| WBGene00002368 | SMap | S_parent | Sequence | K08E7 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | let-99 | Person_evidence | WBPerson533 |
| | | Sequence_name | K08E7.3 |
| | | Molecular_name | K08E7.3 |
| | | | K08E7.3.1 |
| | | | CE06147 |
| | | Other_name | CELE_K08E7.3 | Accession_evidence | NDB | BX284604 |
| | | Public_name | let-99 |
| | DB_info | Database | AceView | gene | 4N335 |
| | | | WormQTL | gene | WBGene00002368 |
| | | | WormFlux | gene | WBGene00002368 |
| | | | NDB | locus_tag | CELE_K08E7.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00002368|UniProtKB=Q21341 |
| | | | | family | PTHR16206 |
| | | | NCBI | gene | 178210 |
| | | | RefSeq | protein | NM_070006.4 |
| | | | SwissProt | UniProtAcc | Q21341 |
| | | | TREEFAM | TREEFAM_ID | TF352206 |
| | | | UniProt_GCRP | UniProtAcc | Q21341 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | let |
| | Reference_allele | WBVar00241974 |
| | Allele (44) |
| | Legacy_information | Mel |
| | | See also s1201 |
| | | [Rose, LS] recessive maternal effect lethal: embryos from it141 homozygous mothers can exhibit altered spindle orientations in all cells during the first three cleavages. |
| | | [Rose, LS] maternal effect lethal: embryos from s1201 homozygous mothers can exhibit altered spindle orientations in all cells during the first three cleavages. |
| | | [C.elegansII] s1201 : Mel, s1201/Df similar. Incorrect spindle orientation in AB and P1. OA1. Cloned. [Clark et al. 1988; Charest et al. 1990; BC; KK] |
| | | [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. |
| | Complementation_data | [Rose, LS] it141 fails to complement let-99(s1201), complements let-97 |
| | | [Bowerman BA] fails to complement let-99(or60) fails to complement let-99(or81) |
| | Strain | WBStrain00002507 |
| | | WBStrain00034721 |
| | | WBStrain00034722 |
| | | WBStrain00036189 |
| | | WBStrain00000657 |
| | | WBStrain00007368 |
| | | WBStrain00007266 |
| | RNASeq_FPKM (74) |
| | GO_annotation (12) |
| | Ortholog (21) |
| | Paralog | WBGene00003067 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes |
| | | WBGene00011427 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00015342 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00016052 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00077693 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00016971 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position). | Paper_evidence | WBPaper00005515 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Involved in establishment of mitotic spindle orientation. Located in cell cortex. Expressed in embryonic cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | K08E7.3 |
| | Corresponding_transcript | K08E7.3.1 |
| | Other_sequence | CR09932 |
| | | CRC00926_1 |
| | Associated_feature | WBsf660821 |
| | | WBsf660822 |
| | | WBsf229308 |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern | Chronogram1102 |
| | | Expr2256 |
| | | Expr4507 |
| | | Expr4508 |
| | | Expr1016659 |
| | | Expr1031353 |
| | | Expr1154006 |
| | | Expr2013081 |
| | | Expr2031313 |
| | Drives_construct | WBCnstr00004437 |
| | | WBCnstr00004940 |
| | | WBCnstr00012068 |
| | | WBCnstr00019544 |
| | | WBCnstr00036329 |
| | Construct_product | WBCnstr00004940 |
| | | WBCnstr00010005 |
| | | WBCnstr00012068 |
| | | WBCnstr00019544 |
| | | WBCnstr00036329 |
| | Antibody | WBAntibody00000564 |
| | | WBAntibody00000702 |
| | | WBAntibody00002081 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00029359_1280 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00040560:hpl-2_L3_upregulated |
| | | WBPaper00041071:spe-44_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:rising_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPA_downregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L1 |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L4 |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:rect_D |
| | | WBPaper00061340:RID |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061527:let-99_22121-B0238.9_11154 |
| | | WBPaper00061527:let-99_22239-such-1 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_downregulated |
| | | WBPaper00062715:blmp-1(s71)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F2 |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | cgc4489_group_16 |
| | | WBPaper00025032:cluster_1 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00032165:A_to_C_transit_decreased |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-exposed_24h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00051387:Triclosan_downregulated |
| | | WBPaper00055435:AuNPs_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | | [cgc6390]:spermatogenesis-enriched |
| | Interaction (224) |
| | WBProcess | WBbiopr:00000017 |
| Map_info | Map | IV | Position | 6.02566 | Error | 0.007381 |
| | Well_ordered |
| | Positive | Positive_clone | C13H6 |
| | | | K08E7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 3321 |
| | | Multi_point | 1280 |
| | | | 1283 |
| | | | 4415 |
| | | | 4162 |
| | | | 5595 |
| | | Pos_neg_data (11) |
| Reference (75) |
| Remark | [BC Lab] Essential gene. Phenotype of homozygous s1201 is a maternal effect lethal. |
| Method | Gene |
