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WormBase Tree Display for Gene: WBGene00000584

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Name Class

WBGene00000584EvidencePaper_evidenceWBPaper00005610
SMapS_parentSequenceR03C1
IdentityVersion1
NameCGC_namecog-1Person_evidenceWBPerson625
Sequence_nameR03C1.3
Molecular_nameR03C1.3a
R03C1.3a.1
CE25964
R03C1.3b
CE33290
R03C1.3b.1
Other_nameCELE_R03C1.3Accession_evidenceNDBBX284602
Public_namecog-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcog
AlleleWBVar00094846Inferred_automaticallyFrom strain object: OH3487
WBVar00094849Inferred_automaticallyFrom strain object: OH3491
WBVar00094905Inferred_automaticallyFrom strain object: OH3903
WBVar01832284
WBVar01499702
WBVar01548160
WBVar01548161
WBVar01548162
WBVar01548163
WBVar00248955
WBVar01498435
WBVar01253945
WBVar01961190
WBVar01253948
WBVar01253950
WBVar01961191
WBVar01950705
WBVar01253951
WBVar01950706
WBVar01950707
WBVar01852178
WBVar01415028
WBVar00257661
WBVar00257662
WBVar00094790
WBVar00094796
WBVar00249019
WBVar00094800
WBVar01944290
WBVar01321292
WBVar01321294
WBVar01321298
WBVar01321302
WBVar01321303
WBVar01385679
WBVar00094825
WBVar01321305
WBVar01321307
WBVar00259910
WBVar00094833
WBVar00557439
WBVar00557440
WBVar00094836
WBVar00557443
WBVar00557444
WBVar00094840
WBVar00557445
WBVar00094844
WBVar00245753
WBVar00094852
WBVar01442619
WBVar01442620
WBVar00792026
WBVar00792027
WBVar01442622
WBVar00792028
WBVar00792029
WBVar01896170
WBVar00792030
WBVar01896171
WBVar00792031
WBVar01401003
WBVar00792032
WBVar00792033
WBVar00792034
WBVar00792035
WBVar00792036
WBVar00792037
WBVar00792038
WBVar00792039
WBVar00792040
WBVar00792041
WBVar00792042
WBVar00792043
WBVar00792044
WBVar00094876
WBVar00792045
WBVar00792046
WBVar00792047
WBVar00258104
WBVar00792048
WBVar00792049
WBVar00792050
WBVar00792051
WBVar00019298
WBVar00792052
WBVar00792053
WBVar00792054
WBVar00019303
WBVar00792055
WBVar00792056
WBVar00019308
WBVar00792057
WBVar00792058
WBVar00792059
WBVar00019313
WBVar00792060
WBVar00792061
WBVar00792062
WBVar00792063
WBVar00019318
WBVar00094901
WBVar00792064
WBVar01395855
WBVar00792065
WBVar00019323
WBVar00792066
WBVar00094904
WBVar00019328
WBVar00019333
WBVar00019338
WBVar00094918
WBVar00264387
WBVar00094920
WBVar01696627
WBVar00094921
WBVar00386112
WBVar00019343
WBVar01696628
WBVar00386113
WBVar00386114
WBVar00386115
WBVar00386116
WBVar00386117
WBVar00386118
WBVar00386119
WBVar00386120
WBVar00094940
WBVar01498941
WBVar01267995
WBVar01499314
WBVar00277035
WBVar01268006
WBVar02068545
WBVar01268017
WBVar00001786
Legacy_informationcog for Connection of Gonad defective, adults are Egl with abnormal vulval morphology and abnormal connection between uterus and vulva, males are sperm transfer defective with abnormal connection between the vas deferens and the proctodeum
StrainWBStrain00030905
WBStrain00030922
WBStrain00030960
WBStrain00030961
WBStrain00029285
WBStrain00029298
WBStrain00029369
WBStrain00029370
WBStrain00029374
WBStrain00029386
WBStrain00029387
WBStrain00029435
WBStrain00030864
WBStrain00030887
WBStrain00030904
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (41)
ParalogWBGene00000428Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000434Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000445Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000447Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000449Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000450Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptioncog-1 encodes the C. elegans ortholog of the vertebrate Nkx6 homeodomain proteins; cog-1 activity is required for multiple aspects of reproductive system development, including connection of uterus to the vulva and vulval cell specification, as well as for specification of left/right asymmetry in the ASE taste receptor sensory neurons where cog-1 acts in ASER to suppress the ASEL cell fate; cog-1 expression in ASEL is negatively regulated by the lsy-6 miRNA; a cog-1::gfp reporter fusion is expressed in neurons and in the hermaphrodite vulva and uterus; in males, cog-1::gfp expression is seen in proctodeal cells and occasionally in the rectal Rep cells and P11.pp progeny.Paper_evidenceWBPaper00005610
WBPaper00006052
WBPaper00006260
WBPaper00031556
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated24 Feb 2009 00:00:00
Automated_descriptionEnables DNA-binding transcription factor binding activity. Involved in several processes, including determination of left/right symmetry; neuron development involved in amphid sensory organ development; and regulation of gene expression. Predicted to be located in nucleus. Expressed in several structures, including body ganglion; egg-laying apparatus; head neurons; male-specific anatomical entity; and tail ganglion. Human ortholog(s) of this gene implicated in spastic ataxia 8. Is an ortholog of human NKX6-1 (NK6 homeobox 1) and NKX6-2 (NK6 homeobox 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080252Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:19321)
Molecular_infoCorresponding_CDSR03C1.3a
R03C1.3b
Corresponding_transcriptR03C1.3a.1
R03C1.3b.1
Other_sequence (13)
Associated_feature (16)
Transcription_factorWBTranscriptionFactor000687
Experimental_infoRNAi_resultWBRNAi00107689Inferred_automaticallyRNAi_primary
WBRNAi00001218Inferred_automaticallyRNAi_primary
WBRNAi00051169Inferred_automaticallyRNAi_primary
WBRNAi00017345Inferred_automaticallyRNAi_primary
WBRNAi00062927Inferred_automaticallyRNAi_primary
WBRNAi00034550Inferred_automaticallyRNAi_primary
Expr_pattern (15)
Drives_constructWBCnstr00004665
WBCnstr00004666
WBCnstr00004672
WBCnstr00006876
WBCnstr00006877
WBCnstr00014600
WBCnstr00017428
WBCnstr00023015
WBCnstr00037445
WBCnstr00042865
Construct_productWBCnstr00006104
WBCnstr00006105
WBCnstr00007700
WBCnstr00016151
WBCnstr00017428
WBCnstr00021774
WBCnstr00037445
Microarray_results (30)
Expression_cluster (124)
Interaction (143)
Map_infoMapIIPosition23.6958Error0.059369
Well_ordered
PositivePositive_cloneR03C1Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneR13D4
Mapping_dataMulti_point3511
3512
4085
4193
5524
Pos_neg_data9070
9071
9072
9073
9074
9075
Reference (67)
MethodGene