WormBase Tree Display for Variation: WBVar00266638

WBVar00266638 Evidence: Paper_evidence: WBPaper00004492
    Person_evidence: WBPerson46176
  Name: Public_name: u282
    Other_name: T14F9.5.1:c.241G>A
      CE33318:p.Glu81Lys
    HGVSg: CHROMOSOME_X:g.2229780C>T
  Sequence_details: SMap: S_parent: Sequence: T14F9
    Flanking_sequences: caacattcagcgtgttcattcttcggcgct ccgttcatttgcagcacttcttctcattcg
    Mapping_target: T14F9
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00035039
    Laboratory: TU
    Status: Live
  Affects: Gene: WBGene00003018
    Transcript: T14F9.5.1 (12)
    Interactor: WBInteraction000501653
      WBInteraction000501777
  Genetics: Interpolated_map_position: X -16.0465
    Mapping_data: In_multi_point: 2313
      In_pos_neg_data: 5448
        5459
        5465
  Description: Phenotype: WBPhenotype:0000316 Paper_evidence: WBPaper00001125
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: PLM is not observed in these mutants. Paper_evidence: WBPaper00001125
            Curator_confirmed: WBPerson712
          touch-insensitive in tail Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005490 PATO:0000460 Paper_evidence: WBPaper00001125
                Curator_confirmed: WBPerson712
      WBPhenotype:0000529 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: lack PLM, AVM, PVM neurons, hence touch-insensitive in tail Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005490 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
            WBbt:0003832 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
            WBbt:0004086 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0001333 Paper_evidence: WBPaper00001125
        Curator_confirmed: WBPerson712
        Remark: PLM is not observed in these mutants. Also a number of neurons are in unusual positions (immediately posterior to the pharynx and anterior to the anus). Paper_evidence: WBPaper00001125
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005490 PATO:0000460 Paper_evidence: WBPaper00001125
                Curator_confirmed: WBPerson712
      WBPhenotype:0001414 Paper_evidence: WBPaper00001125
        Curator_confirmed: WBPerson712
        Remark: Males cannot mate. Paper_evidence: WBPaper00001125
            Curator_confirmed: WBPerson712
      WBPhenotype:0001509 Paper_evidence: WBPaper00004492
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: loss of nearly all rays Paper_evidence: WBPaper00004492
            Curator_confirmed: WBPerson48
          stronger than e1926; 90% of males lack rays; also lack PLM, AVM, PVM neurons, hence touch-insensitive in tail Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000850 Paper_evidence: WBPaper00001125
        Curator_confirmed: WBPerson712
        Remark: Animals are sensitive to touch in the head. Paper_evidence: WBPaper00001125
            Curator_confirmed: WBPerson712
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00014772
    WBPaper00006052
    WBPaper00001125
    WBPaper00014514
    WBPaper00015464
    WBPaper00010912
    WBPaper00004492
    WBPaper00014063
    WBPaper00014229
    WBPaper00021037
  Remark: We sequenced the mutation in lin-32(u282). Miller and Portman, 2011 (PMID: 21917811) reported that u282 resulted in E(81)K, but the actual allele alteration is not listed in Wormbase. Person_evidence: WBPerson46176
      Curator_confirmed: WBPerson51134
    alt_det = g to a mut_det = E(81)K Person_evidence: WBPerson46176
      Curator_confirmed: WBPerson51134
    Variation information submitted by WBPerson46176 on 2023-08-9_19:27:01 via the Allele submission form.Submitted data refers to CDS sequence. Curator_confirmed: WBPerson51134
  Method: Substitution_allele