WormBase Tree Display for Gene: WBGene00011480

WBGene00011480 SMap: S_parent: Sequence: T05E11
  Identity: Version: 2
    Name: CGC_name: enpl-1 Person_evidence: WBPerson304
      Sequence_name: T05E11.3
      Molecular_name: T05E11.3a
        T05E11.3a.1
        CE06362
        T05E11.3b
        CE45764
        T05E11.3a.2
        T05E11.3b.1
      Other_name: CELE_T05E11.3 Accession_evidence: NDB BX284604
      Public_name: enpl-1
    DB_info: Database: AceView gene 4L887
        WormQTL gene WBGene00011480
        WormFlux gene WBGene00011480
        NDB locus_tag CELE_T05E11.3
        Panther gene CAEEL|WormBase=WBGene00011480|UniProtKB=Q22235
          family PTHR11528
        NCBI gene 178014
        RefSeq protein NM_001268607.4
            NM_001268608.3
        SwissProt UniProtAcc Q22235
        TREEFAM TREEFAM_ID TF105969
        UniProt_GCRP UniProtAcc Q22235
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 31 Aug 2012 11:56:39 WBPerson2970 Name_change: CGC_name: enpl-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: enpl
    Allele (44)
    Possibly_affected_by: WBVar02153291
    Strain: WBStrain00037295
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (38)
    Paralog: WBGene00000915 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020110 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: enpl-1 encodes the C. elegans ortholog of the Hsp90 family member and endoplasmic reticulum (ER) chaperone GRP94/GP96; loss of enpl-1 activity via RNAi results in slow growth, larval arrest, uncoordinated locomotion, and weak endocytosis defects; in addition, loss of enpl-1 expression results in an increase in hsp-4 expression, revealing compensatory regulation amongst ER chaperones; an enpl-1::gfp reporter fusion is expressed in the pharynx, with large-scale expression studies reporting additional expression in the intestine and several unidentified cells in the head. Paper_evidence: WBPaper00003992
            WBPaper00005654
            WBPaper00006395
            WBPaper00025054
            WBPaper00025202
            WBPaper00030951
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Oct 2013 00:00:00
      Automated_description: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Expressed in head; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in lung adenocarcinoma. Is an ortholog of human HSP90B1 (heat shock protein 90 beta family member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12028)
  Molecular_info: Corresponding_CDS: T05E11.3a
      T05E11.3b
    Corresponding_transcript: T05E11.3a.1
      T05E11.3a.2
      T05E11.3b.1
    Other_sequence (237)
    Associated_feature: WBsf646353
      WBsf660677
      WBsf660678
      WBsf660679
      WBsf660680
      WBsf660681
      WBsf660682
      WBsf660683
      WBsf997769
      WBsf1018174
      WBsf229097
  Experimental_info: RNAi_result (14)
    Expr_pattern: Chronogram787
      Expr1791
      Expr6617
      Expr15278
      Expr15293
      Expr1021911
      Expr1035052
      Expr1156136
      Expr2011320
      Expr2029556
    Drives_construct: WBCnstr00002272
      WBCnstr00010447
      WBCnstr00030622
    Construct_product: WBCnstr00030622
    Microarray_results (29)
    Expression_cluster: WBPaper00005700:secreted_protein
      WBPaper00024505:pharyngeal_enriched
      WBPaper00029359_1280
      WBPaper00029359_1310
      WBPaper00029359_1362
      WBPaper00029359_1364
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1578
      WBPaper00029359_1587
      WBPaper00029359_1604
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00035963:S.aureus_4h_downregulated
      WBPaper00035963:S.aureus_8h_downregulated
      WBPaper00035963:S.aureus_24h_downregulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00040965:top50_lipid-droplet_associated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044027:tyrosol_regulated
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00052987:UV_downregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056900:PID-3_interacting
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059373:stt-3(RNAi)_upregulated
      WBPaper00059440:GLP-1_represseded
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059605:MUT-16_interacting
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:g1A_g1P
      WBPaper00061340:g1A_parent
      WBPaper00061340:g2
      WBPaper00061340:g2_parent
      WBPaper00061340:I1_parent
      WBPaper00061340:M1_parent
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:NSM_parent
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:sec-24.1_3187-F07F6.4
      WBPaper00061527:uggt-1_21889-tag-320_20312
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AVB_enriched
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061818:AFD_enriched_protein
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:CAMT-1_interacting
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064201:SNA-1_interacting
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065623:144
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_oocyte_depleted
      cgc4386_cluster_4_4
      cgc4489_group_8
      WBPaper00025032:cluster_193
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_A
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031850:mdt-15(RNAi)_upregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:FedUp
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_H
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q200_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_C
    Interaction (222)
  Map_info: Map: IV Position: 4.89065
    Positive: Positive_clone: T05E11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene