Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00241753

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00241753EvidencePaper_evidenceWBPaper00048558
NamePublic_names180
Other_names155Paper_evidenceWBPaper00000321
CE33587:p.Gln29Ter
Y18H1A.7a.1:c.85C>T
HGVSgCHROMOSOME_I:g.719551G>A
Sequence_detailsSMapS_parentSequenceY18H1A
Flanking_sequencescgccgatttatcgccagccggccagttatcagttcgatcggcgaccaggatacgttccga
Mapping_targetY18H1A
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00048558
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (22)
LaboratoryBC
StatusLive
AffectsGeneWBGene00004332
TranscriptY18H1A.7a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScY18H1A.7a.1:c.85C>T
HGVSpCE33587:p.Gln29Ter
cDNA_position345
CDS_position85
Protein_position29
Exon_number3/7
Codon_changeCag/Tag
Amino_acid_changeQ/*
GeneticsInterpolated_map_positionI-18.5548
DescriptionPhenotypeWBPhenotype:0000436Paper_evidenceWBPaper00032296
Curator_confirmedWBPerson712
RemarkSeven out of sixteen synapsed homolog pairs showed a ZHP-3 focus near the center of the chromosome, in contrast to four of five synapsed homolog pairs in wild-type animals with a ZHP-3 focus closer to one end.Paper_evidenceWBPaper00032296
Curator_confirmedWBPerson712
WBPhenotype:0000742Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkincreases meiotic recombination in gene clusters, reduces recombination on chromosome arms; distribution of crossovers in Rec-1 approximates physical map.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000143Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentUV sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 1Jm 10X-2/sec. Irradiated animals were protected from light. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000276Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentX-ray sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 470 r/min. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
ReferenceWBPaper00000565
WBPaper00016442
WBPaper00032296
WBPaper00048558
MethodSubstitution_allele