WormBase Tree Display for Gene: WBGene00006915

WBGene00006915 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: vha-6
      Sequence_name: VW02B12L.1
      Molecular_name: VW02B12L.1
        VW02B12L.1.1
        CE18980
      Other_name: CELE_VW02B12L.1 Accession_evidence: NDB BX284602
      Public_name: vha-6
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vha
    Allele (54)
    Legacy_information: [Pujol N] vha-6 is expressed only in the intestine, from the embryonic coma stage through larvae and adult
    Strain: WBStrain00036524
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (58)
    Paralog: WBGene00006768 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006914 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006916 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: vha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cellsuntil the comma stage), on the apical surface of postembryonicintestinal cells, and at the junction between pharynx and intestine;VHA-6 is required for growth and survival past the L1 larval stage;vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do notgrow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-6 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane. Paper_evidence: WBPaper00004601
            WBPaper00004842
            WBPaper00025183
            WBPaper00028773
            WBPaper00028774
            WBPaper00028775
          Curator_confirmed: WBPerson567
          Date_last_updated: 19 Nov 2006 00:00:00
      Automated_description: Predicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (6)
  Molecular_info: Corresponding_CDS: VW02B12L.1
    Corresponding_transcript: VW02B12L.1.1
    Other_sequence (71)
    Associated_feature: WBsf650573
      WBsf650574
      WBsf989758
      WBsf1013237
      WBsf223933
  Experimental_info: RNAi_result (55)
    Expr_pattern: Expr851
      Expr2404
      Expr2407
      Expr13465
      Expr1029215
      Expr1032932
      Expr1158019
      Expr2017992
      Expr2036128
    Drives_construct: WBCnstr00000402
      WBCnstr00001781
      WBCnstr00001782
      WBCnstr00001784
      WBCnstr00001785
      WBCnstr00001789
      WBCnstr00001791
      WBCnstr00001796
      WBCnstr00001799
      WBCnstr00001802
      WBCnstr00001803
      WBCnstr00001813
      WBCnstr00001815
      WBCnstr00001816
      WBCnstr00001817
      WBCnstr00001818
      WBCnstr00001819
      WBCnstr00001820
      WBCnstr00001821
      WBCnstr00001823
      WBCnstr00001824
      WBCnstr00001825
      WBCnstr00005315
      WBCnstr00005338
      WBCnstr00005468
      WBCnstr00005469
      WBCnstr00005938
      WBCnstr00005940
      WBCnstr00005951
      WBCnstr00005952
      WBCnstr00005953
      WBCnstr00005984
      WBCnstr00006147
      WBCnstr00006148
      WBCnstr00006149
      WBCnstr00006150
      WBCnstr00006151
      WBCnstr00007127
      WBCnstr00007128
      WBCnstr00007129
      WBCnstr00007130
      WBCnstr00007131
      WBCnstr00007132
      WBCnstr00007133
      WBCnstr00007148
      WBCnstr00007165
      WBCnstr00007166
      WBCnstr00007167
      WBCnstr00007168
      WBCnstr00007169
      WBCnstr00007170
      WBCnstr00007171
      WBCnstr00007707
      WBCnstr00007723
      WBCnstr00007870
      WBCnstr00007872
      WBCnstr00008202
      WBCnstr00008203
      WBCnstr00008204
      WBCnstr00008209
      WBCnstr00008210
      WBCnstr00008212
      WBCnstr00008215
      WBCnstr00008216
      WBCnstr00008217
      WBCnstr00008229
      WBCnstr00008287
      WBCnstr00008288
      WBCnstr00008290
      WBCnstr00008647
      WBCnstr00008648
      WBCnstr00008736
      WBCnstr00008737
      WBCnstr00009081
      WBCnstr00009082
      WBCnstr00009083
      WBCnstr00009182
      WBCnstr00009183
      WBCnstr00009184
      WBCnstr00009186
      WBCnstr00009188
      WBCnstr00009189
      WBCnstr00009365
      WBCnstr00009366
      WBCnstr00010813
      WBCnstr00013297
      WBCnstr00013534
      WBCnstr00013842
      WBCnstr00013844
      WBCnstr00013913
      WBCnstr00014565
      WBCnstr00014566
      WBCnstr00014567
      WBCnstr00014617
      WBCnstr00014842
      WBCnstr00014843
      WBCnstr00014844
      WBCnstr00014845
      WBCnstr00014846
      WBCnstr00014847
      WBCnstr00014848
      WBCnstr00014890
      WBCnstr00014923
      WBCnstr00014924
      WBCnstr00014925
      WBCnstr00014926
      WBCnstr00014927
      WBCnstr00014928
      WBCnstr00014929
      WBCnstr00014930
      WBCnstr00015027
      WBCnstr00015844
      WBCnstr00015900
      WBCnstr00015901
      WBCnstr00015902
      WBCnstr00015903
      WBCnstr00015904
      WBCnstr00016253
      WBCnstr00017056
      WBCnstr00017252
      WBCnstr00017376
      WBCnstr00017546
      WBCnstr00017650
      WBCnstr00017651
      WBCnstr00017652
      WBCnstr00017685
      WBCnstr00017892
      WBCnstr00018027
      WBCnstr00018029
      WBCnstr00018037
      WBCnstr00018039
      WBCnstr00018245
      WBCnstr00018248
      WBCnstr00018444
      WBCnstr00018950
      WBCnstr00018951
      WBCnstr00018952
      WBCnstr00018953
      WBCnstr00019143
      WBCnstr00019324
      WBCnstr00019479
      WBCnstr00019779
      WBCnstr00019923
      WBCnstr00019924
      WBCnstr00019930
      WBCnstr00020162
      WBCnstr00020427
      WBCnstr00020480
      WBCnstr00020558
      WBCnstr00020633
      WBCnstr00020634
      WBCnstr00020983
      WBCnstr00021229
      WBCnstr00021653
      WBCnstr00021877
      WBCnstr00022296
      WBCnstr00022581
      WBCnstr00022582
      WBCnstr00022747
      WBCnstr00022884
      WBCnstr00023002
      WBCnstr00023003
      WBCnstr00023051
      WBCnstr00023063
      WBCnstr00023086
      WBCnstr00023087
      WBCnstr00023088
      WBCnstr00023112
      WBCnstr00023154
      WBCnstr00038123
      WBCnstr00038124
      WBCnstr00038125
      WBCnstr00038126
      WBCnstr00038127
      WBCnstr00038389
      WBCnstr00038464
      WBCnstr00038466
      WBCnstr00039109
      WBCnstr00039110
      WBCnstr00039250
      WBCnstr00039308
      WBCnstr00039309
      WBCnstr00039523
      WBCnstr00039989
      WBCnstr00040842
      WBCnstr00040843
      WBCnstr00040856
      WBCnstr00040860
      WBCnstr00040865
      WBCnstr00040870
      WBCnstr00041074
      WBCnstr00041278
      WBCnstr00041501
      WBCnstr00041503
      WBCnstr00041965
      WBCnstr00042080
      WBCnstr00042161
      WBCnstr00042162
      WBCnstr00042163
      WBCnstr00042164
      WBCnstr00042165
      WBCnstr00042166
      WBCnstr00042683
      WBCnstr00042987
      WBCnstr00042992
    Construct_product: WBCnstr00013297
      WBCnstr00016253
      WBCnstr00038389
    Antibody: WBAntibody00000406
    Microarray_results (20)
    Expression_cluster (230)
    Interaction (123)
  Map_info: Map: II Position: 3.46558 Error: 0.000297
    Positive: Positive_clone: VW02B12L Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (28)
  Remark: Sequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr>
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene