WormBase Tree Display for Gene: WBGene00001131

WBGene00001131 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: dys-1 Person_evidence: WBPerson571
      Sequence_name: F15D3.1
      Molecular_name (30)
      Other_name: CELE_F15D3.1 Accession_evidence: NDB BX284601
      Public_name: dys-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dys
    Allele: WBVar00054722 Inferred_automatically: From strain object: LS292
          From strain object: LS587
          From strain object: LS617
          From strain object: LS706
      WBVar00604133 Inferred_automatically: From strain object: VC3239
      WBVar00054732
      WBVar00054752
      WBVar00054767
      WBVar01663467
      WBVar01285037
      WBVar00673101
      WBVar00346228
      WBVar00157323
      WBVar01663468
      WBVar00346229
      WBVar01285038
      WBVar00673102
      WBVar00157324
      WBVar00673103
      WBVar01663469
      WBVar00157325
      WBVar01285039
      WBVar01663470
      WBVar00673104
      WBVar00157326
      WBVar01285041
      WBVar02151980
      WBVar00157327
      WBVar00673105
      WBVar01285042
      WBVar01663471
      WBVar00673106
      WBVar01663472
      WBVar00157329
      WBVar01285043
      WBVar01663473
      WBVar00157330
      WBVar01285044
      WBVar00101148
      WBVar00673107
      WBVar00101149
      WBVar00673108
      WBVar01663474
      WBVar00157331
      WBVar01285048
      WBVar01285052
      WBVar00101150
      WBVar00157332
      WBVar00673109
      WBVar01663475
      WBVar01285054
      WBVar00157333
      WBVar01663476
      WBVar00673110
      WBVar00157334
      WBVar01663477
      WBVar00673111
      WBVar00673112
      WBVar00157335
      WBVar01663478
      WBVar01663479
      WBVar00157336
      WBVar00673113
      WBVar00673114
      WBVar00157337
      WBVar01663480
      WBVar00673115
      WBVar01663481
      WBVar00157338
      WBVar01836011
      WBVar01663482
      WBVar00673116
      WBVar01836012
      WBVar00673117
      WBVar01663483
      WBVar01663484
      WBVar00673118
      WBVar01491805
      WBVar01663485
      WBVar00673119
      WBVar01663486
      WBVar00673120
      WBVar00673121
      WBVar01663487
      WBVar00673122
      WBVar01663488
      WBVar01663489
      WBVar00673123
      WBVar01663490
      WBVar00256544
      WBVar00673124
      WBVar01663491
      WBVar00673125
      WBVar01663492
      WBVar00673126
      WBVar01663493
      WBVar00673127
      WBVar01349279
      WBVar01663494
      WBVar00673128
      WBVar01349283
      WBVar02128550
      WBVar01663495
      WBVar00673129
      WBVar00673130
      WBVar02128551
      WBVar01663496
      WBVar00673131
      WBVar01663497
      WBVar02128552
      WBVar02128553
      WBVar01663498
      WBVar00673132
      WBVar01900346
      WBVar02128554
      WBVar00673133
      WBVar01663499
      WBVar02128555
      WBVar00673134
      WBVar01663500
      WBVar00673135
      WBVar02128556
      WBVar01663501
      WBVar00673136
      WBVar01663502
      WBVar00673137
      WBVar01663503
      WBVar00673138
      WBVar01663504
      WBVar01663505
      WBVar00673139
      WBVar01499739
      WBVar00673140
      WBVar01663506
      WBVar00673141
      WBVar01663507
      WBVar00673142
      WBVar01663508
      WBVar00673143
      WBVar01663509
      WBVar01663510
      WBVar00673144
      WBVar00673145
      WBVar01663511
      WBVar00244517
      WBVar00673146
      WBVar01663512
      WBVar01663513
      WBVar00673147
      WBVar01663514
      WBVar00673148
      WBVar01663515
      WBVar00673149
      WBVar00673150
      WBVar01663516
      WBVar00673151
      WBVar01392150
      WBVar01663517
      WBVar01993385
      WBVar00673152
      WBVar01663518
      WBVar01392151
      WBVar01392152
      WBVar01663519
      WBVar00673153
      WBVar01392153
      WBVar01663520
      WBVar00539511
      WBVar00673154
      WBVar01476201
      WBVar01663521
      WBVar02097280
      WBVar00673155
      WBVar00539515
      WBVar01663522
      WBVar01476202
      WBVar00673156
      WBVar02097281
      WBVar00539516
      WBVar00539517
      WBVar00673157
      WBVar02097282
      WBVar01476203
      WBVar01663523
      WBVar02097283
      WBVar01476204
      WBVar00539520
      WBVar01663524
      WBVar00673158
      WBVar00673159
      WBVar01663525
      WBVar01476205
      WBVar00539522
      WBVar01663526
      WBVar00539524
      WBVar00673160
      WBVar01476206
      WBVar01663527
      WBVar00539528
      WBVar00673161
      WBVar00673162
      WBVar01894813
      WBVar01663528
      WBVar01497001
      WBVar00673163
      WBVar00240408
      WBVar01663529
      WBVar00673164
      WBVar01663530
      WBVar01663531
      WBVar00673165
      WBVar01890156
      WBVar01890157
      WBVar00673166
      WBVar01890158
      WBVar00673167
      WBVar00673168
      WBVar01890159
      WBVar01890160
      WBVar00673169
      WBVar01890161
      WBVar00673170
      WBVar01532268
      WBVar01890162
      WBVar00673171
      WBVar01532269
      WBVar00673172
      WBVar01890163
      WBVar01532270
      WBVar01890164
      WBVar00673173
      WBVar01532271
      WBVar00673174
      WBVar01890165
      WBVar00673175
      WBVar01890166
      WBVar01532272
      WBVar01890167
      WBVar01603002
      WBVar01532273
      WBVar01910359
      WBVar00673176
      WBVar01890168
      WBVar01532274
      WBVar00673177
      WBVar00673178
      WBVar01890169
      WBVar00673179
      WBVar01890170
      WBVar00673180
      WBVar01890171
      WBVar00673181
      WBVar01890172
      WBVar02146909
      WBVar00673182
      WBVar01890173
      WBVar02146911
      WBVar00673183
      WBVar00673184
      WBVar01490398
      WBVar00673185
      WBVar00673186
      WBVar00673187
      WBVar00234027
      WBVar00234028
      WBVar00673188
      WBVar00673189
      WBVar01499788
      WBVar00234029
      WBVar00673190
      WBVar00673191
      WBVar01499054
      WBVar01957813
      WBVar00673192
      WBVar00673193
      WBVar01957815
      WBVar00673194
      WBVar00673195
      WBVar00673196
      WBVar00673197
      WBVar00673198
      WBVar00673199
      WBVar01433179
      WBVar02069212
      WBVar01822929
      WBVar00673200
      WBVar00673201
      WBVar00673018
      WBVar00673202
      WBVar00673203
      WBVar00673019
      WBVar02079840
      WBVar00673020
      WBVar00673204
      WBVar02052741
      WBVar00673021
      WBVar00673205
      WBVar01713206
      WBVar00673206
      WBVar00673022
      WBVar00673023
      WBVar00673207
      WBVar01713207
      WBVar00673208
      WBVar00673024
      WBVar01681457
      WBVar01713208
      WBVar00673209
      WBVar00673025
      WBVar01713209
      WBVar00673210
      WBVar01713210
      WBVar00673026
      WBVar01713211
      WBVar00673211
      WBVar00673027
      WBVar00673028
      WBVar01713212
      WBVar02006274
      WBVar00673212
      WBVar01713213
      WBVar00673213
      WBVar00673029
      WBVar01713214
      WBVar01345623
      WBVar00673214
      WBVar00673030
      WBVar00673215
      WBVar00673031
      WBVar01713215
      WBVar00244249
      WBVar01345634
      WBVar01713216
      WBVar00673216
      WBVar00673032
      WBVar01713217
      WBVar00673033
      WBVar01345645
      WBVar00673217
      WBVar01345656
      WBVar00673034
      WBVar00673218
      WBVar01713218
      WBVar02075756
      WBVar01713219
      WBVar01345667
      WBVar00673219
      WBVar00673035
      WBVar01345678
      WBVar00673036
      WBVar01713220
      WBVar00673220
      WBVar02153522
      WBVar00673037
      WBVar01713221
      WBVar01345689
      WBVar00673221
      WBVar01826452
      WBVar01345700
      WBVar00673038
      WBVar01713222
      WBVar00673222
      WBVar00673223
      WBVar00673039
      WBVar01713223
      WBVar00673224
      WBVar00673040
      WBVar00346167
      WBVar01713224
      WBVar01713225
      WBVar00673041
      WBVar00673225
      WBVar01345712
      WBVar00346168
      WBVar01713226
      WBVar00673042
      WBVar00673226
      WBVar02151548
      WBVar00346169
      WBVar00346170
      WBVar00673043
      WBVar00673227
      WBVar01713227
      WBVar00346171
      WBVar01713228
      WBVar00673228
      WBVar00673044
      WBVar00346172
      WBVar00673229
      WBVar01713229
      WBVar00673045
      WBVar00346173
      WBVar00673046
      WBVar00673230
      WBVar01713230
      WBVar01345723
      WBVar02016441
      WBVar02014186
      WBVar00673047
      WBVar00673231
      WBVar00346174
      WBVar01713231
      WBVar02016442
      WBVar00673232
      WBVar01911893
      WBVar00346175
      WBVar01713232
      WBVar00673048
      WBVar02016443
      WBVar00673233
      WBVar00216115
      WBVar02016444
      WBVar01911894
      WBVar00346176
      WBVar00673049
      WBVar00673050
      WBVar01911895
      WBVar00673234
      WBVar00346177
      WBVar00216117
      WBVar00673051
      WBVar00673235
      WBVar00346178
      WBVar01911896
      WBVar00346179
      WBVar00673236
      WBVar00673052
      WBVar01932635
      WBVar00216119
      WBVar01911897
      WBVar00346180
      WBVar00673053
      WBVar00673237
      WBVar00216121
      WBVar01911898
      WBVar00306190
      WBVar00346181
      WBVar00673054
      WBVar00673238
      WBVar01911899
      WBVar01411821
      WBVar00216124
      WBVar00306191
      WBVar00673055
      WBVar01911900
      WBVar00346182
      WBVar00673239
      WBVar00216125
      WBVar00673240
      WBVar01911901
      WBVar00673056
      WBVar00346183
      WBVar00346184
      WBVar00216126
      WBVar01911902
      WBVar00673241
      WBVar00673057
      WBVar00346185
      WBVar01911903
      WBVar00264022
      WBVar00673058
      WBVar00673242
      WBVar00216127
      WBVar01911904
      WBVar00673243
      WBVar00673059
      WBVar00346186
      WBVar00216128
      WBVar01911905
      WBVar00216129
      WBVar00673244
      WBVar00673060
      WBVar00346187
      WBVar00673245
      WBVar00216130
      WBVar01911906
      WBVar00673061
      WBVar00346188
      WBVar00673246
      WBVar00346189
      WBVar00216132
      WBVar00673062
      WBVar00673063
      WBVar00673247
      WBVar00346190
      WBVar00216133
      WBVar00346191
      WBVar00673064
      WBVar00265868
      WBVar00673248
      WBVar00673249
      WBVar00346192
      WBVar00673065
      WBVar00673250
      WBVar00346193
      WBVar02072229
      WBVar00673066
      WBVar00346194
      WBVar00673251
      WBVar00673067
      WBVar00673252
      WBVar00346195
      WBVar00673068
      WBVar00346196
      WBVar00673069
      WBVar00673253
      WBVar00673070
      WBVar00346197
      WBVar00673254
      WBVar00346198
      WBVar00673255
      WBVar00673071
      WBVar00346199
      WBVar00673256
      WBVar00673072
      WBVar01424344
      WBVar01424355
      WBVar00673257
      WBVar00673073
      WBVar00346200
      WBVar01492128
      WBVar01424366
      WBVar00673258
      WBVar00673074
      WBVar00346201
      WBVar00673259
      WBVar01403519
      WBVar00346202
      WBVar00673075
      WBVar00278332
      WBVar00673076
      WBVar00346203
      WBVar00673260
      WBVar00673261
      WBVar00673077
      WBVar00346204
      WBVar00346205
      WBVar01491212
      WBVar00673078
      WBVar00346206
      WBVar00673079
      WBVar00673080
      WBVar00346207
      WBVar02073752
      WBVar02073753
      WBVar00673081
      WBVar00346208
      WBVar02001956
      WBVar00673082
      WBVar02073754
      WBVar00346209
      WBVar00346210
      WBVar00673083
      WBVar02073755
      WBVar00157305
      WBVar02001957
      WBVar01285002
      WBVar01285003
      WBVar02073756
      WBVar02001958
      WBVar00673084
      WBVar00157306
      WBVar00346211
      WBVar02001959
      WBVar01285004
      WBVar00346212
      WBVar00673085
      WBVar00157307
      WBVar00346213
      WBVar02001960
      WBVar01285006
      WBVar00673086
      WBVar00157308
      WBVar01285009
      WBVar00157309
      WBVar00673087
      WBVar02001961
      WBVar00346214
      WBVar00157310
      WBVar00673088
      WBVar00346215
      WBVar01285010
      WBVar02001962
      WBVar01285011
      WBVar00346216
      WBVar00157311
      WBVar02001963
      WBVar00673089
      WBVar00157312
      WBVar02001964
      WBVar00673090
      WBVar00346217
      WBVar01285012
      WBVar00346218
      WBVar02001965
      WBVar01285013
      WBVar00673091
      WBVar00157313
      WBVar00346219
      WBVar01285014
      WBVar01908061
      WBVar00157314
      WBVar02001966
      WBVar00673092
      WBVar01285015
      WBVar00157315
      WBVar00346220
      WBVar00673093
      WBVar02001967
      WBVar01285017
      WBVar00346221
      WBVar02001968
      WBVar00673094
      WBVar00157316
      WBVar00673095
      WBVar02001969
      WBVar01285023
      WBVar01663461
      WBVar00157317
      WBVar00346222
      WBVar00673096
      WBVar01498959
      WBVar02150291
      WBVar01663462
      WBVar02001970
      WBVar01285026
      WBVar00157318
      WBVar00346223
      WBVar00346224
      WBVar02001971
      WBVar00157319
      WBVar01663463
      WBVar00673097
      WBVar01663464
      WBVar00157320
      WBVar00346225
      WBVar01641153
      WBVar00673098
      WBVar00157321
      WBVar01663465
      WBVar01641154
      WBVar00673099
      WBVar01285030
      WBVar00346226
      WBVar00267312
      WBVar00346227
      WBVar01663466
      WBVar00673100
      WBVar00157322
      WBVar01285034
    Possibly_affected_by: WBVar02153522
    Strain: WBStrain00002611
      WBStrain00024335
      WBStrain00024340
      WBStrain00024342
      WBStrain00024343
      WBStrain00037736
      WBStrain00004037
      WBStrain00048693
    RNASeq_FPKM (74)
    GO_annotation (37)
    Ortholog (37)
    Structured_description: Concise_description: The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy (OMIM:310200). Paper_evidence: WBPaper00004103
            WBPaper00005175
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable actin binding activity and zinc ion binding activity. Involved in several processes, including forward locomotion; muscle cell cellular homeostasis; and sarcomere organization. Located in striated muscle dense body. Part of dystrobrevin complex. Expressed in body wall musculature; head muscle; pharyngeal muscle cell; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in several diseases, including Becker muscular dystrophy; Duchenne muscular dystrophy; cognitive disorder; dilated cardiomyopathy (multiple); and ovarian cancer. Is an ortholog of human DMD (dystrophin) and UTRN (utrophin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:11723 Homo sapiens Paper_evidence: WBPaper00003867
            WBPaper00003395
            WBPaper00044415
            WBPaper00035094
          Accession_evidence: OMIM 300376
              310200
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 May 2017 00:00:00
    Potential_model: DOID:11723 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
      DOID:0081164 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
      DOID:1561 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12635)
      DOID:0110461 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
      DOID:1059 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
      DOID:9883 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2928)
    Disease_relevance: Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; in C. elegans, loss-of-function mutants in dys-1 (cx18,cx26,cx35,cx40), the ortholog of human dystrophin/utrophin, display locomotion defects like hyperactivity and hypercontraction, and are hypersensitive to acetylcholine and to the acetylcholinesterase inhibitor, aldicarb, suggesting that dys-1 plays a role in the muscle response to acetylcholine; a chimeric transgene in which the C-terminal end of the elegans DYS-1 protein is replaced by the human dystrophin sequence is able to partly suppress the phenotype of the dys-1 mutants; however, the genetic model for progressive myopathy in C. elegans consists of the dys-1 mutation combined with a mutation in hlh-1, the MyoD ortholog (dys-1(cx18);hlh-1(cc561ts), these animals display time-dependent muscle degeneration; use of this model has identified several genes, that play a role in muscle degeneration, eg., dyc-1/nitric oxide synthase (nNOS)-binding protein CAPON. Homo sapiens Paper_evidence: WBPaper00003867
          Accession_evidence: OMIM 300377
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 May 2017 00:00:00
  Models_disease_asserted (21)
  Molecular_info: Corresponding_CDS: F15D3.1a
      F15D3.1b
      F15D3.1c
      F15D3.1d
      F15D3.1e
      F15D3.1f
      F15D3.1g
      F15D3.1h
      F15D3.1i
      F15D3.1j
    Corresponding_CDS_history: F15D3.1a:wp47
    Corresponding_transcript (10)
    Other_sequence (44)
    Associated_feature (19)
  Experimental_info: RNAi_result (13)
    Expr_pattern (12)
    Drives_construct: WBCnstr00003169
      WBCnstr00010181
    Construct_product: WBCnstr00007078
      WBCnstr00008412
      WBCnstr00010181
      WBCnstr00011497
    Regulate_expr_cluster: WBPaper00028474:dys-1_downregulated
      WBPaper00028474:dys-1_upregulated
    Antibody: WBAntibody00003001
    Microarray_results (34)
    Expression_cluster (142)
    Interaction (61)
  Map_info: Map: I Position: 9.11232
    Positive: Positive_clone: F15D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4272
        5386
    Pseudo_map_position
  Reference (86)
  Remark: Sequence connection from [Segalat L]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [210510 skd] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (9.05343)
  Method: Gene