WormBase Tree Display for Gene: WBGene00003158

WBGene00003158 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: mcm-6 Person_evidence: WBPerson1160
      Sequence_name: ZK632.1
      Molecular_name: ZK632.1a
        ZK632.1a.1
        CE00415
        ZK632.1b
        CE38018
        ZK632.1b.1
      Other_name: 3J887 Accession_evidence: EMBL AF326940
        CELE_ZK632.1 Accession_evidence: NDB BX284603
      Public_name: mcm-6
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mcm
    Allele: WBVar01500260
      WBVar01267289
      WBVar00406054
      WBVar00259308
      WBVar00406055
      WBVar00406056
      WBVar00406057
      WBVar00406058
      WBVar00406059
      WBVar00406060
      WBVar00406061
      WBVar00406062
      WBVar00406063
      WBVar00852571
      WBVar00852572
      WBVar00852573
      WBVar00852574
      WBVar00852575
      WBVar00852576
      WBVar00598646
      WBVar00852577
      WBVar00852578
      WBVar00598647
      WBVar00852579
      WBVar00598648
      WBVar01499774
      WBVar00852580
      WBVar00598649
      WBVar00852581
      WBVar00852582
      WBVar01567200
      WBVar00852583
      WBVar00852584
      WBVar01567201
      WBVar00852585
      WBVar00852586
      WBVar00852587
      WBVar01474377
      WBVar00852588
      WBVar00852589
      WBVar00852590
      WBVar00852591
      WBVar00852592
      WBVar00852593
      WBVar00852594
      WBVar00852595
      WBVar00852596
      WBVar00852597
      WBVar00852598
      WBVar00852599
      WBVar00178157
      WBVar01629525
      WBVar00100953
    RNASeq_FPKM (74)
    GO_annotation (28)
    Contained_in_operon: CEOP3624
    Ortholog (40)
    Paralog: WBGene00003154 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003155 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003156 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003157 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003159 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mcm-6 encodes a protein that has similarity to human DNA replication licensing factor MCM6 and affects embryonic viability. Paper_evidence: WBPaper00005599
            WBPaper00005654
            WBPaper00006395
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to be located in nucleus. Predicted to be part of MCM complex. Is an ortholog of human MCM6 (minichromosome maintenance complex component 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK632.1a
      ZK632.1b
    Corresponding_transcript: ZK632.1a.1
      ZK632.1b.1
    Other_sequence (56)
    Associated_feature: WBsf645517
      WBsf659452
      WBsf993806
      WBsf225628
  Experimental_info: RNAi_result (24)
    Expr_pattern: Expr1017019
      Expr1031493
      Expr1162982
      Expr2013453
      Expr2031687
    Drives_construct: WBCnstr00036211
    Construct_product: WBCnstr00036211
    Antibody: WBAntibody00002987
    Microarray_results (23)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044037:eat-2_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046499:AMPK_regulated
      WBPaper00046795:starvation_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058948:PA14_upregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Neuroblast_AIZ_FLP_RMG
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:pcn-1-cyb-3_17196
      WBPaper00062056:efl-1(se1)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_downregulated_N2_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065841:11_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_2
      cgc4489_group_2
      WBPaper00025032:cluster_87
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_A
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (216)
  Map_info: Map: III Position: 1.07313 Error: 0.002573
    Positive: Positive_clone: ZK632 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Sequence connection from [Kim SK]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene