C9.3 | Accession_evidence | NDB | BX284602 |
| | | Public_name | rab-7 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rab |
| | Allele (25) |
| | Possibly_affected_by | WBVar02154081 |
| | | WBVar02154082 |
| | Strain | WBStrain00035667 |
| | | WBStrain00048935 |
| | RNASeq_FPKM (74) |
| | GO_annotation (24) |
| | Contained_in_operon | CEOP2580 |
| | Ortholog (32) |
| | Paralog (32) |
| | Structured_description | Concise_description | rab-7 encodes a Rab GTPase orthologous to the Rab7 GTPases of yeast, Drosophila, and vertebrates; RAB-7 is required for endosome and endosome to lysosome trafficking and thus, for proper yolk protein transport in oocytes and transport of endocytosed materials in coelomoyctes; RAB-7 is also required for apoptotic cell clearance, particularly for regulation of lysosome to phagosome fusion; RAB-7 activity is also required for normal embryogenesis, locomotion, and body morphology; RAB-7 localizes to late endosomes, lysosomes, and phagosomes; RAB-7 localization, and presumably function, at endosomes is positively regulated by SAND-1, a novel, conserved protein required for early to late endosome maturation and transport; rab-7 activity is upregulated by tub-1/tubby, a gene involved in obesity across species, suggesting that rab-7 may also be involved in a tub-1/tubby mediated endocytic pathway for regulation of fat storage. | Paper_evidence | WBPaper00003831 |
| | | | | | WBPaper00004540 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00027709 |
| | | | | | WBPaper00028972 |
| | | | | | WBPaper00031612 |
| | | | | | WBPaper00037661 |
| | | | | | WBPaper00030935 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 11 Jan 2012 00:00:00 |
| | | Automated_description | Enables GTPase activity. Involved in several processes, including oocyte growth; positive regulation of early endosome to late endosome transport; and vesicle-mediated transport. Located in late endosome membrane; lysosome; and phagocytic vesicle membrane. Expressed in several structures, including oocyte. Used to study obesity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Is an ortholog of human RAB7A (RAB7A, member RAS oncogene family). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00030935 |
| | | | | Accession_evidence | OMIM | 601665 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 30 Jan 2013 00:00:00 |
| | Potential_model | DOID:0110159 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9788) |
| | Disease_relevance | Studies in C. elegans suggest that the small Rab GTPase RAB-7 and the Rab-GTPase-activating protein RBG-3 are involved in a tub-1/tubby mediated endocytic pathway that increases fat storage; tub-1/tubby is a gene involved in obesity across species; tub-1 also interacts with RBG-3 in ciliated neurons to possibly modulate neurohormonal and chemosensory function in the regulation of fat storage. | Homo sapiens | Paper_evidence | WBPaper00031329 |
| | | | | | WBPaper00038404 |
| | | | | Accession_evidence | OMIM | 203750 |
| | | | | | | 601665 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 12 Jan 2012 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000028 |
| Molecular_info | Corresponding_CDS | W03C9.3 |
| | Corresponding_transcript | W03C9.3.1 |
| | Other_sequence (45) |
| | Associated_feature | WBsf650634 |
| | | WBsf666217 |
| | | WBsf224016 |
| | | WBsf224017 |
| Experimental_info | RNAi_result (75) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00012363 |
| | | WBCnstr00020664 |
| | | WBCnstr00042405 |
| | Construct_product (36) |
| | Antibody | WBAntibody00001207 |
| | | WBAntibody00002256 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040285:H2S_24hr_upregulated |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:T23B5.3_15993-C17D12.1 |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064992:Eugenol_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027111:eri-1(mg366)_upregulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-exposed_24h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00044535:male_upregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (96) |
| | WBProcess | WBbiopr:00000015 |
| Map_info | Map | II | Position | 4.64486 | Error | 0.24308 |
| | Positive | Positive_clone | W03C9 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4619 |
| | Pseudo_map_position |
| Reference (132) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |