WormBase Tree Display for Variation: WBVar00250282

WBVar00250282 Name: Public_name: tm1276
    Other_name: F02E9.4a.1:c.676-101_889del
      F02E9.4b.1:c.676-101_889del
    HGVSg: CHROMOSOME_I:g.8417794_8418108del
  Sequence_details: SMap: S_parent: Sequence: F02E9
    Flanking_sequences: ttcaaatattagatgatgatattttatcaa aaagtactttctcatctgatgtacccgttt
    Mapping_target: F02E9
    Source_location: 7 CHROMOSOME_I 8417793 8418109 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Deletion
    PCR_product: tm1276_external
      tm1276_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023475
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 1276
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00004117
    Transcript: F02E9.4b.1 VEP_consequence: splice_acceptor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F02E9.4b.1:c.676-101_889del
        cDNA_position: ?-890
        CDS_position: ?-889
        Protein_position: ?-297
        Intron_number: 2/21
        Exon_number: 3/22
      F02E9.4a.1 VEP_consequence: splice_acceptor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F02E9.4a.1:c.676-101_889del
        cDNA_position: ?-905
        CDS_position: ?-889
        Protein_position: ?-297
        Intron_number: 2/21
        Exon_number: 3/22
  Isolation: Mutagen: TMP/UV
  Genetics: Map: I
  Description: Phenotype: WBPhenotype:0000141 Paper_evidence: WBPaper00055902
        Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
      WBPhenotype:0000154 Paper_evidence: WBPaper00055902
        Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
          WBPerson38493
        Remark: Comment from Dr. J. Satterlee to the National Bioresource Project of Japan: reduced brood size, more severe at 25 degree. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
          Fig 2 a &b Paper_evidence: WBPaper00055902
            Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
      WBPhenotype:0000229 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
        Remark: Comment from Dr. K.L. Chow to the National Bioresource Project of Japan: small animal. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
            Laboratory_evidence: KC
      WBPhenotype:0000297 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
        Remark: Comment from Dr. K.L. Chow to the National Bioresource Project of Japan: Ray patterning defects (fusion). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
            Laboratory_evidence: KC
      WBPhenotype:0000697 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
        Remark: Comment from Drs. J. Satterlee and Dr. K.L. Chow to the National Bioresource Project of Japan: protruding vulva. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
            Laboratory_evidence: KC
      WBPhenotype:0001171 Paper_evidence: WBPaper00055902
        Curator_confirmed: WBPerson38493
        Remark: Fig. 1a lifespan of 10 and 14 days, respectively, as compared to 19 and 28 days in him-5 hermaphrodite worms Paper_evidence: WBPaper00055902
            Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
      WBPhenotype:0001212 Paper_evidence: WBPaper00055902
        Curator_confirmed: WBPerson38493
        EQ_annotations: Anatomy_term: WBbt:0005755 PATO:0001362 Paper_evidence: WBPaper00055902
                Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
      WBPhenotype:0001575 Paper_evidence: WBPaper00055902
        Curator_confirmed: WBPerson38493
        EQ_annotations: Molecule_affected: WBMol:00001405 PATO:0001997 Paper_evidence: WBPaper00055902
                Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
      WBPhenotype:0002263 Paper_evidence: WBPaper00055902
        Curator_confirmed: WBPerson38493
        EQ_annotations: GO_term: GO:0042391 PATO:0000460 Paper_evidence: WBPaper00055902
                Curator_confirmed: WBPerson38493
            GO:0005739 PATO:0000460 Paper_evidence: WBPaper00055902
                Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
    Phenotype_not_observed: WBPhenotype:0000020 Paper_evidence: WBPaper00055902
        Curator_confirmed: WBPerson38493
        EQ_annotations: GO_term: GO:0043050 PATO:0000460 Paper_evidence: WBPaper00055902
                Curator_confirmed: WBPerson38493
        Phenotype_assay: Strain: WBStrain00023475 Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
          Genotype: him-5(e1490) Paper_evidence: WBPaper00055902
              Curator_confirmed: WBPerson38493
      WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as homozygous viable by the National Bioresource Project of Japan. Comments to the NBP from Dr. M. Han: suppress synMuv; Dr. M. Peter: does not suppress par-2 (RNAi). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
              TA
              MH
      WBPhenotype:0000697 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment to NBP from Dr. J. Ahringer: non-Pvl. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: JA
  Reference: WBPaper00055902
  Remark: 13398/13399-13713/13714 (315 bp deletion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele