WBGene00004035 | SMap | S_parent | Sequence | Y73F8A |
| Identity | Version | 1 |
| | Name | CGC_name | pkd-2 | Person_evidence | WBPerson625 |
| | | Sequence_name | Y73F8A.1 |
| | | Molecular_name | Y73F8A.1 |
| | | | Y73F8A.1.1 |
| | | | CE38663 |
| | | Other_name | pdk-2 |
| | | | CELE_Y73F8A.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | pkd-2 |
| | DB_info | Database | AceView | gene | 4P994 |
| | | | WormQTL | gene | WBGene00004035 |
| | | | WormFlux | gene | WBGene00004035 |
| | | | OMIM | disease | 613095 |
| | | | | gene | 173910 |
| | | | NDB | locus_tag | CELE_Y73F8A.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004035|UniProtKB=Q9U1S7 |
| | | | | family | PTHR10877 |
| | | | NCBI | gene | 178424 |
| | | | RefSeq | protein | NM_070437.5 |
| | | | SwissProt | UniProtAcc | Q9U1S7 |
| | | | UniProt_GCRP | UniProtAcc | Q9U1S7 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pkd |
| | Allele | WBVar00249018 | Inferred_automatically | From strain object: PS3398 |
| | | | | From strain object: PT8 |
| | | WBVar01860072 |
| | | WBVar01904577 |
| | | WBVar01904578 |
| | | WBVar01904579 |
| | | WBVar01904580 |
| | | WBVar01904581 |
| | | WBVar01499527 |
| | | WBVar02069873 |
| | | WBVar02069874 |
| | | WBVar02022109 |
| | | WBVar02022110 |
| | | WBVar00442856 |
| | | WBVar00442857 |
| | | WBVar00442858 |
| | | WBVar00442859 |
| | | WBVar01498996 |
| | | WBVar00442860 |
| | | WBVar00442861 |
| | | WBVar00442862 |
| | | WBVar00442863 |
| | | WBVar00442864 |
| | | WBVar00442865 |
| | | WBVar00442866 |
| | | WBVar00442867 |
| | | WBVar00442868 |
| | | WBVar00442869 |
| | | WBVar01499925 |
| | | WBVar00442870 |
| | | WBVar00442871 |
| | | WBVar01498824 |
| | | WBVar00442872 |
| | | WBVar00442873 |
| | | WBVar00442874 |
| | | WBVar00963961 |
| | | WBVar00442875 |
| | | WBVar00442876 |
| | | WBVar00963962 |
| | | WBVar00442877 |
| | | WBVar00963963 |
| | | WBVar00963964 |
| | | WBVar02056033 |
| | | WBVar00963965 |
| | | WBVar01968794 |
| | | WBVar01968795 |
| | | WBVar00963966 |
| | | WBVar01968796 |
| | | WBVar00963967 |
| | | WBVar01968797 |
| | | WBVar00963968 |
| | | WBVar00963969 |
| | | WBVar00963970 |
| | | WBVar00963971 |
| | | WBVar00963972 |
| | | WBVar00963973 |
| | | WBVar02047303 |
| | | WBVar00963974 |
| | | WBVar00963975 |
| | | WBVar00963976 |
| | | WBVar00963977 |
| | | WBVar00963978 |
| | | WBVar00963979 |
| | | WBVar00963980 |
| | | WBVar00963981 |
| | | WBVar00963982 |
| | | WBVar00963983 |
| | | WBVar00963984 |
| | | WBVar01798033 |
| | | WBVar02051026 |
| | | WBVar00963985 |
| | | WBVar00963986 |
| | | WBVar00963987 |
| | | WBVar00963988 |
| | | WBVar00963989 |
| | | WBVar00963990 |
| | | WBVar00963991 |
| | | WBVar00963992 |
| | | WBVar00963993 |
| | | WBVar00963994 |
| | | WBVar00963995 |
| | | WBVar00963996 |
| | | WBVar00963997 |
| | | WBVar00963998 |
| | | WBVar00963999 |
| | | WBVar00964000 |
| | | WBVar00964001 |
| | | WBVar00964002 |
| | | WBVar00964003 |
| | | WBVar00964004 |
| | | WBVar01498687 |
| | | WBVar00964005 |
| | | WBVar00964006 |
| | | WBVar00964007 |
| | | WBVar01733205 |
| | | WBVar01733206 |
| | | WBVar01733207 |
| | | WBVar02042888 |
| | | WBVar01733208 |
| | | WBVar02148641 |
| | | WBVar01733209 |
| | | WBVar02148338 |
| | | WBVar01733210 |
| | | WBVar01482884 |
| | | WBVar01733211 |
| | | WBVar01482885 |
| | | WBVar01733212 |
| | | WBVar01733213 |
| | | WBVar01733214 |
| | | WBVar01733215 |
| | | WBVar01733216 |
| | | WBVar01733217 |
| | | WBVar01847639 |
| | | WBVar01847640 |
| | | WBVar00196628 |
| | | WBVar00196629 |
| | | WBVar00196630 |
| | | WBVar00196631 |
| | | WBVar00196632 |
| | | WBVar00196633 |
| | | WBVar00196634 |
| | | WBVar00196635 |
| | | WBVar00196636 |
| | | WBVar00196637 |
| | | WBVar01806575 |
| | | WBVar01806576 |
| | | WBVar01806577 |
| | | WBVar01498930 |
| | | WBVar01498931 |
| | | WBVar00577110 |
| | | WBVar00577112 |
| | | WBVar00577113 |
| | | WBVar01455939 |
| | | WBVar01500245 |
| | | WBVar01499697 |
| | Strain | WBStrain00026468 |
| | | WBStrain00030885 |
| | | WBStrain00031062 |
| | | WBStrain00031013 |
| | RNASeq_FPKM (74) |
| | GO_annotation (66) |
| | Ortholog (57) |
| | Paralog | WBGene00003058 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | pkd-2 encodes a TRPP cation channel orthologous to human PKD2; pkd-2 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with lov-1; PKD-2 is expressed in the cilia of three types of male-specific sensory neurons; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron. | Paper_evidence | WBPaper00003680 |
| | | | | | WBPaper00004854 |
| | | | | | WBPaper00006247 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 12 Aug 2011 00:00:00 |
| | | Automated_description | Enables calcium channel activity. Involved in calcium ion transport; response to hermaphrodite contact; and vulval location. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and plasma membrane bounded cell projection. Expressed in CEM; nerve ring; neurons; and ray. Used to study autosomal dominant polycystic kidney disease. Human ortholog(s) of this gene implicated in intracranial aneurysm; polycystic kidney disease 2; and retinal degeneration. Is an ortholog of human PKD2 (polycystin 2, transient receptor potential cation channel) and PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00003680 |
| | | | | | WBPaper00004854 |
| | | | | Accession_evidence | OMIM | 613095 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 30 Apr 2018 00:00:00 |
| | Potential_model | DOID:0080322 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) |
| | | DOID:898 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) |
| | | DOID:0110859 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) |
| | | DOID:10941 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) |
| | | DOID:8466 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) |
| | Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00038373 |
| | | | | Accession_evidence | OMIM | 613095 |
| | | | | | | 173910 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Jan 2012 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000033 |
| Models_disease_asserted | WBDOannot00000514 |
| Molecular_info | Corresponding_CDS | Y73F8A.1 |
| | Corresponding_CDS_history | Y73F8A.1:wp90 |
| | | Y73F8A.1:wp143 |
| | Corresponding_transcript | Y73F8A.1.1 |
| | Other_sequence | CRC10242_1 |
| | | CR05211 |
| | | FK801188.1 |
| | | JI174536.1 |
| | Associated_feature | WBsf998698 |
| | | WBsf998699 |
| | | WBsf1018743 |
| | | WBsf1018744 |
| | | WBsf1018745 |
| | | WBsf1018746 |
| | | WBsf231243 |
| Experimental_info | RNAi_result | WBRNAi00066584 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000585 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00021407 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00021408 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00058373 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00112685 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00037811 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (17) |
| | Drives_construct (54) |
| | Construct_product (11) |
| | Antibody | WBAntibody00000407 |
| | | WBAntibody00002558 |
| | | WBAntibody00002633 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044743:wdr-23_neuron_upregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1 |
| | | WBPaper00050231:male_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053402:cco-1(RNAi)_upregulated |
| | | WBPaper00053402:his-3(RNAi)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055648:male-CEM-neurons_expressed |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L4 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060921:tbh-1(ok1196)_downregulated |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:ckr-1-T09B9.3 |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061753:csr-1(tor159)_downregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062491:sma-3(wk30)_downregulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00065746:eat-2(ad1113)_upregulated |
| | | cgc4489_group_14 |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041939:control_vs_UVC-exposed_24h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | [cgc6390]:male_soma-enriched |
| | Interaction (66) |
| | WBProcess | WBbiopr:00000012 |
| Map_info | Map | IV | Position | 13.0445 |
| | Positive | Positive_clone | Y73F8A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4982 |
| | Pseudo_map_position |
| Reference (156) |
| Remark | The use of the name pdk-2 for this gene was due to a typo in the original paper [krb 020128] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| | [140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. |
| Method | Gene |