WormBase Tree Display for Gene: WBGene00000156

WBGene00000156 SMap: S_parent: Sequence: K04G2
  Identity: Version: 1
    Name: CGC_name: apr-1 Person_evidence: WBPerson419
      Sequence_name: K04G2.8
      Molecular_name: K04G2.8a
        K04G2.8a.1
        CE06102
        K04G2.8b
        CE18016
        K04G2.8c
        CE51809
        K04G2.8b.1
        K04G2.8c.1
      Other_name: APC Paper_evidence: WBPaper00044307
        CELE_K04G2.8 Accession_evidence: NDB BX284601
      Public_name: apr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: apr
    Allele: WBVar00275469 Inferred_automatically: From strain object: AH75
      WBVar00296576 Inferred_automatically: From strain object: HZ194
      WBVar01491792
      WBVar00154850
      WBVar00154851
      WBVar00094057
      WBVar01574018
      WBVar00653058
      WBVar02016343
      WBVar00653059
      WBVar01894786
      WBVar00653060
      WBVar00653061
      WBVar00653062
      WBVar00653063
      WBVar01500105
      WBVar00653064
      WBVar01499739
      WBVar00653065
      WBVar00653066
      WBVar00653067
      WBVar00653068
      WBVar00653069
      WBVar00653070
      WBVar00653071
      WBVar00653072
      WBVar00653073
      WBVar00653074
      WBVar00653075
      WBVar00653076
      WBVar00653077
      WBVar00653078
      WBVar00653079
      WBVar00653080
      WBVar00653081
      WBVar00653082
      WBVar01495707
      WBVar00653083
      WBVar00653084
      WBVar00653085
      WBVar00653086
      WBVar00653087
      WBVar01498288
      WBVar00653088
      WBVar00653089
      WBVar01911828
      WBVar01681435
      WBVar01499786
      WBVar01499054
      WBVar02006265
      WBVar01641087
      WBVar01432239
      WBVar01432240
      WBVar01340690
      WBVar01340701
      WBVar01340713
      WBVar02127951
      WBVar00339401
      WBVar00339402
      WBVar00339403
      WBVar00339404
      WBVar00339405
      WBVar00339406
      WBVar00339407
      WBVar00339408
      WBVar00339409
      WBVar00339410
      WBVar01498959
      WBVar01420645
    Possibly_affected_by: WBVar02153202
    Legacy_information: [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01]
    Strain: WBStrain00037280
      WBStrain00000140
      WBStrain00008585
      WBStrain00024309
    RNASeq_FPKM (74)
    GO_annotation (77)
    Ortholog: WBGene00070008 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00030061 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00146816 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00150302 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00099225 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
      WBGene00122252 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00225075 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10245 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7151 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g19096 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7928 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g4841 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12319 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16913 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g8287 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6146 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g850 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g14192 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g16935 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00301.g8801 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-apr-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp5_scaffold_00160.g5962 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_13198 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_000446 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10596 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g7404 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10063300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1515 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237733 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00262578 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00293892 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0026598 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0015589 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-031112-7 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
      ZFIN:ZDB-GENE-090422-1 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      HGNC:583 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      HGNC:24036 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      MGI:88039 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      MGI:1346052 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      RGD:2123 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      RGD:1308256 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
    Structured_description: Concise_description: The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. Paper_evidence (12)
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 25 May 2011 00:00:00
      Automated_description: Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (20)
  Molecular_info: Corresponding_CDS: K04G2.8a
      K04G2.8b
      K04G2.8c
    Corresponding_transcript: K04G2.8a.1
      K04G2.8b.1
      K04G2.8c.1
    Other_sequence: AF013950
      CGC00612_1
      ACC25655_1
      EX555243.1
      CBC06635_1
    Associated_feature: WBsf656598
      WBsf218114
  Experimental_info: RNAi_result (104)
    Expr_pattern: Expr1046
      Expr4600
      Expr12119
      Expr12448
      Expr15118
      Expr1028112
      Expr1030085
      Expr1153646
      Expr2009365
      Expr2027601
    Drives_construct: WBCnstr00005188
      WBCnstr00007256
      WBCnstr00009075
      WBCnstr00009116
      WBCnstr00012108
      WBCnstr00016098
      WBCnstr00020198
      WBCnstr00021087
      WBCnstr00037698
    Construct_product: WBCnstr00000526
      WBCnstr00007257
      WBCnstr00007258
      WBCnstr00009057
      WBCnstr00009075
      WBCnstr00012108
      WBCnstr00016098
      WBCnstr00020198
      WBCnstr00021087
      WBCnstr00037698
    Antibody: WBAntibody00000276
      WBAntibody00000277
    Microarray_results (25)
    Expression_cluster (124)
    Interaction (179)
    WBProcess: WBbiopr:00000073
  Map_info: Map: I Position: 2.43771 Error: 0.002342
    Positive: Positive_clone: K04G2 Person_evidence: WBPerson524
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4159
        4893
        5616
    Pseudo_map_position
  Reference: WBPaper00002869
    WBPaper00002871
    WBPaper00002974
    WBPaper00003170
    WBPaper00003217
    WBPaper00003313
    WBPaper00003321
    WBPaper00003645
    WBPaper00003768
    WBPaper00003945
    WBPaper00003991
    WBPaper00004115
    WBPaper00004250
    WBPaper00004402
    WBPaper00004489
    WBPaper00004493
    WBPaper00004509
    WBPaper00004550
    WBPaper00004579
    WBPaper00004885
    WBPaper00004964
    WBPaper00005277
    WBPaper00005278
    WBPaper00005341
    WBPaper00005375
    WBPaper00005423
    WBPaper00005445
    WBPaper00005451
    WBPaper00005654
    WBPaper00006196
    WBPaper00006419
    WBPaper00010458
    WBPaper00010665
    WBPaper00010775
    WBPaper00011122
    WBPaper00011263
    WBPaper00011774
    WBPaper00015512
    WBPaper00015722
    WBPaper00017519
    WBPaper00017709
    WBPaper00017751
    WBPaper00017908
    WBPaper00018117
    WBPaper00018126
    WBPaper00018127
    WBPaper00018137
    WBPaper00018522
    WBPaper00018685
    WBPaper00018689
    WBPaper00019770
    WBPaper00019804
    WBPaper00023137
    WBPaper00023433
    WBPaper00025001
    WBPaper00025595
    WBPaper00025814
    WBPaper00026002
    WBPaper00026652
    WBPaper00026736
    WBPaper00027236
    WBPaper00027245
    WBPaper00027318
    WBPaper00027345
    WBPaper00027543
    WBPaper00028436
    WBPaper00029082
    WBPaper00030820
    WBPaper00031416
    WBPaper00032465
    WBPaper00034732
    WBPaper00034817
    WBPaper00035874
    WBPaper00036055
    WBPaper00036466
    WBPaper00036545
    WBPaper00036993
    WBPaper00037107
    WBPaper00038491
    WBPaper00038611
    WBPaper00038716
    WBPaper00039931
    WBPaper00040200
    WBPaper00041726
    WBPaper00042957
    WBPaper00044307
    WBPaper00045179
    WBPaper00045213
    WBPaper00045652
    WBPaper00046295
    WBPaper00048173
    WBPaper00048493
    WBPaper00048523
    WBPaper00051102
    WBPaper00052123
    WBPaper00053616
    WBPaper00054545
    WBPaper00055090
    WBPaper00057681
    WBPaper00057858
    WBPaper00059010
    WBPaper00059401
    WBPaper00059980
    WBPaper00060897
    WBPaper00061452
    WBPaper00061708
    WBPaper00063938
    WBPaper00064680
  Picture: WBPicture0000013084
  Remark: Data extracted from Rocheleau et al. (1997)
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene