WormBase Tree Display for Gene: WBGene00003150

WBGene00003150 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: mbk-2 Person_evidence: WBPerson1138
      Sequence_name: F49E11.1
      Molecular_name (42)
      Other_name: CELE_F49E11.1 Accession_evidence: NDB BX284604
      Public_name: mbk-2
    DB_info: Database: AceView gene 4N799
        WormQTL gene WBGene00003150
        SignaLink protein WBGene00003150
        WormFlux gene WBGene00003150
        OMIM disease 190685
            614104
          gene 600855
        NDB locus_tag CELE_F49E11.1
        Panther gene CAEEL|WormBase=WBGene00003150|UniProtKB=Q9XTF3
          family PTHR24058
        NCBI gene 178250
        RefSeq protein (14)
        KEGG KEGG_id 2.7.12.1
        NemaPath KEGG_id 2.7.12.1
        SwissProt UniProtAcc Q9XTF3
        TrEMBL UniProtAcc A0A061ACK4
            A0A061AJ20
            A0A061ACN3
            A0A061ADU8
            A0A061AKR6
            A0A061ACN7
        UniProt_GCRP UniProtAcc Q9XTF3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mbk
    Allele: WBVar02141357
      WBVar02141343
      WBVar02141358
      WBVar00951758
      WBVar01454825
      WBVar01944909
      WBVar01549083
      WBVar01454826
      WBVar01944910
      WBVar01549084
      WBVar00951759
      WBVar00951760
      WBVar01549085
      WBVar01944911
      WBVar01454827
      WBVar01549086
      WBVar00951761
      WBVar01454828
      WBVar01944912
      WBVar01944913
      WBVar01454830
      WBVar01549087
      WBVar00951762
      WBVar01549088
      WBVar01944914
      WBVar01454831
      WBVar00951763
      WBVar00951764
      WBVar01454832
      WBVar01944915
      WBVar01549089
      WBVar01549090
      WBVar00951765
      WBVar01944916
      WBVar01549091
      WBVar00262417
      WBVar01944917
      WBVar00951766
      WBVar00951767
      WBVar00951768
      WBVar01500079
      WBVar00951769
      WBVar00951770
      WBVar00951771
      WBVar00951772
      WBVar00951773
      WBVar01846982
      WBVar00951774
      WBVar00951775
      WBVar00951776
      WBVar01804433
      WBVar00951777
      WBVar01804434
      WBVar00951778
      WBVar00951779
      WBVar01804435
      WBVar00951780
      WBVar01804436
      WBVar00951781
      WBVar01804437
      WBVar00193011
      WBVar00951782
      WBVar01804438
      WBVar00193012
      WBVar01804439
      WBVar00193013
      WBVar00951783
      WBVar00193014
      WBVar01804440
      WBVar00951784
      WBVar00193015
      WBVar01804441
      WBVar00951785
      WBVar00193016
      WBVar00951786
      WBVar01804442
      WBVar00951787
      WBVar01967296
      WBVar01804443
      WBVar00193017
      WBVar00951788
      WBVar01804444
      WBVar00193018
      WBVar01967297
      WBVar01804445
      WBVar00951789
      WBVar01967298
      WBVar00193019
      WBVar02008367
      WBVar01804446
      WBVar01967299
      WBVar00951790
      WBVar01498996
      WBVar00193020
      WBVar02008368
      WBVar00193021
      WBVar01804447
      WBVar00951791
      WBVar01967300
      WBVar00193022
      WBVar01804448
      WBVar00951792
      WBVar02049879
      WBVar01967301
      WBVar00951793
      WBVar01804449
      WBVar00193023
      WBVar01967302
      WBVar02049880
      WBVar01494767
      WBVar01967303
      WBVar00951794
      WBVar00193024
      WBVar01967304
      WBVar00951795
      WBVar00193025
      WBVar00193026
      WBVar00315038
      WBVar00951796
      WBVar00951797
      WBVar00315039
      WBVar00193027
      WBVar00951798
      WBVar00193028
      WBVar00193029
      WBVar00951799
      WBVar01499925
      WBVar00951800
      WBVar00193030
      WBVar00193031
      WBVar00951801
      WBVar00951802
      WBVar00193032
      WBVar00951803
      WBVar00193033
      WBVar00951804
      WBVar00193034
      WBVar00193035
      WBVar00951805
      WBVar00951806
      WBVar00193036
      WBVar00951807
      WBVar00193037
      WBVar00951808
      WBVar00193038
      WBVar00951809
      WBVar00193039
      WBVar00193040
      WBVar00951810
      WBVar00951811
      WBVar00193041
      WBVar00270842
      WBVar00951812
      WBVar00951813
      WBVar00270843
      WBVar00951814
      WBVar00270844
      WBVar01491292
      WBVar00951815
      WBVar00270845
      WBVar00270847
      WBVar00951816
      WBVar02150355
      WBVar00951817
      WBVar00951818
      WBVar02125788
      WBVar00951819
      WBVar02125789
      WBVar00951820
      WBVar02125790
      WBVar00951821
      WBVar02125791
      WBVar00951822
      WBVar00951823
      WBVar00951824
      WBVar00951825
      WBVar00951826
      WBVar00951827
      WBVar00951828
      WBVar00951829
      WBVar01796379
      WBVar00951830
      WBVar01796380
      WBVar00951831
      WBVar01796381
      WBVar00951832
      WBVar01516398
      WBVar00951833
      WBVar01796382
      WBVar01796383
      WBVar00951834
      WBVar00951835
      WBVar01796384
      WBVar00951836
      WBVar01796385
      WBVar01796386
      WBVar00951837
      WBVar00951838
      WBVar01796387
      WBVar01796388
      WBVar00951839
      WBVar01796389
      WBVar00951840
      WBVar00951841
      WBVar01818863
      WBVar00951842
      WBVar00951843
      WBVar00951844
      WBVar00951845
      WBVar00951846
      WBVar00951847
      WBVar00951848
      WBVar00951849
      WBVar02108358
      WBVar02042134
      WBVar00951850
      WBVar02151332
      WBVar00951851
      WBVar02042135
      WBVar00951852
      WBVar02042136
      WBVar00951853
      WBVar02042137
      WBVar00951854
      WBVar02042138
      WBVar00951855
      WBVar02134902
      WBVar02042139
      WBVar02042140
      WBVar00951856
      WBVar02134903
      WBVar00951857
      WBVar02042141
      WBVar00951858
      WBVar00951859
      WBVar00951860
      WBVar00951861
      WBVar00951862
      WBVar00951863
      WBVar00951864
      WBVar00951865
      WBVar00951866
      WBVar00951867
      WBVar00951868
      WBVar00239371
      WBVar00951869
      WBVar00951870
      WBVar00951871
      WBVar00951872
      WBVar00951873
      WBVar00090989
      WBVar00951874
      WBVar00438897
      WBVar00951875
      WBVar00951876
      WBVar00438898
      WBVar00951877
      WBVar00438899
      WBVar00438900
      WBVar00951878
      WBVar00438901
      WBVar00951879
      WBVar00438902
      WBVar00951880
      WBVar00951881
      WBVar01828145
      WBVar00438903
      WBVar00951882
      WBVar00438904
      WBVar00951883
      WBVar00438905
      WBVar00438906
      WBVar00951884
      WBVar00438907
      WBVar00951885
      WBVar00300089
      WBVar00438908
      WBVar00951886
      WBVar00438909
      WBVar00951887
      WBVar00438910
      WBVar02109133
      WBVar00951888
      WBVar00951889
      WBVar02109134
      WBVar00438911
      WBVar00438912
      WBVar00951890
      WBVar01482535
      WBVar00438913
      WBVar00951891
      WBVar00091008
      WBVar01482536
      WBVar01482537
      WBVar00951892
      WBVar00438914
      WBVar00951893
      WBVar00438915
      WBVar00951894
      WBVar00438916
      WBVar00951895
      WBVar00438917
      WBVar00438918
      WBVar00258131
      WBVar01710294
      WBVar00951896
      WBVar00438919
      WBVar00951897
      WBVar00951898
      WBVar00438920
      WBVar00951899
      WBVar00438921
      WBVar00438922
      WBVar02074296
      WBVar00438923
      WBVar00438924
      WBVar01731402
      WBVar00438925
      WBVar00438926
      WBVar00438927
      WBVar00438928
      WBVar00438929
      WBVar00438930
      WBVar00438931
      WBVar00438932
      WBVar01688343
      WBVar00438933
      WBVar01688344
      WBVar00438934
      WBVar00438935
      WBVar00574968
      WBVar00438936
      WBVar00574974
      WBVar00951730
      WBVar02031163
      WBVar00438937
      WBVar01786485
      WBVar00574979
      WBVar00951731
      WBVar00259991
      WBVar00951732
      WBVar00438938
      WBVar00574980
      WBVar00574981
      WBVar00951733
      WBVar00438939
      WBVar01499492
      WBVar00574983
      WBVar00438940
      WBVar00951734
      WBVar00574986
      WBVar00438941
      WBVar01499493
      WBVar00951735
      WBVar00275488
      WBVar00951736
      WBVar00438942
      WBVar00951737
      WBVar00438943
      WBVar00438944
      WBVar00951738
      WBVar00951739
      WBVar00438945
      WBVar00438946
      WBVar01549065
      WBVar02037394
      WBVar00951740
      WBVar00438947
      WBVar02037395
      WBVar01549066
      WBVar00951741
      WBVar00438948
      WBVar00951742
      WBVar01549067
      WBVar02037396
      WBVar01549068
      WBVar02037397
      WBVar00951743
      WBVar00438949
      WBVar01549069
      WBVar00951744
      WBVar02037398
      WBVar00438950
      WBVar00951745
      WBVar01549070
      WBVar00093399
      WBVar02037399
      WBVar00438951
      WBVar00438952
      WBVar01549071
      WBVar00951746
      WBVar02037400
      WBVar01772283
      WBVar00438953
      WBVar00951747
      WBVar01549072
      WBVar02037401
      WBVar01772284
      WBVar00438954
      WBVar01549073
      WBVar00951748
      WBVar00142799
      WBVar00951749
      WBVar01549074
      WBVar00951750
      WBVar01549075
      WBVar01549076
      WBVar01500245
      WBVar00951751
      WBVar01549077
      WBVar00951752
      WBVar00951753
      WBVar01549078
      WBVar01549079
      WBVar00951754
      WBVar00275539
      WBVar01549080
      WBVar00951755
      WBVar01944906
      WBVar00256702
      WBVar01944907
      WBVar00951756
      WBVar01549081
      WBVar01454823
      WBVar01944908
      WBVar01549082
      WBVar00951757
      WBVar00306883
      WBVar01454824
    Strain (30)
    RNASeq_FPKM (74)
    GO_annotation (67)
    Ortholog (42)
    Paralog: WBGene00001994 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003149 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016465 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00016464 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00006517 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013727 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00185089 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mbk-2 encodes one of two C. elegans members of the DYRK (dual-specificity Yak1-related kinase) family of proteins that includes S. cerevisiae Yak1 and the Drosophila minibrain and DYRK2 kinases; MBK-2 activity is required maternally for the oocyte-to-egg transition that occurs during the earliest stages of embryonic development; specifically, MBK-2 is required for: 1) posterior localization of the germ plasm components PIE-1, POS-1, and PGL-1, and 2) post-fertilization degradation of a subset of maternal proteins including the MEI-1 and MEI-2 meiosis-specific katanin subunits, the OMA-1 oocyte maturation factor, and residual PIE-1 that remains anteriorly localized after its normal posterior segregation; MBK-2 also primes the MEX-5 polarity protein for subsequent phosphorylation by the polo-like kinase PLK-1; genetic analyses suggest that, in regulating the segregation and degradation of maternal proteins, MBK-2 lies downstream of the initial embryonic polarity cues established by the PAR and MEX proteins; MBK-2 activity depends upon progression through the meiotic divisions and is positively regulated by CDK-1 and negatively regulated by EGG-3 and EGG-4/5; MBK-2 physically interacts with EGG-3 and EGG-4, suggesting that regulation by EGG-3 and EGG-4 is direct; MBK-2 is expressed uniformly in the cortex of oocytes and newly fertilized zygotes; in later stage zygotes, just prior to the second meiotic division, MBK-2 becomes localized to discrete cortical foci, and by the first mitosis it is found predominantly on centrosomes and chromosomes; MBK-2 is also associated with P granules in the germline blastomeres P2, P3, and P4. Paper_evidence: WBPaper00006085
            WBPaper00006352
            WBPaper00026970
            WBPaper00026975
            WBPaper00027607
            WBPaper00031434
            WBPaper00035427
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Mar 2011 00:00:00
      Automated_description: Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including P granule disassembly; asymmetric protein localization involved in cell fate determination; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cell cortex and intracellular non-membrane-bounded organelle. Expressed in several structures, including body wall musculature; embryonic cell; gonad; oocyte; and pharynx. Used to study Down syndrome. Is an ortholog of human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14250 Homo sapiens Paper_evidence: WBPaper00005756
          Accession_evidence: OMIM 190685
              614104
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
    Disease_relevance: Human DYRK1A gene encodes a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, which includes Drosophila minibrain, and is a conserved gene located in the Down Syndrome critical region (DSCR) of chromosome 21; Down syndrome is the most frequent chromosomal abnormality in human infants, where DYRK1A overexpression is observed, and is characterized by a set of facial and physical features, heart defects, abnormalities in the immune and endocrine systems, spatial memory defecits and difficulty in converting short-term to long-term memories; in elegans, the genes mbk-1 and mbk-2 have close homology with human DYRK1A and hpk-1 is more distantly related; while mutants deficient for mbk-1 seem to be normal, overexpression of mbk-1 causes behavioral defects in chemotaxis, acting in mature, fully differentiated neurons; however, this defect could be reversed by bringing back normal mbk-1 levels, which provided the first hint that DYRK1-induced defects could be reversed; mbk-2(pk1427) homozygous animals display 100% penetrant maternal-effect embryonic lethality, making it difficult to test redundant function with mbk-1. Homo sapiens Paper_evidence: WBPaper00005756
          Accession_evidence: OMIM 600855
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
  Models_disease_asserted: WBDOannot00000129
  Molecular_info: Corresponding_CDS (14)
    Corresponding_transcript (14)
    Other_sequence (53)
    Associated_feature (76)
  Experimental_info: RNAi_result (38)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000360
      WBCnstr00000362
      WBCnstr00011276
      WBCnstr00012087
    Construct_product: WBCnstr00000083
      WBCnstr00000084
      WBCnstr00000088
      WBCnstr00000362
      WBCnstr00000364
      WBCnstr00010903
      WBCnstr00011276
      WBCnstr00011667
      WBCnstr00012087
    Antibody: WBAntibody00001303
      WBAntibody00001304
    Microarray_results (61)
    Expression_cluster (155)
    Interaction (272)
  Map_info: Map: IV Position: 6.86808 Error: 0.065322
    Positive: Positive_clone: F49E11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4484
    Pseudo_map_position
  Reference (64)
  Remark: Sequence connection from [Raich WB]. 02/06/12 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene