WormBase Tree Display for Gene: WBGene00001017

WBGene00001017 SMap: S_parent: Sequence: ZK593
  Identity: Version: 1
    Name: CGC_name: dnc-1 Person_evidence: WBPerson689
      Sequence_name: ZK593.5
      Molecular_name (15)
      Other_name: CELE_ZK593.5 Accession_evidence: NDB BX284604
      Public_name: dnc-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dnc
    Allele (77)
    Possibly_affected_by: WBVar02153206
    Strain: WBStrain00007336
      WBStrain00007349
      WBStrain00024321
    RNASeq_FPKM (74)
    GO_annotation: 00008123
      00008124
      00008125
      00008126
      00008127
      00008128
      00008129
      00008130
      00008131
      00008132
      00008133
      00008134
      00008135
      00008136
      00008137
      00008138
      00008139
      00008140
      00008141
      00008142
      00008143
      00008144
      00008145
      00008146
      00008147
      00008148
      00008149
      00008150
      00008151
      00008155
      00008156
      00008157
      00008158
      00008159
      00008160
    Ortholog (40)
    Paralog: WBGene00009987 Caenorhabditis elegans From_analysis: Panther
      WBGene00010796 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: dnc-1 encodes the C. elegans ortholog of the dynactin complex subunit p150/GLUED/DCTN1; dnc-1 is required for pronuclear migration and centrosome separation in one-cell embryos and for the correct alignment of mitotic spindles in early embryos; DNC-1 shares embryonic functions with DNC-2, DHC-1, LIS-1 and NUD-1; DNC-1 is part of the multisubunit dynactin complex in vivo, and physically interacts specifically with the DNC-2 and DNC-3 dynactin subunits; DNC-1 is located at cortical microtubule attachment sites. Paper_evidence: WBPaper00003225
            WBPaper00003704
            WBPaper00004895
            WBPaper00018056
            WBPaper00037699
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 08 Aug 2012 00:00:00
      Automated_description: Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is an ortholog of human DCTN1 (dynactin subunit 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060486 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2711)
      DOID:0111202 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2711)
      DOID:0060193 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2711)
  Molecular_info: Corresponding_CDS: ZK593.5a
      ZK593.5b
      ZK593.5c
      ZK593.5d
      ZK593.5e
    Corresponding_CDS_history: ZK593.5:wp78
    Corresponding_transcript: ZK593.5a.1
      ZK593.5b.1
      ZK593.5c.1
      ZK593.5d.1
      ZK593.5e.1
    Other_sequence (13)
    Associated_feature (12)
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr1254
      Expr9603
      Expr15122
      Expr1016044
      Expr1030631
      Expr1162944
      Expr2010978
      Expr2029216
    Drives_construct: WBCnstr00037141
    Construct_product: WBCnstr00001381
      WBCnstr00007598
      WBCnstr00037141
    Antibody: WBAntibody00000192
      WBAntibody00001320
      WBAntibody00001493
      WBAntibody00002751
    Microarray_results (25)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044857:BAR-1_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00046691:AB_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Parents_of_U_F_B_DVA
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:klp-12-F10C2.5
      WBPaper00061527:mtr-4_1623-W03F9.10_103
      WBPaper00061527:utx-1_2886-swan-1_2192
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00064992:Eugenol_downregulated
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4386_cluster_6_2
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00025032:cluster_119
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_H
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00053688:E.faecium_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(41_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:herm_sex-enriched
    Interaction (183)
  Map_info: Map: IV Position: 4.75022 Error: 0.003469
    Positive: Positive_clone: ZK593 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4263
        5510
    Pseudo_map_position
  Reference (61)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene