WormBase Tree Display for Variation: WBVar00250125

WBVar00250125 Name: Public_name: tm1108
    Other_name: T12E12.4a.2:c.576_954delinsCTCCAGCGAACCAGGATT
      T12E12.4b.2:c.576_954delinsCTCCAGCGAACCAGGATT
      CE30173:p.Phe193SerfsTer27
      CE30172:p.Phe193SerfsTer27
      T12E12.4a.1:c.576_954delinsCTCCAGCGAACCAGGATT
      T12E12.4b.1:c.576_954delinsCTCCAGCGAACCAGGATT
    HGVSg: CHROMOSOME_IV:g.5539115_5539538delinsCTCCAGCGAACCAGGATT
  Sequence_details: SMap: S_parent: Sequence: T12E12
    Flanking_sequences: cattctggctgtaactccagcgaaccagga tcggatcttgttgcattcggtgaaccagtt
    Mapping_target: T12E12
    Source_location: 7 CHROMOSOME_IV 5539114 5539539 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: CTCCAGCGAACCAGGATT
      Deletion
    PCR_product: tm1108_external
      tm1108_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005196
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 1108
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00001093
    Transcript: T12E12.4b.2 (11)
      T12E12.4a.1 (11)
      T12E12.4b.1 (11)
      T12E12.4a.2 (11)
    Interactor: WBInteraction000501344
      WBInteraction000548956
      WBInteraction000571769
  Isolation: Mutagen: TMP/UV
  Genetics: Map: IV
  Description: Phenotype (16)
    Phenotype_not_observed: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from Dr. D. Xue to the National Bioresource Project of Japan: slow growth but not lethal or sterile. Originally classified as lethal OR sterile by the National Bioresource Project of Japan. Mol Cell, 31, 586 (2008). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0000140 Paper_evidence: WBPaper00041209
        Curator_confirmed: WBPerson712
        Remark: did not significantly exacerbate L3 arrest at any time point Paper_evidence: WBPaper00041209
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003513 Paper_evidence: WBPaper00041209
              Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000035 PATO:0000460 Paper_evidence: WBPaper00041209
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: serial ultraviolet C radiation(UVC) exposure (10 J/m2) Paper_evidence: WBPaper00041209
              Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from Dr. A. van der Bliek to the National Bioresource Project of Japan: Normal locomotion. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0001983 Paper_evidence: WBPaper00056369
        Curator_confirmed: WBPerson9270
  Disease_info: Models_disease: DOID:14330
    Models_disease_in_annotation: WBDOannot00000741
  Reference: WBPaper00038057
    WBPaper00041209
    WBPaper00033026
    WBPaper00035144
    WBPaper00044205
    WBPaper00047030
    WBPaper00056369
    WBPaper00064979
    WBPaper00065803
  Remark: 1053/1054-CTCCAGCGAACCAGGATT-1477/1478 (425 bp deletion + 18 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele