WormBase Tree Display for Gene: WBGene00000419

WBGene00000419 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: ced-5 Person_evidence: WBPerson261
      Sequence_name: C02F4.1
      Molecular_name: C02F4.1
        C02F4.1.1
        CE24779
      Other_name: CELE_C02F4.1 Accession_evidence: NDB BX284604
      Public_name: ced-5
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ced
    Allele: WBVar00090328 Inferred_automatically: From strain object: MT4962
      WBVar00090354 Inferred_automatically: From strain object: MT7169
          From strain object: MT7170
          From strain object: MT7502
      WBVar00090551
      WBVar01730706
      WBVar01730707
      WBVar00937956
      WBVar00937957
      WBVar00937958
      WBVar00937959
      WBVar00937960
      WBVar01500079
      WBVar00937961
      WBVar00937962
      WBVar00937963
      WBVar00937964
      WBVar00937965
      WBVar00937966
      WBVar00937967
      WBVar00937968
      WBVar00937969
      WBVar00937970
      WBVar00937971
      WBVar01966920
      WBVar00937972
      WBVar00937973
      WBVar00937974
      WBVar00937975
      WBVar00937976
      WBVar00937977
      WBVar02147040
      WBVar00937978
      WBVar00937979
      WBVar00937980
      WBVar00937981
      WBVar00937982
      WBVar01498996
      WBVar00937983
      WBVar00937984
      WBVar00937985
      WBVar00937986
      WBVar00937987
      WBVar00937988
      WBVar00937989
      WBVar00937990
      WBVar00937991
      WBVar01499925
      WBVar00937992
      WBVar00937993
      WBVar00937994
      WBVar00937995
      WBVar00937996
      WBVar00937997
      WBVar00937998
      WBVar00937999
      WBVar00938000
      WBVar00938001
      WBVar00938002
      WBVar00938003
      WBVar02037098
      WBVar00938004
      WBVar00938005
      WBVar02037099
      WBVar01516383
      WBVar01482300
      WBVar00300060
      WBVar00250909
      WBVar00250910
      WBVar01857050
      WBVar01857051
      WBVar01857052
      WBVar01857053
      WBVar01857054
      WBVar01857055
      WBVar01857056
      WBVar01857057
      WBVar01857058
      WBVar01857059
      WBVar02134556
      WBVar02058693
      WBVar02058694
      WBVar00191799
      WBVar00090268
      WBVar01795346
      WBVar01795347
      WBVar01795348
      WBVar01453964
      WBVar01453965
      WBVar02021134
      WBVar02021135
      WBVar00434151
      WBVar00434152
      WBVar00434153
      WBVar00434154
      WBVar00434155
      WBVar00434156
      WBVar00434157
      WBVar00434158
      WBVar00434159
      WBVar00434160
      WBVar00434161
      WBVar00434162
      WBVar00434163
      WBVar00091779
      WBVar01398343
      WBVar01500245
      WBVar01730705
    Legacy_information: [C.elegansII] n1812 : programmmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); Mig, hermaphrodite distal tip cells execute extra turns; extensive maternal rescue; no gross phenotype. OA1: n2002.Cloned : 5.6 kb transcript, predicted protein 180 kD, novel.[Ellis et al. 1991; MT; NF; ZB]
      [C.elegansII] n1812 : programmmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); Mig, hermaphrodite distal tip cells execute extra turns; extensive maternal rescue; no gross phenotype. OA1: n2002.Cloned : 5.6 kb transcript, predicted protein 180 kD, novel. [Ellis et al. 1991; MT; NF; ZB]
      [Wu Y-C, Horvitz HR] Encodes 1781 aa predicted protein with similarity to human protein DOCK180. n1812 is stop at codon 28, n2002, n2691 also nonsense mutations, m2098, n2099 are splice acceptor mutations. n1812/sDf2 resemble n1812/n1812, probable null phenotype. Predicted gene C02F4.1
    Strain: WBStrain00027132
      WBStrain00027134
      WBStrain00027167
      WBStrain00027174
      WBStrain00027281
      WBStrain00027282
      WBStrain00027293
      WBStrain00027342
      WBStrain00031450
    RNASeq_FPKM (74)
    GO_annotation (48)
    Ortholog (59)
    Paralog: WBGene00009065 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018520 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ced-5 encodes a homolog of the human protein DOCK180; ced-5 is required for the cell engulfment stage of programmed cell death, and physically interacts with CED-2. Paper_evidence: WBPaper00003036
            WBPaper00003948
            WBPaper00005004
            WBPaper00012851
            WBPaper00013593
            WBPaper00013632
            WBPaper00038460
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 29 Jun 2012 00:00:00
      Automated_description: Enables SH3 domain binding activity and enzyme binding activity. Involved in several processes, including left/right axis specification; positive regulation of distal tip cell migration; and vesicle-mediated transport. Located in presynapse. Part of guanyl-nucleotide exchange factor complex. Expressed in body wall muscle cell; hermaphrodite somatic gonadal cell; and intestinal cell. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and immunodeficiency 40. Is an ortholog of human DOCK2 (dedicator of cytokinesis 2) and DOCK5 (dedicator of cytokinesis 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111951 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2988)
      DOID:1094 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2989)
  Molecular_info: Corresponding_CDS: C02F4.1
    Corresponding_transcript: C02F4.1.1
    Other_sequence (13)
    Associated_feature: WBsf646307
      WBsf660584
      WBsf976954
      WBsf976955
      WBsf976956
      WBsf228996
      WBsf228997
      WBsf228998
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr8762
      Expr14253
      Expr1020545
      Expr1030235
      Expr1143552
      Expr2009849
      Expr2028089
    Drives_construct: WBCnstr00005770
      WBCnstr00037557
      WBCnstr00040684
    Construct_product: WBCnstr00014899
      WBCnstr00037557
    Microarray_results (24)
    Expression_cluster (132)
    Interaction: WBInteraction000000969
      WBInteraction000001301
      WBInteraction000001433
      WBInteraction000001553
      WBInteraction000002561
      WBInteraction000002562
      WBInteraction000002563
      WBInteraction000002571
      WBInteraction000002572
      WBInteraction000002575
      WBInteraction000002576
      WBInteraction000002578
      WBInteraction000002790
      WBInteraction000002791
      WBInteraction000002794
      WBInteraction000003061
      WBInteraction000003062
      WBInteraction000004604
      WBInteraction000005075
      WBInteraction000005162
      WBInteraction000005163
      WBInteraction000005425
      WBInteraction000005426
      WBInteraction000008732
      WBInteraction000008735
      WBInteraction000008795
      WBInteraction000009290
      WBInteraction000009291
      WBInteraction000009671
      WBInteraction000009699
      WBInteraction000028770
      WBInteraction000029177
      WBInteraction000029193
      WBInteraction000029215
      WBInteraction000029720
      WBInteraction000030036
      WBInteraction000033207
      WBInteraction000033208
      WBInteraction000043117
      WBInteraction000047155
      WBInteraction000048575
      WBInteraction000048576
      WBInteraction000048577
      WBInteraction000048578
      WBInteraction000048579
      WBInteraction000048580
      WBInteraction000048581
      WBInteraction000048582
      WBInteraction000049678
      WBInteraction000049856
      WBInteraction000050647
      WBInteraction000051416
      WBInteraction000051417
      WBInteraction000051420
      WBInteraction000051421
      WBInteraction000051422
      WBInteraction000052285
      WBInteraction000052378
      WBInteraction000052382
      WBInteraction000052383
      WBInteraction000121211
      WBInteraction000126075
      WBInteraction000126076
      WBInteraction000126077
      WBInteraction000126078
      WBInteraction000126380
      WBInteraction000126993
      WBInteraction000127208
      WBInteraction000134847
      WBInteraction000136688
      WBInteraction000140447
      WBInteraction000148976
      WBInteraction000151463
      WBInteraction000164125
      WBInteraction000165530
      WBInteraction000165531
      WBInteraction000167046
      WBInteraction000167047
      WBInteraction000167048
      WBInteraction000174661
      WBInteraction000198504
      WBInteraction000211454
      WBInteraction000229167
      WBInteraction000300334
      WBInteraction000317876
      WBInteraction000339617
      WBInteraction000343827
      WBInteraction000353189
      WBInteraction000385032
      WBInteraction000422208
      WBInteraction000430089
      WBInteraction000437138
      WBInteraction000451715
      WBInteraction000469939
      WBInteraction000500582
      WBInteraction000501094
      WBInteraction000504718
      WBInteraction000517322
      WBInteraction000517323
      WBInteraction000517329
      WBInteraction000517330
      WBInteraction000517332
      WBInteraction000517345
      WBInteraction000517346
      WBInteraction000518045
      WBInteraction000518552
      WBInteraction000518606
      WBInteraction000518609
      WBInteraction000518993
      WBInteraction000518994
      WBInteraction000519000
      WBInteraction000519001
      WBInteraction000520139
      WBInteraction000521317
      WBInteraction000521815
      WBInteraction000522447
      WBInteraction000522448
      WBInteraction000522582
      WBInteraction000522584
      WBInteraction000541274
      WBInteraction000541399
      WBInteraction000541400
      WBInteraction000541420
      WBInteraction000546001
      WBInteraction000546730
      WBInteraction000556410
      WBInteraction000556872
      WBInteraction000557028
      WBInteraction000557029
    WBProcess: WBbiopr:00000013
      WBbiopr:00000014
      WBbiopr:00000015
      WBbiopr:00000023
      WBbiopr:00000107
  Map_info: Map: IV Position: 4.61067 Error: 0.002681
    Well_ordered
    Positive: Positive_clone: C02F4 Inferred_automatically: From sequence, transcript, pseudogene data
        ZK188
    Mapping_data: Multi_point: 1517
        1518
        1520
        1521
        1522
        1523
        1820
        1822
        4720
      Pos_neg_data: 4243
  Reference (191)
  Method: Gene