WormBase Tree Display for Gene: WBGene00017920
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| WBGene00017920 | SMap | S_parent | Sequence | F29B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | jmjd-1.2 | Person_evidence | WBPerson260 | |||||
| Sequence_name | F29B9.2 | ||||||||
| Molecular_name | F29B9.2a | ||||||||
| F29B9.2a.1 | |||||||||
| CE09781 | |||||||||
| F29B9.2b | |||||||||
| CE27145 | |||||||||
| F29B9.2c | |||||||||
| CE48643 | |||||||||
| F29B9.2b.1 | |||||||||
| F29B9.2c.1 | |||||||||
| Other_name | CeKDM7A | Paper_evidence | WBPaper00040011 | ||||||
| CELE_F29B9.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | jmjd-1.2 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Sep 2011 16:40:15 | WBPerson2970 | Name_change | CGC_name | jmjd-1.2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | jmjd | ||||||||
| Allele (59) | |||||||||
| Strain | WBStrain00037581 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Contained_in_operon | CEOP4136 | ||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00005013 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020821 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | jmjd-1.2 encodes a PHD and JmjC domain-containing histone demethylase that is homologous to human PHF8, mutations in which are associated with mild X-linked mental retardation (XLMR) and cleft/lip palate; JMJD-1.2 exhibits H3K9me2 and H3K27me2 demethylase activity in vitro and loss-of-function mutations in jmjd-1.2 result in increased levels of H3K9me2 and H3K27me2 in protein lysates from mutant animals; jmjd-1.2 mutant animals also exhibit locomotion defects with increased wavelength, but normal amplitude, of sinusoidal movement; a jmjd-1.2::GFP fusion protein is strongly expressed in neurons where it localizes to the nucleus; fainter expression is also seen in muscle, intestine, and hypodermal cells; jmjd-1.2 expression in neurons is sufficient to rescue the locomotion defects. | Paper_evidence | WBPaper00036110 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Apr 2010 00:00:00 | ||||||||
| Automated_description | Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Expressed in several structures, including germ cell; hypodermis; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma; prostate cancer; and syndromic X-linked intellectual disability Siderius type. Is an ortholog of human KDM7A (lysine demethylase 7A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060309 | Homo sapiens | Paper_evidence | WBPaper00050709 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Nov 2017 00:00:00 | ||||||||
| Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20672) | |||||
| DOID:1909 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:22224) | ||||||
| DOID:0060812 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20672) | ||||||
| Models_disease_asserted | WBDOannot00000447 | ||||||||
| Molecular_info | Corresponding_CDS | F29B9.2a | |||||||
| F29B9.2b | |||||||||
| F29B9.2c | |||||||||
| Corresponding_transcript | F29B9.2a.1 | ||||||||
| F29B9.2b.1 | |||||||||
| F29B9.2c.1 | |||||||||
| Other_sequence (65) | |||||||||
| Associated_feature | WBsf047593 | ||||||||
| WBsf047594 | |||||||||
| WBsf645943 | |||||||||
| WBsf977089 | |||||||||
| WBsf996358 | |||||||||
| WBsf228223 | |||||||||
| WBsf228224 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr13259 | ||||||||
| Expr13525 | |||||||||
| Expr1021912 | |||||||||
| Expr1037705 | |||||||||
| Expr1149803 | |||||||||
| Expr2012886 | |||||||||
| Expr2031120 | |||||||||
| Drives_construct | WBCnstr00026915 | ||||||||
| Construct_product | WBCnstr00026915 | ||||||||
| Regulate_expr_cluster | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated | ||||||||
| WBPaper00049545:rgef-1pjmjd-1.2(+)_downregulated | |||||||||
| WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated | |||||||||
| WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated | |||||||||
| WBPaper00050709:jmjd-1.2(tm3713)_regulated | |||||||||
| WBPaper00062156:jmjd-1.2(zr1010)_downregulated | |||||||||
| WBPaper00062156:jmjd-1.2(zr1010)_upregulated | |||||||||
| WBPaper00066083:hlh-17p-jmjd-1.2_downregulated | |||||||||
| WBPaper00066083:hlh-17p-jmjd-1.2_upregulated | |||||||||
| Antibody | WBAntibody00002197 | ||||||||
| WBAntibody00002746 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | IV | Position | 0.6425 | Error | 0.013666 | |||
| Positive | Positive_clone | F29B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
