WormBase Tree Display for Gene: WBGene00000156
expand all nodes | collapse all nodes | view schema
WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | apr-1 | Person_evidence | WBPerson419 | |||||
Sequence_name | K04G2.8 | ||||||||
Molecular_name | K04G2.8a | ||||||||
K04G2.8a.1 | |||||||||
CE06102 | |||||||||
K04G2.8b | |||||||||
CE18016 | |||||||||
K04G2.8c | |||||||||
CE51809 | |||||||||
K04G2.8b.1 | |||||||||
K04G2.8c.1 | |||||||||
Other_name | APC | Paper_evidence | WBPaper00044307 | ||||||
CELE_K04G2.8 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | apr-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | apr | ||||||||
Allele | WBVar00275469 | Inferred_automatically | From strain object: AH75 | ||||||
WBVar00296576 | Inferred_automatically | From strain object: HZ194 | |||||||
WBVar01491792 | |||||||||
WBVar00154850 | |||||||||
WBVar00154851 | |||||||||
WBVar00094057 | |||||||||
WBVar01574018 | |||||||||
WBVar00653058 | |||||||||
WBVar02016343 | |||||||||
WBVar00653059 | |||||||||
WBVar01894786 | |||||||||
WBVar00653060 | |||||||||
WBVar00653061 | |||||||||
WBVar00653062 | |||||||||
WBVar00653063 | |||||||||
WBVar01500105 | |||||||||
WBVar00653064 | |||||||||
WBVar01499739 | |||||||||
WBVar00653065 | |||||||||
WBVar00653066 | |||||||||
WBVar00653067 | |||||||||
WBVar00653068 | |||||||||
WBVar00653069 | |||||||||
WBVar00653070 | |||||||||
WBVar00653071 | |||||||||
WBVar00653072 | |||||||||
WBVar00653073 | |||||||||
WBVar00653074 | |||||||||
WBVar00653075 | |||||||||
WBVar00653076 | |||||||||
WBVar00653077 | |||||||||
WBVar00653078 | |||||||||
WBVar00653079 | |||||||||
WBVar00653080 | |||||||||
WBVar00653081 | |||||||||
WBVar00653082 | |||||||||
WBVar01495707 | |||||||||
WBVar00653083 | |||||||||
WBVar00653084 | |||||||||
WBVar00653085 | |||||||||
WBVar00653086 | |||||||||
WBVar00653087 | |||||||||
WBVar01498288 | |||||||||
WBVar00653088 | |||||||||
WBVar00653089 | |||||||||
WBVar01911828 | |||||||||
WBVar01681435 | |||||||||
WBVar01499786 | |||||||||
WBVar01499054 | |||||||||
WBVar02006265 | |||||||||
WBVar01641087 | |||||||||
WBVar01432239 | |||||||||
WBVar01432240 | |||||||||
WBVar01340690 | |||||||||
WBVar01340701 | |||||||||
WBVar01340713 | |||||||||
WBVar02127951 | |||||||||
WBVar00339401 | |||||||||
WBVar00339402 | |||||||||
WBVar00339403 | |||||||||
WBVar00339404 | |||||||||
WBVar00339405 | |||||||||
WBVar00339406 | |||||||||
WBVar00339407 | |||||||||
WBVar00339408 | |||||||||
WBVar00339409 | |||||||||
WBVar00339410 | |||||||||
WBVar01498959 | |||||||||
WBVar01420645 | |||||||||
Possibly_affected_by | WBVar02153202 | ||||||||
Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||||
Strain | WBStrain00037280 | ||||||||
WBStrain00000140 | |||||||||
WBStrain00008585 | |||||||||
WBStrain00024309 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (77) | |||||||||
Ortholog (41) | |||||||||
Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 25 May 2011 00:00:00 | ||||||||
Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (20) | ||||||||
Molecular_info | Corresponding_CDS | K04G2.8a | |||||||
K04G2.8b | |||||||||
K04G2.8c | |||||||||
Corresponding_transcript | K04G2.8a.1 | ||||||||
K04G2.8b.1 | |||||||||
K04G2.8c.1 | |||||||||
Other_sequence | AF013950 | ||||||||
CGC00612_1 | |||||||||
ACC25655_1 | |||||||||
EX555243.1 | |||||||||
CBC06635_1 | |||||||||
Associated_feature | WBsf656598 | ||||||||
WBsf218114 | |||||||||
Experimental_info | RNAi_result (104) | ||||||||
Expr_pattern (10) | |||||||||
Drives_construct | WBCnstr00005188 | ||||||||
WBCnstr00007256 | |||||||||
WBCnstr00009075 | |||||||||
WBCnstr00009116 | |||||||||
WBCnstr00012108 | |||||||||
WBCnstr00016098 | |||||||||
WBCnstr00020198 | |||||||||
WBCnstr00021087 | |||||||||
WBCnstr00037698 | |||||||||
Construct_product | WBCnstr00000526 | ||||||||
WBCnstr00007257 | |||||||||
WBCnstr00007258 | |||||||||
WBCnstr00009057 | |||||||||
WBCnstr00009075 | |||||||||
WBCnstr00012108 | |||||||||
WBCnstr00016098 | |||||||||
WBCnstr00020198 | |||||||||
WBCnstr00021087 | |||||||||
WBCnstr00037698 | |||||||||
Antibody | WBAntibody00000276 | ||||||||
WBAntibody00000277 | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (124) | |||||||||
Interaction (179) | |||||||||
WBProcess | WBbiopr:00000073 | ||||||||
Map_info (4) | |||||||||
Reference (108) | |||||||||
Picture | WBPicture0000013084 | ||||||||
Remark | Data extracted from Rocheleau et al. (1997) | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |