WormBase Tree Display for Gene: WBGene00011580

WBGene00011580 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 2
    Name: CGC_name: ddx-19 Person_evidence: WBPerson555
            WBPerson3232
      Sequence_name: T07D4.4
      Molecular_name (15)
      Other_name: CELE_T07D4.4 Accession_evidence: NDB BX284602
      Public_name: ddx-19
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Feb 2008 16:59:39 WBPerson2970 Name_change: CGC_name: ddx-19
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ddx
    Allele (58)
    Strain: WBStrain00003226
      WBStrain00031624
    RNASeq_FPKM (74)
    GO_annotation: 00006483
      00006484
      00006485
      00006486
      00006487
      00006488
      00006489
      00006490
      00006491
      00006492
      00006493
      00006494
      00006495
      00118814
      00118815
    Ortholog (48)
    Paralog (37)
    Structured_description: Concise_description: ddx-19 encodes a DEAD-box helicase; ddx-19(RNAi) in a mpk-1(ga111ts) mutant background results in germline developmental defects, including disruption of membrane organization in pachytene cells and disorganized oocytes; DDX-19 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo; consistent with this, DDX-19 phosphorylation is absent in mpk-1 mutant animals; DDX-19 localizes to perinuclear P granules. Paper_evidence: WBPaper00031057
            WBPaper00032961
            WBPaper00036048
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Jan 2012 00:00:00
      Automated_description: Predicted to enable RNA binding activity and RNA helicase activity. Involved in germ cell development. Located in P granule. Expressed in tail. Is an ortholog of human DDX19A (DEAD-box helicase 19A) and DDX19B (DEAD-box helicase 19B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T07D4.4a
      T07D4.4b
      T07D4.4c
      T07D4.4d
      T07D4.4e
    Corresponding_transcript: T07D4.4a.1
      T07D4.4b.1
      T07D4.4c.1
      T07D4.4d.1
      T07D4.4e.1
    Other_sequence (50)
    Associated_feature (19)
  Experimental_info: RNAi_result: WBRNAi00018369 Inferred_automatically: RNAi_primary
      WBRNAi00052760 Inferred_automatically: RNAi_primary
      WBRNAi00075465 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram2084
      Expr6629
      Expr9012
      Expr1010235
      Expr1035104
      Expr1156369
      Expr2010835
      Expr2029073
    Drives_construct: WBCnstr00003701
      WBCnstr00030544
    Construct_product: WBCnstr00030544
    Antibody: WBAntibody00002132
    Microarray_results (39)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032425:up_in_alg-1
      WBPaper00032425:up_in_lin-35
      WBPaper00032425:up_in_rde-4
      WBPaper00032425:up_in_zfp-1
      WBPaper00035269:cde-1_regulated
      WBPaper00037946:MAB-5_interacting
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050599:nicotine(1mM)_upregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059254:CSR-1_interacting
      WBPaper00059334:SACY-1_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061527:trcs-2_5724-R11A8.7_17645
      WBPaper00062123:GLH-1_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      cgc4489_group_1
      WBPaper00025032:cluster_43
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026629:L4_hermaphrodite_enriched
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040821:Au-NP_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (113)
  Map_info: Map: II Position: 0.92188 Error: 0.002109
    Positive: Positive_clone: T07D4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00030647
    WBPaper00032961
    WBPaper00036048
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene