[B Bowerman] defects in first cell cycle - pronuclear migration is defective, the mitotic spindle does not form, and cell division fails. (RNAi phenocopies mutant phenotype)
Complementation_data
[B Bowerman] complements let-371(h123) and let-359(h94) and let-361(h97) and let-363(h98) and let-364(h104)
spd-5 encodes a coiled-coil domain protein; spd-5 activity is required for centrosome maturation, symmetry breaking, pronuclear migration, mitotic spindle assembly, and cell division; in regulating centrosome maturation, spd-5 interacts genetically with spd-2, which also encodes a coiled-coil protein; SPD-5 physically interacts with CED-9, a C. elegans BCL2 ortholog and spd-5(RNAi) results in increased germline apoptosis, suggesting an additional role for SPD-5 in regulation of apoptosis; SPD-5 localizes to the pericentriolar material.
Enables identical protein binding activity. Involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle. Located in centrosome and cytoplasm.