WormBase Tree Display for Gene: WBGene00002978
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| WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lev-11 | Person_evidence | WBPerson368 | |||||
| Sequence_name | Y105E8B.1 | ||||||||
| Molecular_name (58) | |||||||||
| Other_name | tmy-1 | ||||||||
| Y105E8B.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CeTM | Paper_evidence | WBPaper00005168 | |||||||
| WBPaper00032338 | |||||||||
| CELE_Y105E8B.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lev-11 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lev | ||||||||
| Reference_allele | WBVar00275207 | ||||||||
| Allele (206) | |||||||||
| Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | ||||||||
| See also e1724 | |||||||||
| [Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | |||||||||
| [C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | |||||||||
| [C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | |||||||||
| Strain | WBStrain00002959 | ||||||||
| WBStrain00033515 | |||||||||
| WBStrain00033518 | |||||||||
| WBStrain00033524 | |||||||||
| WBStrain00040917 | |||||||||
| WBStrain00040918 | |||||||||
| WBStrain00004923 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | |||||
| WBPaper00004944 | |||||||||
| Curator_confirmed (3) | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed (2) | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||
| DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||||
| DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | ||||||
| Molecular_info | Corresponding_CDS (19) | ||||||||
| Corresponding_CDS_history | Y105E8B.1b:wp62 | ||||||||
| Y105E8B.1b:wp114 | |||||||||
| Y105E8B.1c:wp62 | |||||||||
| Corresponding_transcript (20) | |||||||||
| Other_sequence (913) | |||||||||
| Associated_feature | WBsf028058 | ||||||||
| WBsf028059 | |||||||||
| WBsf028060 | |||||||||
| WBsf028061 | |||||||||
| WBsf649767 | |||||||||
| WBsf649768 | |||||||||
| WBsf663842 | |||||||||
| WBsf663843 | |||||||||
| WBsf663844 | |||||||||
| WBsf665140 | |||||||||
| WBsf665141 | |||||||||
| WBsf665142 | |||||||||
| WBsf665143 | |||||||||
| WBsf665144 | |||||||||
| WBsf665145 | |||||||||
| WBsf665146 | |||||||||
| WBsf665147 | |||||||||
| WBsf717606 | |||||||||
| WBsf986195 | |||||||||
| WBsf986196 | |||||||||
| WBsf986197 | |||||||||
| WBsf986198 | |||||||||
| WBsf986199 | |||||||||
| WBsf986200 | |||||||||
| WBsf986201 | |||||||||
| WBsf986202 | |||||||||
| WBsf1011272 | |||||||||
| WBsf1011273 | |||||||||
| WBsf1011274 | |||||||||
| WBsf1011275 | |||||||||
| WBsf1011276 | |||||||||
| WBsf220628 | |||||||||
| WBsf220629 | |||||||||
| WBsf220630 | |||||||||
| WBsf220631 | |||||||||
| Experimental_info | RNAi_result (31) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00010369 | ||||||||
| WBCnstr00012505 | |||||||||
| WBCnstr00016244 | |||||||||
| WBCnstr00041176 | |||||||||
| Antibody | WBAntibody00000099 | ||||||||
| WBAntibody00000422 | |||||||||
| WBAntibody00000423 | |||||||||
| WBAntibody00000472 | |||||||||
| Microarray_results | 171997_x_at | ||||||||
| 172001_x_at | |||||||||
| 175734_s_at | |||||||||
| 176396_s_at | |||||||||
| 176425_s_at | |||||||||
| 194257_x_at | |||||||||
| A_12_P105752 | |||||||||
| A_12_P133935 | |||||||||
| A_12_P141215 | |||||||||
| A_12_P146035 | |||||||||
| A_12_P155145 | |||||||||
| GPL13394_WBGene00002978 | |||||||||
| GPL13914_Y105E8B.1 | |||||||||
| GPL14144_Y105E8B.1a_436-495_0.632_31_C | |||||||||
| GPL14144_Y105E8B.1a_621-680_0.688_23_A | |||||||||
| GPL14144_Y105E8B.1a_807-866_0.822_8_B | |||||||||
| GPL19516_CGZ0041917 | |||||||||
| GPL19516_CGZ0041918 | |||||||||
| GPL19516_CGZ0041919 | |||||||||
| GPL19516_CGZ0041920 | |||||||||
| GPL19516_CGZ0041921 | |||||||||
| GPL19516_CGZ0041922 | |||||||||
| GPL19516_CGZ0041923 | |||||||||
| GPL19516_CGZ0041924 | |||||||||
| GPL19516_CGZ0041925 | |||||||||
| GPL19516_CGZ0041926 | |||||||||
| GPL19516_CGZ0041927 | |||||||||
| GPL21109_Y105E8B.1a | |||||||||
| GPL3518_CE28782 | |||||||||
| GPL3518_CE29059 | |||||||||
| GPL3518_CE29060 | |||||||||
| GPL3518_CE31733 | |||||||||
| GPL8304_CE_WBGene00002978_A | |||||||||
| GPL8673_Y105E8B_1aP00332 | |||||||||
| GPL8673_Y105E8B_1aP00756 | |||||||||
| GPL8673_Y105E8B_1aP00760 | |||||||||
| GPL8673_Y105E8B_1bP00059 | |||||||||
| GPL8673_Y105E8B_1bP00132 | |||||||||
| GPL8673_Y105E8B_1bP00395 | |||||||||
| GPL8673_Y105E8B_1cP00290 | |||||||||
| GPL8673_Y105E8B_1cP00319 | |||||||||
| GPL8673_Y105E8B_1cP00335 | |||||||||
| GPL8673_Y105E8B_1dP00333 | |||||||||
| GPL8673_Y105E8B_1dP00405 | |||||||||
| GPL8673_Y105E8B_1dP00665 | |||||||||
| GPL8673_Y105E8B_1eP00277 | |||||||||
| GPL8673_Y105E8B_1eP00335 | |||||||||
| GPL8673_Y105E8B_1eP00676 | |||||||||
| GPL8673_Y105E8B_1fP00117 | |||||||||
| GPL8673_Y105E8B_1fP00231 | |||||||||
| GPL8673_Y105E8B_1fP00235 | |||||||||
| GPL9450_Y105E8B.1b | |||||||||
| GPL9450_Y105E8B.1c | |||||||||
| GPL9450_Y105E8B.1d | |||||||||
| GPL9450_Y105E8B.1e | |||||||||
| cea2.3.26990 | |||||||||
| cea2.3.27003 | |||||||||
| cea2.d.06422 | |||||||||
| cea2.d.41975 | |||||||||
| cea2.d.41991 | |||||||||
| cea2.d.42009 | |||||||||
| Expression_cluster (304) | |||||||||
| Interaction (175) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 209 | |||||||
| 213 | |||||||||
| 214 | |||||||||
| 327 | |||||||||
| 5106 | |||||||||
| 6076 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data (13) | |||||||||
| Reference (90) | |||||||||
| Remark | Data extracted from Williams & Waterston 1994 | ||||||||
| The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||||
| Method | Gene |
