WormBase Tree Display for Gene: WBGene00003003
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WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lin-14 | Person_evidence | WBPerson261 | |||||
Sequence_name | T25C12.1 | ||||||||
Molecular_name | T25C12.1a | ||||||||
T25C12.1a.1 | |||||||||
CE43285 | |||||||||
T25C12.1b | |||||||||
CE03734 | |||||||||
T25C12.1b.1 | |||||||||
Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lin-14 | ||||||||
DB_info | Database (9) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lin | ||||||||
Reference_allele | WBVar00089301 | ||||||||
WBVar00089587 | |||||||||
Allele (337) | |||||||||
Legacy_information | Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage. | ||||||||
See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842 | |||||||||
[C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT] | |||||||||
Strain (20) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (16) | |||||||||
Ortholog (28) | |||||||||
Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||||
WBPaper00001137 | |||||||||
WBPaper00001468 | |||||||||
WBPaper00001829 | |||||||||
WBPaper00001848 | |||||||||
WBPaper00003931 | |||||||||
WBPaper00005159 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed (2) | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T25C12.1a | |||||||
T25C12.1b | |||||||||
Corresponding_CDS_history | T25C12.1a:wp196 | ||||||||
Corresponding_transcript | T25C12.1a.1 | ||||||||
T25C12.1b.1 | |||||||||
Other_sequence (11) | |||||||||
Associated_feature | WBsf648548 | ||||||||
WBsf663342 | |||||||||
WBsf663343 | |||||||||
WBsf663344 | |||||||||
WBsf663345 | |||||||||
WBsf663346 | |||||||||
WBsf663347 | |||||||||
WBsf663348 | |||||||||
WBsf663349 | |||||||||
WBsf663350 | |||||||||
WBsf663351 | |||||||||
WBsf663352 | |||||||||
WBsf663353 | |||||||||
WBsf663354 | |||||||||
WBsf663355 | |||||||||
WBsf663356 | |||||||||
WBsf663357 | |||||||||
WBsf663358 | |||||||||
WBsf663359 | |||||||||
WBsf718702 | |||||||||
WBsf982235 | |||||||||
WBsf1007004 | |||||||||
WBsf1007005 | |||||||||
WBsf1007006 | |||||||||
WBsf1007007 | |||||||||
WBsf1007008 | |||||||||
WBsf1007009 | |||||||||
WBsf1007010 | |||||||||
WBsf1007011 | |||||||||
WBsf1007012 | |||||||||
WBsf1007013 | |||||||||
WBsf1007014 | |||||||||
WBsf1007015 | |||||||||
WBsf1007016 | |||||||||
WBsf1007017 | |||||||||
WBsf1007018 | |||||||||
WBsf1007019 | |||||||||
WBsf1007020 | |||||||||
WBsf1007021 | |||||||||
WBsf1007022 | |||||||||
WBsf1007023 | |||||||||
WBsf1023877 | |||||||||
WBsf1023878 | |||||||||
WBsf1023879 | |||||||||
WBsf1023880 | |||||||||
WBsf1023881 | |||||||||
WBsf1023882 | |||||||||
WBsf1023883 | |||||||||
WBsf1023884 | |||||||||
WBsf1023885 | |||||||||
WBsf1023886 | |||||||||
WBsf1023887 | |||||||||
WBsf1023888 | |||||||||
WBsf236380 | |||||||||
WBsf919695 | |||||||||
Transcription_factor | WBTranscriptionFactor000395 | ||||||||
Experimental_info (10) | |||||||||
Map_info | Map | X | Position | 3.78431 | Error | 0.060767 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf19 | |||||||
yDp8 | |||||||||
yDp10 | |||||||||
Positive_clone | PPE4 | ||||||||
T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 251 | |||||||
492 | |||||||||
636 | |||||||||
637 | |||||||||
688 | |||||||||
3648 | |||||||||
3652 | |||||||||
Multi_point (22) | |||||||||
Pos_neg_data | 3918 | ||||||||
3920 | |||||||||
654 | |||||||||
668 | |||||||||
3155 | |||||||||
294 | |||||||||
1831 | |||||||||
8427 | |||||||||
Reference (365) | |||||||||
Method | Gene |