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WormBase Tree Display for Gene: WBGene00007054

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Name Class

WBGene00007054SMapS_parentSequenceB0379
IdentityVersion3
NameCGC_namescpl-1Person_evidenceWBPerson56
Sequence_nameB0379.4
Molecular_name (9)
Other_nametag-188Person_evidenceWBPerson201
CELE_B0379.4Accession_evidenceNDBBX284601
Public_namescpl-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 13:09:06WBPerson1845EventCreated
205 Oct 2005 17:16:53WBPerson2970EventAcquires_mergeWBGene00007157
Name_changeSequence_nameB0379.4
302 Feb 2007 10:26:41WBPerson2970Name_changeCGC_namescpl-1
Other_nametag-188
Acquires_mergeWBGene00007157
WBGene00043085
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classscpl
AlleleWBVar00092349Inferred_automaticallyFrom strain object: RB1101
WBVar00145690Inferred_automaticallyFrom strain object: VC612
WBVar00664812
WBVar00664813
WBVar00664814
WBVar00664815
WBVar00664816
WBVar00307525
WBVar00664817
WBVar00664818
WBVar00664819
WBVar00664820
WBVar00664821
WBVar00664822
WBVar00317683
WBVar00664823
WBVar00214449
WBVar00664824
WBVar00343298
WBVar00214454
WBVar00343299
WBVar00343300
WBVar00343301
WBVar00242833
WBVar01475980
WBVar01475981
WBVar00343302
WBVar01475982
WBVar00343303
WBVar01475983
WBVar00343304
WBVar00343305
WBVar01422900
WBVar00343306
WBVar00343307
WBVar00343308
WBVar00343309
WBVar00343310
WBVar00343311
WBVar00343312
WBVar00343313
WBVar00343314
WBVar00343315
WBVar00343316
WBVar00343317
WBVar00343318
WBVar00343319
WBVar00343320
WBVar00343321
WBVar00343322
WBVar01499739
WBVar00343323
WBVar00343324
WBVar00343325
WBVar00343326
WBVar00343327
WBVar00343328
WBVar00321383
WBVar00156385
WBVar00156386
WBVar00156387
WBVar00156388
WBVar00156389
WBVar00156390
WBVar02148095
WBVar00156391
WBVar00100448
WBVar02016369
WBVar01432682
WBVar01432686
WBVar01391990
WBVar00299414
WBVar01499786
WBVar01499054
WBVar01411687
WBVar01826426
WBVar00664726
WBVar00664727
WBVar00664728
WBVar00664729
WBVar00664730
WBVar00664731
WBVar00664732
WBVar00664733
WBVar00664734
WBVar00664735
WBVar02006270
WBVar00664736
WBVar00664737
WBVar01713026
WBVar01713027
WBVar00664738
WBVar00664739
WBVar00664740
WBVar00664741
WBVar00664742
WBVar00664743
WBVar00664744
WBVar00664745
WBVar00664746
WBVar00664747
WBVar00664748
WBVar00664749
WBVar00664750
WBVar00664751
WBVar00664752
WBVar00664753
WBVar00664754
WBVar00664755
WBVar00664756
WBVar00664757
WBVar00664758
WBVar02073718
WBVar00664759
WBVar00664760
WBVar00664761
WBVar00664762
WBVar00664763
WBVar00664764
WBVar00664765
WBVar00233895
WBVar00664766
WBVar00664767
WBVar00664768
WBVar00664769
WBVar00664770
WBVar00664771
WBVar00664772
WBVar00664773
WBVar01492116
WBVar00664774
WBVar00319554
WBVar00664775
WBVar00664776
WBVar00301607
WBVar00664777
WBVar00301608
WBVar00664778
WBVar00100356
WBVar00664779
WBVar00664780
WBVar00664781
WBVar00664782
WBVar00664783
WBVar00664784
WBVar01932352
WBVar00664785
WBVar00664786
WBVar00664787
WBVar00664788
WBVar00664789
WBVar00664790
WBVar00664791
WBVar00664792
WBVar02128319
WBVar00664793
WBVar02128320
WBVar00664794
WBVar02128321
WBVar00664795
WBVar00664796
WBVar02128322
WBVar00664797
WBVar00214405
WBVar01343379
WBVar00664798
WBVar00664799
WBVar00664800
WBVar00664801
WBVar00664802
WBVar00664803
WBVar01492698
WBVar00664804
WBVar00664805
WBVar00664806
WBVar01498959
WBVar00664807
WBVar00664808
WBVar00664809
WBVar00664810
WBVar00664811
StrainWBStrain00031805
WBStrain00035918
RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (45)
ParalogWBGene00021629Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00011897Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018474Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionscpl-1 encodes, by alternative splicing, two protein isoforms of a putative class-C RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) phosphatase, orthologous to budding yeast PSR1 and PSR2 and human CTDSP1 (OMIM:605323), CTDSP2 (OMIM:608711, amplified in sarcoma), and CTDSPL (OMIM:608592, deleted in epithelial cancer), and paralogous to C. elegans SCPL-3 and human CTDSPL2; more distantly, SCPL-1 (and its paralog SCPL-3) are similar to SCPL-2, SCPL-4, and FCP-1; loss of scpl-1 activity via RNAi results in a slightly abnormal egg-laying response in the presence of serotonin; an scpl-1::gfp promoter fusion is expressed in pharyngeal, vulval, and body wall muscle; within body wall muscle, SCPL-1 localize to the M line and I band; SCPL-1 physically interacts with UNC-89 both in vitro and in vivo.Paper_evidenceWBPaper00029277
WBPaper00029278
WBPaper00029279
WBPaper00029280
WBPaper00031595
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated16 Dec 2011 00:00:00
Automated_descriptionEnables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16890)
Molecular_infoCorresponding_CDSB0379.4a
B0379.4b
B0379.4c
Corresponding_CDS_historyB0379.4:wp77
B0379.4a:wp103
B0379.4b:wp103
Corresponding_transcriptB0379.4a.1
B0379.4b.1
B0379.4c.1
Other_sequence (38)
Associated_feature (22)
Transcription_factorWBTranscriptionFactor000636
Experimental_infoRNAi_result (13)
Expr_patternChronogram589
Expr8052
Expr8053
Expr1015780
Expr1033029
Expr1143160
Expr2015647
Expr2033879
Drives_constructWBCnstr00002821
WBCnstr00013080
AntibodyWBAntibody00001386
WBAntibody00001387
Microarray_results (25)
Expression_cluster (94)
Interaction (39)
Map_infoMapIPosition4.63311Error0.019017
PositivePositive_cloneB0379Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5541
5251
Pseudo_map_position
Reference (11)
Remarktag-188 is parsed from CGC strain VC612
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene