WormBase Tree Display for Variation: WBVar00252326

WBVar00252326 Name: Public_name: tm3713
    Other_name: F29B9.2c.1:c.534_943+1del
      F29B9.2b.1:c.438_847+1del
      F29B9.2a.1:c.477_886+1del
    HGVSg: CHROMOSOME_IV:g.4661635_4662209del
  Sequence_details: SMap: S_parent: Sequence: F29B9
    Flanking_sequences: ggagtcaaatcagaactacgtcagcaacgg taagttttttcatcgaatagcttgcaatta
    Mapping_target: F29B9
    Source_location: 7 CHROMOSOME_IV 4661634 4662210 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Deletion
    PCR_product: tm3713_external
      tm3713_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 3713
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00017920
    Transcript: F29B9.2c.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F29B9.2c.1:c.534_943+1del
        cDNA_position: 534-?
        CDS_position: 534-?
        Protein_position: 178-?
        Intron_number: 3-4/9
        Exon_number: 3-4/10
      F29B9.2b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F29B9.2b.1:c.438_847+1del
        cDNA_position: 456-?
        CDS_position: 438-?
        Protein_position: 146-?
        Intron_number: 4-5/11
        Exon_number: 4-5/12
      F29B9.2a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F29B9.2a.1:c.477_886+1del
        cDNA_position: 495-?
        CDS_position: 477-?
        Protein_position: 159-?
        Intron_number: 5-6/12
        Exon_number: 5-6/13
    Interactor: WBInteraction000521428
      WBInteraction000521429
  Isolation: Mutagen: TMP/UV
  Genetics: Map: IV
  Description: Phenotype: WBPhenotype:0002078 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: F29B9.2(tm3713) mutant animals showed an increase in global levels of H3K9me2 and H3K27me2, compared to wild-type animals. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0004024 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: F29B9.2(tm3713) mutant animals showed defects in body movement. Wild-type N2 animals moved by alternating dorsal and ventral flexions along the body length, producing a regular sinusoidal track on bacteria. In contrast to this, the track pattern left by tm3713 was irregular, with increased wavelength (distance between successive peaks of a wave) but unchanged amplitude of the wave. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
    Phenotype_not_observed: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as 'homozygous viable' by the National Bioresource Project of Japan. Comment to the NBP from Dr. A. Salcini: Mol Cell. 38, 165 (2010). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000634 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: Data not shown. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0000640 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: Data not shown. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0000680 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: Data not shown. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0000845 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: Data not shown. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0001232 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: Data not shown. Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0002168 Paper_evidence: WBPaper00045092
        Curator_confirmed: WBPerson712
      WBPhenotype:0002535 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
        Remark: Dye filling in sensory neurons normal (data not shown). Paper_evidence: WBPaper00036110
            Curator_confirmed: WBPerson557
      WBPhenotype:0004022 Paper_evidence: WBPaper00036110
        Curator_confirmed: WBPerson557
  Disease_info: Models_disease: DOID:0060309
    Models_disease_in_annotation: WBDOannot00000447
  Reference: WBPaper00036110
    WBPaper00045092
  Remark: 15767/15768-16342/16343 (575 bp deletion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele