WormBase Tree Display for Variation: WBVar00275213

WBVar00275213 Name: Public_name: x18
    Other_name: Y110A7A.3.1:c.110-1G>A
    HGVSg: CHROMOSOME_I:g.5142174G>A
  Sequence_details: SMap: S_parent: Sequence: Y110A7A
    Flanking_sequences: tcgccaaaaagaaaaactaaaaatatttca attacaataaactggtgcgaccggtcagtg
    Mapping_target: Y110A7A
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040032
      WBStrain00040929
    Laboratory: ZZ
    Status: Live
  Affects: Gene: WBGene00006797
    Transcript: Y110A7A.3.1 VEP_consequence: splice_acceptor_variant
        VEP_impact: HIGH
        HGVSc: Y110A7A.3.1:c.110-1G>A
        Intron_number: 2/11
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00024268
  Genetics: Interpolated_map_position: I -0.357566
    Mapping_data: In_2_point: 245
        246
      In_multi_point: 238
        973
        991
        2093
  Description: Phenotype: WBPhenotype:0000017 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 2mM aldicarb Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000421 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1mM levamisole Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: No backward motion in L1 larvae. Newly hatched larvae can barely move forward. Adults have a mild Unc defect where the mutants move forward in a slow decayed sine wave. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001289 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Animals are resistant to the acetylcholinesterase inhibitors trichlorfon and eserine. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1mM trichlorfon. 1mM eserine Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001578 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Animals are resistant to the cholinergic agonist carbachol. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1mM carbachol Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000315 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0000478 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Mutants tend to remain within the borders of bacterial lawns as does the wild-type. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001084 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Attraction to sodium chloride is normal (See methods). Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001414 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
  Reference: WBPaper00000484
    WBPaper00018321
  Method: Substitution_allele