WormBase Tree Display for Gene: WBGene00002992

WBGene00002992 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 2
    Name: CGC_name: lin-3 Person_evidence: WBPerson261
      Sequence_name: F36H1.4
      Molecular_name (27)
      Other_name: let-94
        sli-4 Paper_evidence: WBPaper00028495
          Person_evidence: WBPerson625
        CELE_F36H1.4 Accession_evidence: NDB BX284604
      Public_name: lin-3
    DB_info: Database: AceView gene 4L827
        WormQTL gene WBGene00002992
        SignaLink protein WBGene00002992
        WormFlux gene WBGene00002992
        NDB locus_tag CELE_F36H1.4
        NCBI gene 178001
        RefSeq protein NM_001129305.3
            NM_171418.7
            NM_001307091.3
            NM_001380456.1
            NM_001307092.4
            NM_171918.7
            NM_171919.8
            NM_001380457.2
        SwissProt UniProtAcc Q03345
        TREEFAM TREEFAM_ID TF321602
        TrEMBL UniProtAcc A0A061AEC4
            A0A061AD43
        UniProt_GCRP UniProtAcc Q03345
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Oct 2006 10:39:45 WBPerson2970 Name_change: Other_name: sli-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00143992
    Allele (126)
    Legacy_information: e1417 : adult hermaphrodite vulvaless (penetrance 89%); HME2; adult male wildtype ME2. NA4 (n378 (resembles e1417); n1059 (early larval lethal); n1058 (early larval lethal/sterile adult ME3)).
      See also e1417, n378, n1058, n1059, s751, s1263, s1750
      [C.elegansII] e1417 : adult hermaphrodite vulvaless (penetrance 89%); HME2; adult male wildtype ME2. OA>10: n378 (resembles e1417)d,; n1059 (early larval lethal), n1058 (early larval lethal/sterile adult),s751 (pka let-94, late larval lethal, s751/Df early larval lethal), s1750 (homozygote and hemizygote mid larval lethal), etc. Cloned: encodes proteins with similarity to EGF family. Transgene overexpression leads to Muv(extra vulval differentiation). [Hill and Sternberg 1992; BC; MT; PS]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog (21)
    Structured_description: Concise_description: lin-3 encodes a member of the EGF family of peptide growth factors that affects induction of vulval development, viability, ovulation, behavioral quiescence after stress, and male spicule development; it acts genetically upstream of its presumptive receptor let-23, and is expressed in multiple locations consistent with it acting as a localized ligand; for example, the anchor cell of the developing gonad, which induces vulval development. Paper_evidence: WBPaper00000496
            WBPaper00001573
            WBPaper00045813
            WBPaper00002043
          Person_evidence: WBPerson625
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 13 Jul 2015 00:00:00
      Automated_description: Enables receptor ligand activity. Involved in several processes, including positive regulation of ovulation; positive regulation of vulval development; and reproductive process. Located in plasma membrane. Expressed in several structures, including excretory canal; germ line; hermaphrodite gonad; rectal epithelial cell; and vulF. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F36H1.4a
      F36H1.4b
      F36H1.4c
      F36H1.4d
      F36H1.4e
      F36H1.4f
      F36H1.4g
      F36H1.4h
    Corresponding_CDS_history: F36H1.4:wp52
    Corresponding_transcript (11)
    Other_sequence: CR09820
      CRC07071_1
      CJC02266_1
    Associated_feature (12)
  Experimental_info: RNAi_result (54)
    Expr_pattern (16)
    Drives_construct (19)
    Construct_product (27)
    Microarray_results (44)
    Expression_cluster (158)
    Interaction (299)
    WBProcess: WBbiopr:00000020
      WBbiopr:00000044
      WBbiopr:00000067
      WBbiopr:00000070
      WBbiopr:00000071
  Map_info: Map: IV Position: 4.82027 Error: 0.004649
    Well_ordered
    Positive: Positive_clone: F36H1 Inferred_automatically: From sequence, transcript, pseudogene data
        PS#001
    Mapping_data: 2_point: 3296
      Multi_point: 117
        382
        383
        603
        678
        774
        1135
        1137
        1276
        1640
      Pos_neg_data (16)
  Reference: WBPaper00000496
    WBPaper00000500
    WBPaper00000608
    WBPaper00000762
    WBPaper00000957
    WBPaper00001040
    WBPaper00001185
    WBPaper00001292
    WBPaper00001293
    WBPaper00001356
    WBPaper00001473
    WBPaper00001490
    WBPaper00001522
    WBPaper00001573
    WBPaper00001625
    WBPaper00001657
    WBPaper00001670
    WBPaper00001679
    WBPaper00001719
    WBPaper00001724
    WBPaper00001728
    WBPaper00001736
    WBPaper00001756
    WBPaper00001794
    WBPaper00001795
    WBPaper00001799
    WBPaper00001829
    WBPaper00001857
    WBPaper00001860
    WBPaper00001868
    WBPaper00001869
    WBPaper00001909
    WBPaper00001933
    WBPaper00001945
    WBPaper00001946
    WBPaper00001949
    WBPaper00001959
    WBPaper00001998
    WBPaper00002006
    WBPaper00002009
    WBPaper00002043
    WBPaper00002106
    WBPaper00002138
    WBPaper00002148
    WBPaper00002150
    WBPaper00002151
    WBPaper00002161
    WBPaper00002170
    WBPaper00002211
    WBPaper00002215
    WBPaper00002216
    WBPaper00002219
    WBPaper00002225
    WBPaper00002287
    WBPaper00002345
    WBPaper00002349
    WBPaper00002350
    WBPaper00002366
    WBPaper00002375
    WBPaper00002382
    WBPaper00002412
    WBPaper00002448
    WBPaper00002477
    WBPaper00002498
    WBPaper00002520
    WBPaper00002540
    WBPaper00002552
    WBPaper00002617
    WBPaper00002656
    WBPaper00002727
    WBPaper00002735
    WBPaper00002811
    WBPaper00002893
    WBPaper00002916
    WBPaper00002938
    WBPaper00002963
    WBPaper00003006
    WBPaper00003007
    WBPaper00003017
    WBPaper00003085
    WBPaper00003133
    WBPaper00003135
    WBPaper00003177
    WBPaper00003202
    WBPaper00003203
    WBPaper00003231
    WBPaper00003329
    WBPaper00003330
    WBPaper00003427
    WBPaper00003429
    WBPaper00003618
    WBPaper00003632
    WBPaper00003778
    WBPaper00003822
    WBPaper00003839
    WBPaper00003861
    WBPaper00003878
    WBPaper00003990
    WBPaper00004213
    WBPaper00004224
    WBPaper00004235
    WBPaper00004273
    WBPaper00004293
    WBPaper00004362
    WBPaper00004435
    WBPaper00004463
    WBPaper00004853
    WBPaper00004964
    WBPaper00005046
    WBPaper00005137
    WBPaper00005165
    WBPaper00005198
    WBPaper00005237
    WBPaper00005250
    WBPaper00005268
    WBPaper00005445
    WBPaper00005571
    WBPaper00005669
    WBPaper00005792
    WBPaper00005809
    WBPaper00005965
    WBPaper00005987
    WBPaper00005989
    WBPaper00006035
    WBPaper00006209
    WBPaper00006271
    WBPaper00006284
    WBPaper00006320
    WBPaper00006370
    WBPaper00006450
    WBPaper00006503
    WBPaper00010766
    WBPaper00011001
    WBPaper00011071
    WBPaper00011367
    WBPaper00011764
    WBPaper00011855
    WBPaper00012511
    WBPaper00012575
    WBPaper00012622
    WBPaper00012959
    WBPaper00013412
    WBPaper00013806
    WBPaper00013987
    WBPaper00014177
    WBPaper00014218
    WBPaper00014248
    WBPaper00014284
    WBPaper00014334
    WBPaper00014422
    WBPaper00014515
    WBPaper00014589
    WBPaper00014651
    WBPaper00014705
    WBPaper00014745
    WBPaper00014789
    WBPaper00014830
    WBPaper00014832
    WBPaper00014895
    WBPaper00014900
    WBPaper00014979
    WBPaper00015067
    WBPaper00015108
    WBPaper00015246
    WBPaper00015248
    WBPaper00015250
    WBPaper00015283
    WBPaper00015349
    WBPaper00015440
    WBPaper00015766
    WBPaper00015978
    WBPaper00016932
    WBPaper00016949
    WBPaper00016980
    WBPaper00017105
    WBPaper00017185
    WBPaper00017201
    WBPaper00017222
    WBPaper00017293
    WBPaper00017301
    WBPaper00017326
    WBPaper00017419
    WBPaper00017440
    WBPaper00017446
    WBPaper00017541
    WBPaper00017756
    WBPaper00017757
    WBPaper00017859
    WBPaper00017886
    WBPaper00018092
    WBPaper00018131
    WBPaper00018136
    WBPaper00018138
    WBPaper00018431
    WBPaper00018437
    WBPaper00018851
    WBPaper00018932
    WBPaper00019441
    WBPaper00019465
    WBPaper00020840
    WBPaper00020852
    WBPaper00020916
    WBPaper00020918
    WBPaper00021034
    WBPaper00021051
    WBPaper00021791
    WBPaper00021794
    WBPaper00021804
    WBPaper00021835
    WBPaper00021880
    WBPaper00021892
    WBPaper00021910
    WBPaper00022006
    WBPaper00022017
    WBPaper00022247
    WBPaper00022271
    WBPaper00022332
    WBPaper00022377
    WBPaper00022414
    WBPaper00022416
    WBPaper00022487
    WBPaper00022506
    WBPaper00022532
    WBPaper00022682
    WBPaper00022792
    WBPaper00022807
    WBPaper00022880
    WBPaper00022900
    WBPaper00022904
    WBPaper00023081
    WBPaper00023182
    WBPaper00023259
    WBPaper00023320
    WBPaper00023998
    WBPaper00024001
    WBPaper00024003
    WBPaper00024262
    WBPaper00024307
    WBPaper00024311
    WBPaper00024312
    WBPaper00024876
    WBPaper00024993
    WBPaper00025135
    WBPaper00025322
    WBPaper00025445
    WBPaper00025707
    WBPaper00025938
    WBPaper00026161
    WBPaper00026636
    WBPaper00026850
    WBPaper00026872
    WBPaper00026891
    WBPaper00026937
    WBPaper00027025
    WBPaper00027225
    WBPaper00027237
    WBPaper00027265
    WBPaper00027278
    WBPaper00027309
    WBPaper00027316
    WBPaper00027620
    WBPaper00027626
    WBPaper00027667
    WBPaper00027758
    WBPaper00027888
    WBPaper00027908
    WBPaper00028466
    WBPaper00028495
    WBPaper00028559
    WBPaper00028986
    WBPaper00029013
    WBPaper00029018
    WBPaper00029038
    WBPaper00029054
    WBPaper00029156
    WBPaper00029327
    WBPaper00030459
    WBPaper00030864
    WBPaper00031030
    WBPaper00031110
    WBPaper00031325
    WBPaper00032289
    WBPaper00032452
    WBPaper00032465
    WBPaper00033120
    WBPaper00033459
    WBPaper00034602
    WBPaper00034916
    WBPaper00034925
    WBPaper00035100
    WBPaper00036029
    WBPaper00036312
    WBPaper00036768
    WBPaper00036783
    WBPaper00036795
    WBPaper00036826
    WBPaper00036867
    WBPaper00037016
    WBPaper00037906
    WBPaper00038000
    WBPaper00038447
    WBPaper00038541
    WBPaper00038572
    WBPaper00038606
    WBPaper00038868
    WBPaper00039056
    WBPaper00039128
    WBPaper00039455
    WBPaper00039496
    WBPaper00040292
    WBPaper00040630
    WBPaper00041044
    WBPaper00042358
    WBPaper00042754
    WBPaper00042768
    WBPaper00042933
    WBPaper00043506
    WBPaper00043579
    WBPaper00043612
    WBPaper00043613
    WBPaper00043614
    WBPaper00043660
    WBPaper00043883
    WBPaper00045315
    WBPaper00045607
    WBPaper00045626
    WBPaper00045813
    WBPaper00045882
    WBPaper00046137
    WBPaper00046266
    WBPaper00046662
    WBPaper00046915
    WBPaper00047302
    WBPaper00047652
    WBPaper00047814
    WBPaper00048158
    WBPaper00048305
    WBPaper00048320
    WBPaper00048326
    WBPaper00049661
    WBPaper00050069
    WBPaper00050556
    WBPaper00050812
    WBPaper00051596
    WBPaper00052205
    WBPaper00052269
    WBPaper00052590
    WBPaper00053631
    WBPaper00054917
    WBPaper00055608
    WBPaper00056292
    WBPaper00056648
    WBPaper00056812
    WBPaper00057074
    WBPaper00057892
    WBPaper00059377
    WBPaper00061440
    WBPaper00061916
    WBPaper00064107
    WBPaper00064587
    WBPaper00065116
  Remark: Updated sequence connections to take account of splice variants. [02/03/28 krb]
  Method: Gene