peb-1 encodes a novel DNA-binding protein; during development, peb-1 activity is required for proper morphogenesis of the pharynx, vulva, and hindgut and for normal molting, feeding, and body morphology; in vitro, PEB-1 exhibits sequence-specific DNA binding to a regulatory sequence known as subelement C, which directs pharynx-specific myo-2 expression and in yeast, PEB-1 exhibits modest transcription activation activity; PEB-1 is expressed in the nuclei of all pharyngeal cells (except neurons) from the comma stage of embryogenesis through late larval stages; in addition, PEB-1 is expressed dynamically in non-pharyngeal cells, including the vulva, germline, hindgut, and hypodermis.
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including germ line; hypodermis; pharyngeal cell; pharyngeal-intestinal valve; and rectal epithelial cell.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.