WormBase Tree Display for Gene: WBGene00004025
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| WBGene00004025 | SMap | S_parent | Sequence | F35G2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | phy-2 | Person_evidence | WBPerson466 | |||||
| Sequence_name | F35G2.4 | ||||||||
| Molecular_name | F35G2.4 | ||||||||
| F35G2.4.1 | |||||||||
| CE05811 | |||||||||
| Other_name | CELE_F35G2.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | phy-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | phy | ||||||||
| Allele (93) | |||||||||
| Strain | WBStrain00002845 | ||||||||
| WBStrain00022588 | |||||||||
| WBStrain00031639 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00001077 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004026 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012815 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015773 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00077688 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | phy-2 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (II) isoform (OMIM: 600608); phy-2 is responsible for hydroxylation of cuticle collagen; loss-of-function mutations result in phenotypically wild-type animals, however phy-1; phy-2 double mutants arrest as embryos and larvae, suggesting that the PHY-1 and PHY-2 P2H alpha subunits function redundantly during development; phy-2 in complex with phy-1 is essential for the survival of the C. elegans; PHY-2, are expressed in the cuticle collagen-synthesizing hypodermal cells in a cyclical fashion that corresponds the moulting cycle and the times of maximal cuticle collagen synthesis; phy-2 is also expressed excretory cell, and spermatheca. | Paper_evidence | WBPaper00004203 | |||||
| WBPaper00031524 | |||||||||
| WBPaper00039988 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 18 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables peptidyl-proline 4-dioxygenase activity. Involved in macromolecule modification and obsolete oxidation-reduction process. Located in endoplasmic reticulum. Expressed in excretory cell; hypodermis; and spermatheca. Human ortholog(s) of this gene implicated in myopia. Is an ortholog of human P4HA1 (prolyl 4-hydroxylase subunit alpha 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11830 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8547) | ||||
| Molecular_info | Corresponding_CDS | F35G2.4 | |||||||
| Corresponding_transcript | F35G2.4.1 | ||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf652283 | ||||||||
| WBsf668401 | |||||||||
| WBsf668402 | |||||||||
| WBsf668403 | |||||||||
| WBsf668404 | |||||||||
| WBsf998059 | |||||||||
| WBsf998060 | |||||||||
| WBsf1018342 | |||||||||
| WBsf230982 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00098167 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00090781 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115626 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014372 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002076 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046413 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram943 | ||||||||
| Expr1929 | |||||||||
| Expr1932 | |||||||||
| Expr3473 | |||||||||
| Expr1025120 | |||||||||
| Expr1031927 | |||||||||
| Expr1150278 | |||||||||
| Expr2014914 | |||||||||
| Expr2033150 | |||||||||
| Drives_construct | WBCnstr00003367 | ||||||||
| WBCnstr00010525 | |||||||||
| WBCnstr00011410 | |||||||||
| WBCnstr00035736 | |||||||||
| Construct_product | WBCnstr00035736 | ||||||||
| Antibody | WBAntibody00000541 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (246) | |||||||||
| Interaction (23) | |||||||||
| WBProcess | WBbiopr:00000124 | ||||||||
| Map_info | Map | IV | Position | 5.80229 | Error | 0.00735 | |||
| Positive | Positive_clone | F35G2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4583 | |||||||
| 5280 | |||||||||
| 5302 | |||||||||
| 5519 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
