WormBase Tree Display for Gene: WBGene00004774
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WBGene00004774 | SMap | S_parent | Sequence | C14F5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sem-5 | Person_evidence | WBPerson268 | |||||
Sequence_name | C14F5.5 | ||||||||
Molecular_name | C14F5.5 | ||||||||
C14F5.5.1 | |||||||||
CE01784 | |||||||||
Other_name | CELE_C14F5.5 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sem-5 | ||||||||
DB_info | Database | AceView | gene | XI578 | |||||
WormQTL | gene | WBGene00004774 | |||||||
SignaLink | protein | WBGene00004774 | |||||||
WormFlux | gene | WBGene00004774 | |||||||
NDB | locus_tag | CELE_C14F5.5 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004774|UniProtKB=P29355 | |||||||
family | PTHR46037 | ||||||||
NCBI | gene | 181055 | |||||||
RefSeq | protein | NM_076941.9 | |||||||
SwissProt | UniProtAcc | P29355 | |||||||
TREEFAM | TREEFAM_ID | TF354288 | |||||||
UniProt_GCRP | UniProtAcc | P29355 | |||||||
OMIM | gene | 604330 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sem | ||||||||
Allele (51) | |||||||||
Legacy_information | [C.elegansII] n2030 : vulvaless, hermaphrodite sex muscles show subtle positioning defect, Soc (suppressor of clr-1),impenetrant Mel (rod-like larval lethal); pleiotropic effects on migration, vulval induction etc. ME0. OA5: strong alleles n1619, n2019; weaker alleles n1781, n2195 (Soc, weak Egl, ME3),n1619, n1779 (synergizes with alleles of unc-71,unc-73, egl-15, egl-17,to give stronger Sem defect). Cloned: encodes predicted SH3-SH2-SH3 protein with 60% identity to human GRB2, functional equivalence. [Clark et al. 1992; Stern et al. 1993; DeVore et al.1995; MT; NH] | ||||||||
Strain | WBStrain00027118 | ||||||||
WBStrain00027128 | |||||||||
WBStrain00027153 | |||||||||
WBStrain00027194 | |||||||||
WBStrain00027242 | |||||||||
WBStrain00028761 | |||||||||
WBStrain00030723 | |||||||||
WBStrain00035409 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (22) | |||||||||
Contained_in_operon | CEOPX092 | ||||||||
Ortholog (44) | |||||||||
Paralog | WBGene00006410 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
Structured_description | Concise_description | sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355) and Drosophila Drk; sem-5 functions in multiple signaling pathways during development including those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, and IP-3-, mediated signal transduction; a sem-5::yfp promoter fusion is expressed in many cells throughout development, including the hypodermis, intestine, neurons, body wall muscles, and vulval precursor cells. | Paper_evidence | WBPaper00001519 | |||||
WBPaper00005353 | |||||||||
WBPaper00005792 | |||||||||
WBPaper00027119 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 25 Aug 2009 00:00:00 | ||||||||
Automated_description | Enables epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; male genitalia development; and regulation of vulval development. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be part of COP9 signalosome. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114; breast cancer; and reproductive organ cancer (multiple). Is an ortholog of human GRB2 (growth factor receptor bound protein 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4566) | ||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4566) | ||||||
DOID:0111642 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4562) | ||||||
DOID:2526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4566) | ||||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4566) | ||||||
Molecular_info | Corresponding_CDS | C14F5.5 | |||||||
Corresponding_transcript | C14F5.5.1 | ||||||||
Other_sequence (33) | |||||||||
Associated_feature (17) | |||||||||
Experimental_info | RNAi_result (35) | ||||||||
Expr_pattern | Expr3985 | ||||||||
Expr4588 | |||||||||
Expr13649 | |||||||||
Expr1026960 | |||||||||
Expr1032366 | |||||||||
Expr1144621 | |||||||||
Expr2015743 | |||||||||
Expr2033976 | |||||||||
Drives_construct | WBCnstr00011797 | ||||||||
WBCnstr00012097 | |||||||||
WBCnstr00035397 | |||||||||
Construct_product | WBCnstr00035397 | ||||||||
Microarray_results (18) | |||||||||
Expression_cluster (115) | |||||||||
Interaction (368) | |||||||||
WBProcess | WBbiopr:00000071 | ||||||||
Map_info | Map | X | Position | -0.822248 | Error | 0.024961 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | raDf2 | |||||||
raDf6 | |||||||||
raDf7 | |||||||||
raDf9 | |||||||||
Positive_clone | C14F5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point | 4454 | |||||||
Multi_point | 1538 | ||||||||
1539 | |||||||||
1583 | |||||||||
4730 | |||||||||
5256 | |||||||||
Pos_neg_data | 4455 | ||||||||
9428 | |||||||||
9430 | |||||||||
9432 | |||||||||
9435 | |||||||||
Reference (166) | |||||||||
Method | Gene |