WormBase Tree Display for Variation: WBVar00241110

WBVar00241110 Evidence: Paper_evidence: WBPaper00002046
  Name: Public_name: q420
    Other_name: Y73C8B.4.1:c.725-1G>A
    HGVSg: CHROMOSOME_V:g.3189356G>A
  Sequence_details: SMap: S_parent: Sequence: Y73C8B
    Flanking_sequences: agagtctagacatgagaatttgttttttca gcgccaaatgcttcccaaacggtccgaaag
    Mapping_target: Y73C8B
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00002046
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00022546
    Laboratory: JK
    Status: Live
  Affects: Gene: WBGene00002246
    Transcript: Y73C8B.4.1 VEP_consequence: splice_acceptor_variant
        VEP_impact: HIGH
        HGVSc: Y73C8B.4.1:c.725-1G>A
        Intron_number: 3/4
    Interactor: WBInteraction000521259
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00002046
  Genetics: Interpolated_map_position: V -12.7104
  Description: Phenotype (15)
    Phenotype_not_observed: WBPhenotype:0000594 Paper_evidence: WBPaper00004662
        Curator_confirmed: WBPerson2987
        Remark: "We also observed the migration of P11/12 in a lag-2 mutant. LAG-2 is one of the four C_elegans homologs of the Delta protein, which is the ligand of Notch in Drosophila (Henderson et_al, 1994; Tax et_al, 1994). P11/12 migration is not clearly affected in this temperature-sensitive hypomorphic allele, although the bias in orientation may be reduced (Table 1C)." Paper_evidence: WBPaper00004662
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004409 PATO:0000460 Paper_evidence: WBPaper00004662
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001426 Paper_evidence: WBPaper00004883
        Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00004883
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: arIs37 Paper_evidence: WBPaper00004883
              Curator_confirmed: WBPerson712
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00038400
    WBPaper00006052
    WBPaper00004883
    WBPaper00032310
    WBPaper00001423
    WBPaper00004662
    WBPaper00039902
  Method: Substitution_allele