WormBase Tree Display for Gene: WBGene00003639
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WBGene00003639 | Evidence | Paper_evidence | WBPaper00003416 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K10C3 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | nhr-49 | Person_evidence | WBPerson600 | |||||
Sequence_name | K10C3.6 | ||||||||
Molecular_name (17) | |||||||||
Other_name | CELE_K10C3.6 | Accession_evidence | NDB | BX284601 | |||||
Public_name | nhr-49 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | nhr | ||||||||
Allele (78) | |||||||||
Strain | WBStrain00031166 | ||||||||
WBStrain00031167 | |||||||||
WBStrain00031172 | |||||||||
WBStrain00032408 | |||||||||
WBStrain00034504 | |||||||||
WBStrain00036136 | |||||||||
WBStrain00040338 | |||||||||
WBStrain00049816 | |||||||||
WBStrain00051874 | |||||||||
WBStrain00052029 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (44) | |||||||||
Contained_in_operon | CEOP1566 | ||||||||
Ortholog (37) | |||||||||
Paralog (42) | |||||||||
Structured_description | Concise_description | nhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts. | Paper_evidence | WBPaper00003416 | |||||
WBPaper00005655 | |||||||||
WBPaper00024532 | |||||||||
WBPaper00025114 | |||||||||
WBPaper00026800 | |||||||||
WBPaper00027365 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Mar 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in determination of adult lifespan; positive regulation of transcription from RNA polymerase II promoter in response to stress; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00025114 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
Potential_model | DOID:0111099 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | |||||
DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:9993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:1686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:0080760 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
Models_disease_asserted | WBDOannot00000610 | ||||||||
WBDOannot00000707 | |||||||||
WBDOannot00000708 | |||||||||
Molecular_info | Corresponding_CDS | K10C3.6a | |||||||
K10C3.6b | |||||||||
K10C3.6c | |||||||||
K10C3.6d | |||||||||
K10C3.6e | |||||||||
Corresponding_transcript | K10C3.6a.1 | ||||||||
K10C3.6a.2 | |||||||||
K10C3.6b.1 | |||||||||
K10C3.6b.2 | |||||||||
K10C3.6c.1 | |||||||||
K10C3.6d.1 | |||||||||
K10C3.6e.1 | |||||||||
Other_sequence (69) | |||||||||
Associated_feature (15) | |||||||||
Transcription_factor | WBTranscriptionFactor000564 | ||||||||
Experimental_info | RNAi_result (49) | ||||||||
Expr_pattern | Expr9486 | ||||||||
Expr10378 | |||||||||
Expr12144 | |||||||||
Expr16231 | |||||||||
Expr1021226 | |||||||||
Expr1031683 | |||||||||
Expr1154213 | |||||||||
Expr2014198 | |||||||||
Expr2032439 | |||||||||
Drives_construct | WBCnstr00015289 | ||||||||
WBCnstr00020172 | |||||||||
WBCnstr00035977 | |||||||||
Construct_product | WBCnstr00014051 | ||||||||
WBCnstr00016239 | |||||||||
WBCnstr00020172 | |||||||||
WBCnstr00021645 | |||||||||
WBCnstr00021647 | |||||||||
WBCnstr00035977 | |||||||||
Regulate_expr_cluster | WBPaper00040134:nhr-49(RNAi)_regulated_protein | ||||||||
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated | |||||||||
WBPaper00061530:nhr-49(e2144)_downregulated | |||||||||
WBPaper00061530:nhr-49(e2144)_upregulated | |||||||||
Microarray_results (39) | |||||||||
Expression_cluster (104) | |||||||||
SAGE_tag (12) | |||||||||
Interaction (374) | |||||||||
WBProcess | WBbiopr:00000001 | ||||||||
WBbiopr:00000121 | |||||||||
Map_info | Map | I | Position | 3.96404 | Error | 0.005389 | |||
Positive | Positive_clone | K10C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 5149 | |||||||
4447 | |||||||||
Pseudo_map_position | |||||||||
Reference (157) | |||||||||
Picture | WBPicture0000013096 | ||||||||
WBPicture0000013097 | |||||||||
WBPicture0000013098 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |