WormBase Tree Display for Variation: WBVar00248951
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| WBVar00248951 | Evidence | Paper_evidence | WBPaper00014894 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Public_name | sy254 | |||||||
| Sequence_details | Mapping_target | C37F5 | |||||||
| SeqStatus | Pending_curation | ||||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00027299 | ||||||||
| WBStrain00027326 | |||||||||
| Laboratory | PS | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00002990 | |||||||
| Interactor | WBInteraction000502206 | ||||||||
| Description | Phenotype | WBPhenotype:0000700 | Paper_evidence | WBPaper00002125 | |||||
| Curator_confirmed | WBPerson625 | ||||||||
| Remark | multivulva | Paper_evidence | WBPaper00002125 | ||||||
| Curator_confirmed | WBPerson625 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006748 | PATO:0000460 | Paper_evidence | WBPaper00002125 | ||||
| Curator_confirmed | WBPerson625 | ||||||||
| WBPhenotype:0000961 | Paper_evidence | WBPaper00004481 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "Similar to lin-15 mutants, lin-1 loss-of-function mutants have all VPCs adopting vulval fates, and the AC is closest to P6.p, which always becomes 1°. We found that the zmp-1::GFP expression pattern in P6.pxxx was abnormal in 18 of 23 animals examined (Table 5), suggesting that lin-1 is involved in 1° lineage patterning." | Paper_evidence | WBPaper00004481 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| "Simply activating RAS signaling by let-23(gf) can partially rescue the 1° patterning defect caused by the absence of the AC (Table 5), suggesting that the inner and outer 1° VPC descendants can differentiate from one another independent of the AC. Furthermore, when the AC was ablated, RAS signaling disrupted by heat shock induced RAS(dn) after the induction of VPC fates, or lin-1 mutated, the 1° VPC descendants expressed zmp-1::GFP in a variable fashion (Tables 1D, 4, 5). However, a careful examination of the pattern of zmp-1::GFP expression shows that among the pairs of 1° inner and outer P6.pxxx cells that adopted different fates, 64/70, 33/38 and 48/52 had the proper orientation with vulF facing the normal position of the AC, respectively (Table 7)." | Paper_evidence | WBPaper00004481 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0007809 | PATO:0000460 | Paper_evidence | WBPaper00004481 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Genotype | syIs49 [zmp-1::GFP] | Paper_evidence | WBPaper00004481 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Reference | WBPaper00002125 | ||||||||
| WBPaper00004481 | |||||||||
| WBPaper00014894 | |||||||||
| Remark | Exons 3 and 6 are deleted and exons 4 and 5 are reaaranged. | Paper_evidence | WBPaper00024367 | ||||||
| Method | Allele |
