WBGene00001077 | SMap | S_parent | Sequence | CHROMOSOME_III |
| Identity | Version | 1 |
| | Name | CGC_name | dpy-18 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y47D3B.10 |
| | | Molecular_name | Y47D3B.10 |
| | | | Y47D3B.10.1 |
| | | | CE20261 |
| | | Other_name | phy-1 |
| | | | T28D6.1 | Paper_evidence | WBPaper00005747 |
| | | | CELE_Y47D3B.10 | Accession_evidence | NDB | BX284603 |
| | | Public_name | dpy-18 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dpy |
| | Reference_allele | WBVar00143150 |
| | Allele (101) |
| | Possibly_affected_by | WBVar02158838 |
| | Legacy_information | e364amber : medium dumpy. ES3 (adult) ES2 (larvae). ME2. NA3 (e499 e1270). |
| | | See also e1862 |
| | | [C.elegansII] e364amb : medium dumpy. ES3 (adult) ES2 (larvae). ME2. Males have abnormal lumpy rays (Ram) at 25C. OA>10: e499, e1270, e1862,s361fdi, s1304 (induced on eT1), bx26 (Ram at 25C), h662. [Brenner 1974; Baird and Emmons 1990; PB] |
| | Strain (219) |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (60) |
| | Paralog | WBGene00015773 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00004026 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00012815 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00004025 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00077688 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | dpy-18 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (I) isoform (OMIM: 176710), an alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; dpy-18 has a critical role in hydroxylation of cuticle collagens during collagen synthesis; dpy-18, in complex with phy-2, is essential for the survival of the C. elegans; dpy-18 mutations alone result in a mild dumpy phenotype; expressed dpy-18 and ten-1 act in parallel influencing the connection between epidermis and muscle during embryonic development; deletion of dpy-18 causes aggregation of collagen IV in body wall muscles in elongated embryos and triggers the loss of tissue integrity in ten-1 mutants; dpy-18 is expressed throughout the hypodermis, head and posterior neurons. | Paper_evidence | WBPaper00004203 |
| | | | | | WBPaper00031524 |
| | | | | | WBPaper00039988 |
| | | | | Curator_confirmed | WBPerson12884 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 18 Aug 2011 00:00:00 |
| | | Automated_description | Enables procollagen-proline 4-dioxygenase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; embryo development; and embryonic body morphogenesis. Located in endoplasmic reticulum. Expressed in hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in myopia. Is an ortholog of human P4HA1 (prolyl 4-hydroxylase subunit alpha 1) and P4HA2 (prolyl 4-hydroxylase subunit alpha 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:11830 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8547) |
| Molecular_info | Corresponding_CDS | Y47D3B.10 |
| | Corresponding_transcript | Y47D3B.10.1 |
| | Other_sequence (83) |
| | Associated_feature | WBsf667443 |
| | | WBsf994363 |
| | | WBsf994364 |
| | | WBsf994365 |
| | | WBsf994366 |
| | | WBsf994367 |
| | | WBsf1015986 |
| | | WBsf1015987 |
| | | WBsf1015988 |
| | | WBsf227570 |
| | | WBsf227571 |
| Experimental_info | RNAi_result | WBRNAi00056767 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115627 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027622 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00026722 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00094817 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065822 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00094816 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009344 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00019394 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1085 |
| | | Expr1928 |
| | | Expr1931 |
| | | Expr12145 |
| | | Expr1012505 |
| | | Expr1030685 |
| | | Expr1160222 |
| | | Expr1200375 |
| | | Expr2011060 |
| | | Expr2029297 |
| | Drives_construct | WBCnstr00008961 |
| | | WBCnstr00010073 |
| | | WBCnstr00010524 |
| | | WBCnstr00020362 |
| | | WBCnstr00037095 |
| | Construct_product | WBCnstr00008961 |
| | | WBCnstr00008962 |
| | | WBCnstr00008963 |
| | | WBCnstr00010073 |
| | | WBCnstr00037095 |
| | Antibody | WBAntibody00000539 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00028451:Oogenic_protein |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:Cluster_6 |
| | | WBPaper00031097:unc-95(su33)_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00035963:S.aureus_8h_downregulated |
| | | WBPaper00035963:S.aureus_24h_downregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_embryo_enriched |
| | | WBPaper00037950:hypodermis_embryo_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045971:tunicamycin_upregulated_control |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated |
| | | WBPaper00046337:polysomal_N2_vs_daf-2_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_downregulated_protein |
| | | WBPaper00046499:AMPK_regulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048785:heat-shock_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049098:heat-induced_hrde-1(tm1200) |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050686:glp-1(e2141)_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054872:egl-9(sa307)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055897:heat-shock_upregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056039:efa-6(tm3124)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056330:glycine_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058801:ceh-60(lst466)_upregulated_protein |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059373:stt-3(RNAi)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059604:fluvastatin_downregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060273:vrk-1(RNAi)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-extract_1h_regulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:T |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:K10C9.3_8160-Y39G8B.1_58 |
| | | WBPaper00061527:T24C12.3-C01G10.9 |
| | | WBPaper00061527:uggt-1_21889-tag-320_20312 |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00062118:neural-HSF-1_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00062456:doxycycline_upregulated_N2_transcript |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064080:miR-58_miRNA_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064952:Day1_vs_L4_downregulated_25C |
| | | WBPaper00064952:Day5_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day5_vs_L4_downregulated_25C |
| | | WBPaper00064952:Day10_vs_Day1_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_25C |
| | | WBPaper00065074:glna(-)_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_4_6 |
| | | cgc4489_group_8 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00006465:II_ethanol_late_induction |
| | | WBPaper00025032:cluster_71 |
| | | WBPaper00025032:cluster_141 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_A |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:A_to_C_transit_increased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00038172:tax-6null_down_regulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040963:Q50_up |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041207:CE_dauer_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00046083:pmk-1(km25)_OP50_downregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc5376]:let-60(G12V)-regulated_genes |
| | | [cgc5767]:cluster_60 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_C |
| | Interaction (111) |
| | WBProcess | WBbiopr:00000124 |
| Map_info | Map | III | Position | 8.85117 | Error | 0.054776 |
| | Well_ordered |
| | Positive | Inside_rearr | tDp1 |
| | | | mT1 |
| | | Positive_clone | Y47D3B | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point (58) |
| | | Multi_point (145) |
| | | Pos_neg_data (11) |
| | Landmark_gene |
| Reference (127) |
| Method | Gene |