WormBase Tree Display for Gene: WBGene00001393
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WBGene00001393 | SMap | S_parent | Sequence | Y67H2A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fat | ||||||
Allele | WBVar00093478 | Inferred_automatically | From strain object: RB1795 | ||||
WBVar00275131 | |||||||
WBVar00193358 | |||||||
WBVar00193359 | |||||||
WBVar01688378 | |||||||
WBVar01688379 | |||||||
WBVar02111770 | |||||||
WBVar00275119 | |||||||
WBVar00275122 | |||||||
WBVar01967462 | |||||||
WBVar01967463 | |||||||
WBVar01967464 | |||||||
WBVar01967465 | |||||||
WBVar01967466 | |||||||
WBVar01967467 | |||||||
WBVar02013529 | |||||||
WBVar01498996 | |||||||
WBVar00953447 | |||||||
WBVar00953448 | |||||||
WBVar01796525 | |||||||
WBVar01796526 | |||||||
WBVar00953449 | |||||||
WBVar01796527 | |||||||
WBVar00953450 | |||||||
WBVar00953451 | |||||||
WBVar00953452 | |||||||
WBVar00953453 | |||||||
WBVar00953454 | |||||||
WBVar01499925 | |||||||
WBVar00953455 | |||||||
WBVar00953456 | |||||||
WBVar00953457 | |||||||
WBVar01702997 | |||||||
WBVar00953458 | |||||||
WBVar00953459 | |||||||
WBVar00953460 | |||||||
WBVar00953461 | |||||||
WBVar02008384 | |||||||
WBVar02037468 | |||||||
WBVar02037469 | |||||||
WBVar02037470 | |||||||
WBVar01499951 | |||||||
WBVar01499952 | |||||||
WBVar02021428 | |||||||
WBVar02021429 | |||||||
WBVar02042309 | |||||||
WBVar02042310 | |||||||
WBVar02042311 | |||||||
WBVar02042312 | |||||||
WBVar02042313 | |||||||
WBVar02042314 | |||||||
WBVar02042315 | |||||||
WBVar02047157 | |||||||
WBVar02047158 | |||||||
WBVar02047159 | |||||||
WBVar01804907 | |||||||
WBVar00439457 | |||||||
WBVar00439458 | |||||||
WBVar01804908 | |||||||
WBVar00439459 | |||||||
WBVar01804909 | |||||||
WBVar00439460 | |||||||
WBVar01804910 | |||||||
WBVar02034547 | |||||||
WBVar01804911 | |||||||
WBVar00439461 | |||||||
WBVar01804912 | |||||||
WBVar01804913 | |||||||
WBVar01804914 | |||||||
WBVar01804915 | |||||||
WBVar01804916 | |||||||
WBVar01804917 | |||||||
WBVar01804918 | |||||||
WBVar01804919 | |||||||
WBVar01804920 | |||||||
WBVar01490827 | |||||||
WBVar02110258 | |||||||
WBVar01821325 | |||||||
WBVar01821326 | |||||||
WBVar02151580 | |||||||
WBVar01499492 | |||||||
WBVar01499493 | |||||||
WBVar02151223 | |||||||
WBVar01482578 | |||||||
WBVar01482579 | |||||||
WBVar01482580 | |||||||
WBVar01500245 | |||||||
WBVar01482581 | |||||||
WBVar00193355 | |||||||
WBVar00193356 | |||||||
WBVar00193357 | |||||||
Legacy_information | [C.elegansII] NMK. Encodes fatty acid desaturase (EST cm10e11), complements Arabidopsis mutant fad2 (deficient in 18:3 fatty acid synthesis). [CGC] | ||||||
Strain | WBStrain00032486 | ||||||
WBStrain00004010 | |||||||
WBStrain00004013 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (30) | |||||||
Paralog | WBGene00001394 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | fat-1 encodes an omega-3 fatty acyl desaturase that acts onsubstrates of 16-20 carbons with a preference for omega-6 fatty acids;FAT-1 dehydrogenates its substrates 3 carbons from the methyl terminus;FAT-1 is required in vivo for n3 polyunsaturated fatty acid (PUFA)synthesis; the fatty acids of fat-1(wa9) mutants consist of 20%arachidonic acid (20:4n6), instead of the 20% eicosapentaenoic acid(20:5n3) seen in wild-type worms; fat-1(wa9) mutants are generallynormal, with normal chemotaxis; fat-4(wa14) fat-1(wa9) double mutantsare superficially normal but have deficient chemotaxis to AWA-sensedodorants (though not to AWC-sensed ones), and mildly defectiveOSM-9/OCR-2-dependent nociception by ASH neurons; fat-1 mutants areabnormally sensitive to excess dihommogamma-linolenic acid (DGLA,20:3n-6), which induces degeneration of larval germ cells, excessapoptosis in adult germline, and sterility; while this sensitivity isenhanced by fat-4 mutations, it requires excess DGLA (or its precursor,gamma-linolenic acid/18:3n-6) in the food media; fat-1 or fat-1;fat-4mutants grown on normal food are fertile, despite their having excessDGLA in vivo; transgenic FAT-1 can lower apoptosis in cultured mammalianneurons, suggesting that it may be required for an evolutionarilyconserved signalling pathway regulating apoptosis. | Paper_evidence (11) | ||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 10 Jun 2010 00:00:00 | ||||||
Automated_description | Predicted to enable oxidoreductase activity. Involved in positive regulation of locomotion and unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045655 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jun 2019 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000709 | ||||||
Molecular_info | Corresponding_CDS | Y67H2A.8 | |||||
Corresponding_transcript | Y67H2A.8.1 | ||||||
Other_sequence (29) | |||||||
Associated_feature | WBsf716796 | ||||||
WBsf981840 | |||||||
WBsf998378 | |||||||
WBsf998379 | |||||||
WBsf229415 | |||||||
WBsf229416 | |||||||
WBsf229417 | |||||||
WBsf229418 | |||||||
Experimental_info | RNAi_result (20) | ||||||
Expr_pattern | Expr11476 | ||||||
Expr1014973 | |||||||
Expr1030833 | |||||||
Expr1161435 | |||||||
Expr2011434 | |||||||
Expr2029672 | |||||||
Drives_construct | WBCnstr00019042 | ||||||
WBCnstr00036976 | |||||||
Construct_product | WBCnstr00036976 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (195) | |||||||
Interaction (19) | |||||||
WBProcess | WBbiopr:00000121 | ||||||
Map_info | Map | IV | Position | 8.5225 | Error | 0.002181 | |
Positive | Positive_clone | Y67H2A | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4297 | |||||
4298 | |||||||
5570 | |||||||
Pseudo_map_position | |||||||
Reference (63) | |||||||
Remark | information received from Spychalla (Madison, John Browse lab) 02/95. | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |