WormBase Tree Display for Variation: WBVar00274912

WBVar00274912 Evidence: Paper_evidence: WBPaper00005583
  Name: Public_name: um3
    Other_name: T07A9.3.1:c.404+335_1024del
      T07A9.3.3:c.404+335_1024del
      T07A9.3.2:c.404+335_1024del
    HGVSg: CHROMOSOME_IV:g.406155_407412del
  Sequence_details: SMap: S_parent: Sequence: T07A9
    Flanking_sequences: aataataagtttattgctgacacttttcaa ttaaggtacaacaattttagcactaaacaa
    Mapping_target: T07A9
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023465
      WBStrain00023468
      WBStrain00055932
      WBStrain00055935
    Laboratory: KB
      JN
    Status: Live
  Affects: Gene: WBGene00002187
    Transcript: T07A9.3.3 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T07A9.3.3:c.404+335_1024del
        cDNA_position: ?-1036
        CDS_position: ?-1024
        Protein_position: ?-342
        Intron_number: 5-8/10
        Exon_number: 6-9/11
      T07A9.3.2 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T07A9.3.2:c.404+335_1024del
        cDNA_position: ?-1145
        CDS_position: ?-1024
        Protein_position: ?-342
        Intron_number: 6-9/11
        Exon_number: 7-10/12
      T07A9.3.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T07A9.3.1:c.404+335_1024del
        cDNA_position: ?-1111
        CDS_position: ?-1024
        Protein_position: ?-342
        Intron_number: 6-9/11
        Exon_number: 7-10/12
    Interactor (25)
  Genetics: Interpolated_map_position: IV -26.1355
    Mapping_data: In_multi_point: 4454
  Description: Phenotype (13)
    Phenotype_not_observed: WBPhenotype:0000081 Paper_evidence: WBPaper00049705
        Curator_confirmed: WBPerson34124
        Remark: reduced survival after prolonged L1 arrest Paper_evidence: WBPaper00049705
            Curator_confirmed: WBPerson34124
      WBPhenotype:0000306 Paper_evidence: WBPaper00043917
        Curator_confirmed: WBPerson2987
        Remark: "Next, we tested whether in a kgb-1 mutant paraquat triggered hsp-6::gfp induction is relieved, as we have observed using elt-2 RNAi. In line with our hypothesis, RNAi of afts-1 or pifk-1, both in the kgb-1(+) control strain and in the kgb-1(um3) mutant, still blocked the paraquat-triggered hsp-6::gfp induction (Figure 10A, 10B)." Paper_evidence: WBPaper00043917
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00002747 Paper_evidence: WBPaper00043917
              Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: zcIs13 [Phsp-6::GFP]; afts-1(RNAi) or pifk-1(RNAi) Paper_evidence: WBPaper00043917
              Curator_confirmed: WBPerson2987
  Reference: WBPaper00038321
    WBPaper00005583
    WBPaper00031869
    WBPaper00012507
    WBPaper00025272
    WBPaper00043917
    WBPaper00049705
    WBPaper00065802
    WBPaper00066032
    WBPaper00046151
  Remark: Deletion endpoints estimated from Fig. 2 in paper [krb 030609] Paper_evidence: WBPaper00005583
  Method: Deletion_allele