WormBase Tree Display for Gene: WBGene00000055
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WBGene00000055 | SMap | S_parent | Sequence | F25G6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | acr | ||||||
Allele | WBVar00464908 | ||||||
WBVar00464909 | |||||||
WBVar01499903 | |||||||
WBVar01825825 | |||||||
WBVar01500129 | |||||||
WBVar01911116 | |||||||
WBVar00092069 | |||||||
WBVar01499056 | |||||||
WBVar01031776 | |||||||
WBVar01031777 | |||||||
WBVar01031778 | |||||||
WBVar01031779 | |||||||
WBVar01031780 | |||||||
WBVar01031781 | |||||||
WBVar01031782 | |||||||
WBVar01031783 | |||||||
WBVar01031784 | |||||||
WBVar01031785 | |||||||
WBVar01031786 | |||||||
WBVar01031787 | |||||||
WBVar01031788 | |||||||
WBVar01031789 | |||||||
WBVar01031790 | |||||||
WBVar01848372 | |||||||
WBVar00250010 | |||||||
WBVar01661211 | |||||||
WBVar01651980 | |||||||
WBVar01499316 | |||||||
WBVar00464899 | |||||||
WBVar00464900 | |||||||
WBVar00464901 | |||||||
WBVar00464902 | |||||||
WBVar00464903 | |||||||
WBVar00464904 | |||||||
WBVar00464905 | |||||||
WBVar00464906 | |||||||
WBVar00464907 | |||||||
Strain | WBStrain00031630 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog (42) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that is required for the major fast cholinergic excitatory current at C. elegans neuromuscular junctions; when expressed in Xenopus ooctyes, ACR-16 is active as a homomeric receptor and responds robustly to acetylcholine; an ACR-16::GFP reporter fusion expressed in muscle cells localizes to the tips of muscle arms, specific regions of the muscle cell membrane that form synapses with neuronal processes; acr-16::gfp promoter fusions also reveal expression in a subset of neurons; ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity, is regulated by a Wnt signaling pathway that includes CWN-2, LIN-17, CAM-1, and DSH-1. | Paper_evidence | WBPaper00003425 | |||
WBPaper00004459 | |||||||
WBPaper00005427 | |||||||
WBPaper00005594 | |||||||
WBPaper00025245 | |||||||
WBPaper00040939 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 17 Apr 2012 00:00:00 | ||||||
Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic ion transmembrane transport. Located in cell projection. Expressed in body wall musculature; linker cell; muscle cell; and neurons. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00028761 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 22 May 2019 00:00:00 | ||||||
Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | |||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:7474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||
Models_disease_asserted | WBDOannot00000676 | ||||||
Molecular_info | Corresponding_CDS | F25G6.3 | |||||
Corresponding_CDS_history | F25G6.3a:wp246 | ||||||
F25G6.3b:wp246 | |||||||
Corresponding_transcript | F25G6.3.1 | ||||||
Other_sequence (27) | |||||||
Associated_feature | WBsf1000696 | ||||||
WBsf1000697 | |||||||
WBsf232121 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern (13) | |||||||
Drives_construct | WBCnstr00004901 | ||||||
WBCnstr00004902 | |||||||
WBCnstr00004903 | |||||||
WBCnstr00004904 | |||||||
WBCnstr00004905 | |||||||
WBCnstr00009872 | |||||||
WBCnstr00011440 | |||||||
WBCnstr00011957 | |||||||
WBCnstr00017746 | |||||||
WBCnstr00018183 | |||||||
Construct_product | WBCnstr00001360 | ||||||
WBCnstr00006788 | |||||||
WBCnstr00009355 | |||||||
WBCnstr00011441 | |||||||
WBCnstr00014504 | |||||||
WBCnstr00020316 | |||||||
Antibody | WBAntibody00001986 | ||||||
Microarray_results (30) | |||||||
Expression_cluster (125) | |||||||
Interaction (28) | |||||||
Map_info | Map | V | Position | 1.46223 | Error | 0.003864 | |
Positive | Positive_clone | F25G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4869 | |||||
5605 | |||||||
Pseudo_map_position | |||||||
Reference (89) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |