WormBase Tree Display for Gene: WBGene00008239
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WBGene00008239 | SMap | S_parent | Sequence | C50H2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fshr | ||||||
Allele | WBVar01039424 | ||||||
WBVar01039425 | |||||||
WBVar01742870 | |||||||
WBVar01039426 | |||||||
WBVar01742871 | |||||||
WBVar01039427 | |||||||
WBVar01039428 | |||||||
WBVar01039429 | |||||||
WBVar01039430 | |||||||
WBVar01039431 | |||||||
WBVar01039432 | |||||||
WBVar01039433 | |||||||
WBVar01039434 | |||||||
WBVar01039435 | |||||||
WBVar01500097 | |||||||
WBVar01039436 | |||||||
WBVar01039437 | |||||||
WBVar01039438 | |||||||
WBVar01039439 | |||||||
WBVar01039440 | |||||||
WBVar01039441 | |||||||
WBVar01039442 | |||||||
WBVar01039443 | |||||||
WBVar01039444 | |||||||
WBVar01039445 | |||||||
WBVar01039446 | |||||||
WBVar01039447 | |||||||
WBVar01039448 | |||||||
WBVar00467527 | |||||||
WBVar01039449 | |||||||
WBVar00467528 | |||||||
WBVar01039450 | |||||||
WBVar00467529 | |||||||
WBVar01039451 | |||||||
WBVar00467530 | |||||||
WBVar01039452 | |||||||
WBVar00467531 | |||||||
WBVar01039453 | |||||||
WBVar01039454 | |||||||
WBVar00467532 | |||||||
WBVar01039455 | |||||||
WBVar00467533 | |||||||
WBVar01039456 | |||||||
WBVar00467534 | |||||||
WBVar01039457 | |||||||
WBVar00467535 | |||||||
WBVar01500129 | |||||||
WBVar00252525 | |||||||
WBVar00240805 | |||||||
WBVar02079256 | |||||||
WBVar01899473 | |||||||
WBVar00092058 | |||||||
WBVar01499056 | |||||||
WBVar01500167 | |||||||
WBVar00240277 | |||||||
WBVar00240297 | |||||||
WBVar01863904 | |||||||
WBVar01863905 | |||||||
WBVar01863906 | |||||||
WBVar01863907 | |||||||
WBVar01863908 | |||||||
WBVar01863909 | |||||||
WBVar01499316 | |||||||
WBVar01499510 | |||||||
WBVar01499511 | |||||||
Strain | WBStrain00031623 | ||||||
WBStrain00007212 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (51) | |||||||
Paralog | WBGene00011454 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | fshr-1 encodes a putative neuropeptide receptor required for normalacetylcholine secretion by synapses; FSHR-1 is orthologous to humanfollicle-stimulating hormone receptor (OMIM:136435; mutated in ovariandysgenesis), thyrotropin receptor (OMIM:603372; mutated inhyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutatedin precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1puncta at synapses, suggesting exocytotic defects; the requirement forFSHR-1 and ten other predicted neuropeptide signalling proteins incholinergic neurotransmission indicates that such signalling isimportant for regulating acetylcholine release at neuromuscularjunctions; possible ligands of FSHR-1 are FLP-1 and NLP-12. | Paper_evidence | WBPaper00026667 | |||
Curator_confirmed | WBPerson1823 | ||||||
WBPerson567 | |||||||
Date_last_updated | 09 Nov 2006 00:00:00 | ||||||
Automated_description | Predicted to enable G protein-coupled peptide receptor activity. Involved in defense response to other organism; response to oxidative stress; and stress response to cadmium ion. Predicted to be located in plasma membrane. Expressed in intestine; neurons; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in several diseases, including cystadenocarcinoma (multiple); disorder of sexual development (multiple); and sex cord-gonadal stromal tumor (multiple). Is an ortholog of human FSHR (follicle stimulating hormone receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (16) | ||||||
Molecular_info | Corresponding_CDS | C50H2.1a | |||||
C50H2.1b | |||||||
Corresponding_CDS_history | C50H2.1:wp52 | ||||||
Corresponding_transcript | C50H2.1a.1 | ||||||
C50H2.1b.1 | |||||||
Other_sequence | JI171853.1 | ||||||
Tcol_isotig10998 | |||||||
JI473293.1 | |||||||
CJC04547_1 | |||||||
Tcol_isotig10997 | |||||||
JI468453.1 | |||||||
Associated_feature (5) | |||||||
Experimental_info | RNAi_result (12) | ||||||
Expr_pattern | Expr3541 | ||||||
Expr4567 | |||||||
Expr7940 | |||||||
Expr16472 | |||||||
Expr1012556 | |||||||
Expr1033582 | |||||||
Expr1146942 | |||||||
Expr2011911 | |||||||
Expr2030148 | |||||||
Drives_construct | WBCnstr00006333 | ||||||
WBCnstr00007211 | |||||||
WBCnstr00007212 | |||||||
WBCnstr00007213 | |||||||
WBCnstr00011465 | |||||||
WBCnstr00013014 | |||||||
WBCnstr00033124 | |||||||
WBCnstr00043063 | |||||||
Construct_product | WBCnstr00006333 | ||||||
WBCnstr00007211 | |||||||
WBCnstr00007212 | |||||||
WBCnstr00007213 | |||||||
WBCnstr00020873 | |||||||
WBCnstr00033124 | |||||||
WBCnstr00041283 | |||||||
WBCnstr00041284 | |||||||
WBCnstr00041285 | |||||||
WBCnstr00043063 | |||||||
Regulate_expr_cluster | WBPaper00048530:fshr-1(ok778)_PA14_upregulated | ||||||
WBPaper00048530:fshr-1(ok778)_upregulated | |||||||
Microarray_results (22) | |||||||
Expression_cluster (125) | |||||||
Interaction (38) | |||||||
WBProcess | WBbiopr:00000039 | ||||||
Map_info | Map | V | Position | 2.20466 | Error | 0.001111 | |
Positive | Positive_clone | C50H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5520 | |||||
5436 | |||||||
Pseudo_map_position | |||||||
Reference (45) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |