WormBase Tree Display for Variation: WBVar00092058

WBVar00092058 Name: Public_name: ok778
    Other_name: C50H2.1b.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG
      C50H2.1a.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG
    HGVSg: CHROMOSOME_V:g.9890318_9893541delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG
  Sequence_details: SMap: S_parent: Sequence: C50H2
    Flanking_sequences: caaaaattggatttaatttccaattatagt aactgatttgatttgctggtttccaaccct
    Mapping_target: C50H2
    Type_of_mutation: Insertion: GGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG
      Deletion
    PCR_product: ok778_external
      ok778_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00007212
      WBStrain00031623
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00008239
      WBGene00014712
    Transcript: C50H2.1b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: C50H2.1b.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG
        cDNA_position: ?-2054
        CDS_position: ?-1931
        Protein_position: ?-644
        Intron_number: 2-11/14
        Exon_number: 3-12/15
      C50H2.1a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: C50H2.1a.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG
        cDNA_position: ?-2052
        CDS_position: ?-1931
        Protein_position: ?-644
        Intron_number: 2-11/14
        Exon_number: 3-12/15
      C50H2.9 VEP_consequence: transcript_ablation
        VEP_impact: HIGH
        Exon_number: 1/1
    Interactor: WBInteraction000050841
      WBInteraction000050842
      WBInteraction000503896
      WBInteraction000503897
      WBInteraction000503898
      WBInteraction000503899
      WBInteraction000534831
      WBInteraction000536172
  Isolation: Mutagen: UV/TMP
  Genetics: Mapping_data: In_multi_point: 5520
  Description: Phenotype: WBPhenotype:0000460 Paper_evidence: WBPaper00055106
        Curator_confirmed: WBPerson712
        Remark: An even larger decrease in body bends, from 172.5 to 140.8 body bends/minute, a decrease of 29.2% (p = < 0.0000001) was observed for fshr-1 mutants compared to wild type animals under oxidative stress conditions (Figure 1B). Paper_evidence: WBPaper00055106
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00002747 Paper_evidence: WBPaper00055106
              Curator_confirmed: WBPerson712
      WBPhenotype:0001013 Paper_evidence: WBPaper00032885
        Curator_confirmed: WBPerson495
      WBPhenotype:0001620 Paper_evidence: WBPaper00048530
        Curator_confirmed: WBPerson495
        Remark: fshr-1(ok778) mutants are sensitive to oxidative stress Paper_evidence: WBPaper00048530
            Curator_confirmed: WBPerson495
      WBPhenotype:0002378 Paper_evidence: WBPaper00048530
        Curator_confirmed: WBPerson495
        Remark: fshr-1(ok778) mutants are impaired in their ability to avoid PA14 Paper_evidence: WBPaper00048530
            Curator_confirmed: WBPerson495
    Phenotype_not_observed: WBPhenotype:0000114 Paper_evidence: WBPaper00035891
        Curator_confirmed: WBPerson2987
        Remark: "We also tested the role of several other pathways implicated in C. elegans immunity, including the TGF-beta pathway, JNK pathway, the G protein-coupled receptor fshr-1, and the betacatenin homolog bar-1. None of the pathways we tested appeared to be required for induction of irg-1 (see SI Text and Fig S1)." Paper_evidence: WBPaper00035891
            Curator_confirmed: WBPerson2987
  Reference: WBPaper00035891
    WBPaper00032885
    WBPaper00048530
    WBPaper00055106
    WBPaper00065640
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele