WormBase Tree Display for Variation: WBVar00092069

WBVar00092069 Name: Public_name: ok789
    Other_name: F25G6.3.1:c.492+8_988-4del
    HGVSg: CHROMOSOME_V:g.8562086_8563167del
  Sequence_details: SMap: S_parent: Sequence: F25G6
    Flanking_sequences: acgagcaaaaatgtttctttaaagtaagtt cagacacgtaacctccttctctattggatt
    Mapping_target: F25G6
    Type_of_mutation: Deletion
    PCR_product: ok789_external
      ok789_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00031630
      WBStrain00048065
      WBStrain00048067
      WBStrain00048068
      WBStrain00048072
      WBStrain00048080
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00000055
    Transcript: F25G6.3.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F25G6.3.1:c.492+8_988-4del
        Intron_number: 4-9/11
        Exon_number: 5-9/12
    Interactor: WBInteraction000501251
      WBInteraction000501252
      WBInteraction000518502
  Isolation: Mutagen: UV/TMP
  Description: Phenotype: WBPhenotype:0000039 Paper_evidence: WBPaper00040570
        Curator_confirmed: WBPerson8126
        Remark: Fig.6 (lifespan extension upon reserpine treatment, not different from wild type) Paper_evidence: WBPaper00040570
            Curator_confirmed: WBPerson8126
        Affected_by: Molecule: WBMol:00002955 Paper_evidence: WBPaper00040570
              Curator_confirmed: WBPerson8126
      WBPhenotype:0000656 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: acr-16 mutants show largely reduced peak currents in response to sustained release of ACh, compared to wild-type Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001316 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: ACh and nicotine-evoked PSCs were significantly reduced in acr-16 mutants Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001852 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: Mutants are susceptible to tribendimidine Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000421 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: acr-16 mutants are not resistant to levamisole Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00034730
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00041959
          WBPaper00046043
        Curator_confirmed: WBPerson557
          WBPerson28327
      WBPhenotype:0000681 Paper_evidence: WBPaper00027611
        Curator_confirmed: WBPerson712
        Remark: Scored as DMPP sensitive. Paper_evidence: WBPaper00027611
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00000896 Paper_evidence: WBPaper00027611
              Curator_confirmed: WBPerson712
      WBPhenotype:0000886 Paper_evidence: WBPaper00035548
        Curator_confirmed: WBPerson712
        Remark: Animals are superficially wild-type. Paper_evidence: WBPaper00035548
            Curator_confirmed: WBPerson712
      WBPhenotype:0001203 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: acr-16 mutants are not resistant to nicotine Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001468 Paper_evidence: WBPaper00041959
        Curator_confirmed: WBPerson557
        Remark: Mutant worms exhibited a normal approach to a benzaldehyde stimulus. Paper_evidence: WBPaper00041959
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Worms placed on chemotaxis plates spotted with 0.01% benzaldehyde. Paper_evidence: WBPaper00041959
              Curator_confirmed: WBPerson557
      WBPhenotype:0001700 Paper_evidence: WBPaper00032995
        Curator_confirmed: WBPerson2021
        Remark: No obvious swimming defects in mutants Paper_evidence: WBPaper00032995
            Curator_confirmed: WBPerson2021
  Disease_info: Models_disease: DOID:0050742
    Models_disease_in_annotation: WBDOannot00000676
  Reference (11)
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele