WormBase Tree Display for Gene: WBGene00012448

WBGene00012448 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: cyp-33D3
      Sequence_name: Y17D7A.4
      Molecular_name: Y17D7A.4
        Y17D7A.4.1
        CE16589
      Other_name: CELE_Y17D7A.4 Accession_evidence: NDB BX284605
      Public_name: cyp-33D3
    DB_info: Database: AceView gene 5T310
        WormQTL gene WBGene00012448
        WormFlux gene WBGene00012448
        NDB locus_tag CELE_Y17D7A.4
        Panther gene CAEEL|WormBase=WBGene00012448|UniProtKB=G5EE22
          family PTHR24300
        NCBI gene 189444
        RefSeq protein NM_075278.4
        TrEMBL UniProtAcc G5EE22
        UniProt_GCRP UniProtAcc G5EE22
        OMIM gene 601130
            608713
            610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-33D3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele: WBVar01096106
      WBVar01096107
      WBVar01096108
      WBVar01096109
      WBVar01096110
      WBVar01096111
      WBVar01096112
      WBVar01096113
      WBVar01750402
      WBVar00091259
      WBVar01096114
      WBVar01750403
      WBVar01499709
      WBVar01096115
      WBVar01750404
      WBVar01096116
      WBVar01096117
      WBVar02025594
      WBVar02025595
      WBVar01096118
      WBVar01096119
      WBVar02025596
      WBVar01096120
      WBVar00062531
      WBVar01096121
      WBVar01096122
      WBVar01096123
      WBVar00062536
      WBVar01096124
      WBVar01096125
      WBVar01096126
      WBVar02121907
      WBVar00062541
      WBVar01096127
      WBVar01096128
      WBVar00062546
      WBVar01992167
      WBVar00062551
      WBVar01992168
      WBVar01488686
      WBVar01992169
      WBVar01992170
      WBVar00062556
      WBVar02123941
      WBVar00062561
      WBVar02122472
      WBVar01977716
      WBVar01977717
      WBVar00062566
      WBVar01977718
      WBVar01875748
      WBVar00305841
      WBVar01875749
      WBVar01875750
      WBVar01875751
      WBVar01875752
      WBVar01499566
      WBVar01925345
      WBVar02123423
      WBVar02062875
      WBVar02073486
      WBVar01498314
      WBVar00234582
      WBVar00486544
      WBVar00486545
      WBVar00486546
      WBVar00486547
      WBVar00486548
      WBVar00486549
      WBVar00486550
      WBVar01499446
      WBVar02120529
      WBVar00486551
      WBVar00486552
      WBVar00486553
      WBVar00486554
      WBVar00486555
      WBVar00224771
      WBVar00224772
      WBVar02120721
      WBVar01522524
      WBVar01522525
      WBVar01638710
      WBVar01522526
      WBVar01638711
      WBVar01522527
      WBVar01522528
      WBVar01638712
      WBVar01638713
      WBVar01522529
      WBVar01522530
      WBVar01638714
      WBVar01638715
      WBVar01638716
      WBVar01498549
      WBVar01638717
      WBVar01638718
      WBVar02121483
      WBVar01499299
      WBVar01096092
      WBVar01096093
      WBVar01096094
      WBVar01096095
      WBVar01096096
      WBVar01096097
      WBVar01096098
      WBVar01096099
      WBVar01096100
      WBVar01096101
      WBVar01096102
      WBVar01597194
      WBVar01096103
      WBVar01597195
      WBVar01096104
      WBVar01597196
      WBVar01096105
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (114)
    Paralog (44)
    Structured_description: Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Keshan disease; glucose metabolism disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C8 (cytochrome P450 family 2 subfamily C member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (46)
  Molecular_info: Corresponding_CDS: Y17D7A.4
    Corresponding_CDS_history: Y17D7A.4:wp106
    Corresponding_transcript: Y17D7A.4.1
    Other_sequence (20)
    Associated_feature: WBsf982076
      WBsf1003019
      WBsf1021557
  Experimental_info: RNAi_result: WBRNAi00036657 Inferred_automatically: RNAi_primary
      WBRNAi00092667 Inferred_automatically: RNAi_primary
      WBRNAi00055560 Inferred_automatically: RNAi_primary
      WBRNAi00095077 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021931
      Expr1159061
      Expr2010722
      Expr2028960
    Microarray_results (15)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045774:clk-1_upregulated_CoQ10_dependent
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055137:S.maltophilia_downregulated
      WBPaper00055354:Allantoin_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00059605:mut-16(pk710)_downregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060399:CoCl2_6hr_downregulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L1
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061357:mett-10(ok2204)_upregulated_OP50
      WBPaper00061390:N2_ascarosides_downregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062056:lin-36(we36)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065841:15_0
      WBPaper00065849:ursolic-acid_regulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:Cisplatin_upregulated_tetraploid
      WBPaper00066118:cyclobutrifluram_downregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041609:hpl-1_hpl-2_downregulated
      WBPaper00041939:control_vs_EtBr-exposed_3h
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (35)
  Map_info: Map: V Position: 18.0657 Error: 0.02692
    Positive: Positive_clone: Y17D7A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene