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WormBase Tree Display for Variation: WBVar00241620

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Name Class

WBVar00241620EvidencePaper_evidenceWBPaper00013472
NamePublic_namerm1
Other_nameC32E12.3.1:c.365-1G>A
HGVSgCHROMOSOME_I:g.5202802C>T
Sequence_detailsSMapS_parentSequenceC32E12
Flanking_sequencestaactgttctgaaaacaaatttgaatttcagaaatgcatttatcgatatgttgaatggaa
Mapping_targetC32E12
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000175
LaboratoryAM
StatusLive
AffectsGeneWBGene00016329
TranscriptC32E12.3.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScC32E12.3.1:c.365-1G>A
Intron_number3/9
GeneticsInterpolated_map_positionI-0.274236
DescriptionPhenotypeWBPhenotype:0000876Paper_evidenceWBPaper00032037
Curator_confirmedWBPerson712
RemarkAnimals are more resistant to stress in general, but also show less variation in stress response throughout the day as demonstrated by tap responsiveness after exposure to 350 mM NaCl. Diurnal variation of osmotic stress tolerence is present when higher concentrations of NaCl is used.Paper_evidenceWBPaper00032037
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were maintained at 16C under 12:12 h light:dark conditions. For testing, synchronized cultures of L1 larva were maintained without food for 3 days and entrained to LD conditions. Worms were fed with E.coli and kept at a final concentration of 15 worms/10ul at 25C. 50uM fluorodeoxyuridine (FuDR) was added when worms were L4.Paper_evidenceWBPaper00032037
Curator_confirmedWBPerson712
WBPhenotype:0001710Paper_evidenceWBPaper00032037
Curator_confirmedWBPerson712
RemarkAnimals show less variation in stress response throughout the day as demonstrated by tap responsiveness after exposure to 350 mM NaCl. Diurnal stress response is restored at higher concentrations of NaCl.Paper_evidenceWBPaper00032037
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were maintained at 16C under 12:12 h light:dark conditions. For testing, synchronized cultures of L1 larva were maintained without food for 3 days and entrained to LD conditions. Worms were fed with E.coli and kept at a final concentration of 15 worms/10ul at 25C. 50uM fluorodeoxyuridine (FuDR) was added when worms were L4.Paper_evidenceWBPaper00032037
Curator_confirmedWBPerson712
ReferenceWBPaper00032037
MethodSubstitution_allele